Temozolomide Plus Thalidomide in Patients With Advanced Melanoma: Results of a Dose-Finding Trial

Angiogenesis in cancer, vascular, rheumatoid and other disease

1995 • 7,717 citations

Thalidomide is an inhibitor of angiogenesis.

1994 • 2,460 citations

Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer.

2000 • 1,536 citations

Randomized Phase III Study of Temozolomide Versus Dacarbazine in the Treatment of Patients With Advanced Metastatic Malignant Melanoma

2000 • 1,252 citations

Thalidomide selectively inhibits tumor necrosis factor alpha production by stimulated human monocytes.

1991 • 1,209 citations

Multicenter Phase II Trial of Temozolomide in Patients With Anaplastic Astrocytoma or Anaplastic Oligoastrocytoma at First Relapse

1999 • 762 citations

Thalidomide Costimulates Primary Human T Lymphocytes, Preferentially Inducing Proliferation, Cytokine Production, and Cytotoxic Responses in the CD8+ Subset

1998 • 576 citations

Continuous low dose Thalidomide: a phase II study in advanced melanoma, renal cell, ovarian and breast cancer

2000 • 346 citations

Dacarbazine-based chemotherapy for metastatic melanoma: thirty-year experience overview.

2000 • 331 citations

Prospective Randomized Trial of the Treatment of Patients With Metastatic Melanoma Using Chemotherapy With Cisplatin, Dacarbazine, and Tamoxifen Alone or in Combination With Interleukin-2 and Interferon Alfa-2b

1999 • 318 citations

Temozolomide, a Novel Alkylating Agent with Activity in the Central Nervous System, May Improve the Treatment of Advanced Metastatic Melanoma

2000 • 315 citations

Thalidomide selectively modulates the density of cell surface molecules involved in the adhesion cascade

1996 • 295 citations

Cancer Research Campaign phase II trial of temozolomide in metastatic melanoma.

1995 • 290 citations

Phase I trial of temozolomide using an extended continuous oral schedule.

1998 • 284 citations

The immunosuppressive drug thalidomide induces T helper cell type 2 (Th2) and concomitantly inhibits Th1 cytokine production in mitogen- and antigen-stimulated human peripheral blood mononuclear cell cultures

1995 • 266 citations

Potentiation of cytotoxic cancer therapies by TNP‐470 alone and with other anti‐angiogenic agents

1994 • 241 citations

Current and future developments in the use of temozolomide for the treatment of brain tumours

2001 • 239 citations

Randomized trial of treatment with cisplatin and interleukin-2 either alone or in combination with interferon-?-2a in patients with metastatic melanoma

1999 • 71 citations

Current status of thalidomide in the treatment of cancer.

2001 • 33 citations