Elevated Levels of Type II Soluble Tumor Necrosis Factor Receptors in the Bronchoalveolar Lavage Fluids of Patients with Sarcoidosis

A Receptor for Tumor Necrosis Factor Defines an Unusual Family of Cellular and Viral Proteins

1990 • 977 citations

Molecular cloning and expression of the human 55 kd tumor necrosis factor receptor

1990 • 918 citations

Tumor necrosis factor soluble receptors circulate during experimental and clinical inflammation and can protect against excessive tumor necrosis factor alpha in vitro and in vivo.

1992 • 842 citations

Interstitial Lung Diseases of Unknown Cause

1984 • 696 citations

High Bronchoalveolar Levels of Tumor Necrosis Factor and Its Inhibitors, Interleukin-1, Interferon, and Elastase, in Patients with Adult Respiratory Distress Syndrome after Trauma, Shock, or Sepsis

1992 • 522 citations

Soluble forms of tumor necrosis factor receptors (TNF-Rs). The cDNA for the type I TNF-R, cloned using amino acid sequence data of its soluble form, encodes both the cell surface and a soluble form of the receptor.

1990 • 335 citations

Protection against endotoxic shock by a tumor necrosis factor receptor immunoadhesin.

1991 • 279 citations

Isolation and characterization of a tumor necrosis factor binding protein from urine

1989 • 249 citations

Current Concepts of the Pathogenesis of Sarcoidosis1,2

2015 • 239 citations

Tumor necrosis factor (TNF) receptor expression in T lymphocytes. Differential regulation of the type I TNF receptor during activation of resting and effector T cells.

1991 • 174 citations

Release of tumor necrosis factor by alveolar macrophages of patients with sarcoidosis.

1990 • 163 citations

Tumor necrosis factor production by human sarcoid alveolar macrophages.

1986 • 157 citations

Variation in serum levels of the soluble TNF receptors among healthy individuals.

1992 • 145 citations

Cellular and Molecular Aspects of Granulomatous Inflammation

1989 • 143 citations

Cloning of human tumor necrosis factor (TNF) receptor cDNA and expression of recombinant soluble TNF-binding protein.

1990 • 141 citations

Complementary DNA cloning of a receptor for tumor necrosis factor and demonstration of a shed form of the receptor.

1990 • 139 citations

Tumor necrosis factors-alpha and -beta bind to the same two types of tumor necrosis factor receptors and maximally activate the transcription factor NF-kappa B at low receptor occupancy and within minutes after receptor binding.

1990 • 132 citations

A tumor necrosis factor binding protein is present in human biological fluids

1988 • 122 citations

Alveolar macrophages from patients with beryllium disease and sarcoidosis express increased levels of mRNA for tumor necrosis factor-alpha and interleukin-6 but not interleukin-1 beta.

1994 • 103 citations

Enhanced expression of tumor necrosis factor receptor mRNA and protein in mononuclear cells isolated from rheumatoid arthritis synovial joints

1992 • 93 citations

The Relationship Between Alveolar Macrophage TNF, IL-1, and PGE2 Release, Alveolitis, and Disease Severity in Sarcoidosis

1993 • 71 citations

High concentrations of soluble tumor necrosis factor receptors in ascites

1992 • 59 citations

Tumor Necrosis Factor-α Plays a Central Role in Interleukin-2-Induced Pulmonary Vascular Leak and Lymphocyte Accumulation

1994 • 53 citations

An inhibitor of the toxicity of tumour necrosis factor in the serum of patients with sarcoidosis, tuberculosis and Crohn's disease

1990 • 53 citations

Lung Compartmentalization of Increased TNF Releasing Ability by Mononuclear Phagocytes in Pulmonary Sarcoidosis

1989 • 43 citations

Glucose, K⁺, and Albumin Concentrations in the Alveolar Milieu of Normal Humans and Pulmonary Sarcoidosis Patients

1991 • 41 citations

Vitronectin and Its Relationship to Other Extracellular Matrix Components in Bronchoalveolar Lavage Fluid in Sarcoidosis

1992 • 29 citations

Interleukin-1 Receptor Antagonist Expression in Sarcoidosis

1993 • 25 citations

Ultrastructural features of alveolitis in sarcoidosis.

1995 • 20 citations

Tumour necrosis factor receptor gene expression and shedding in human whole lung tissue and pulmonary epithelium

1996 • 20 citations

Interleukin-2-Induced Lymphocyte Infiltration of Multiple Organs Is Differentially Suppressed by Soluble Tumor Necrosis Factor Receptor

1994 • 15 citations