High-level ectopic HOXB4 expression confers a profound in vivo competitive growth advantage on human cord blood CD34+ cells, but impairs lymphomyeloid differentiation

Molecular Classification of Cancer: Class Discovery and Class Prediction by Gene Expression Monitoring

1999 • 11,586 citations

Gene Therapy of Human Severe Combined Immunodeficiency (SCID)-X1 Disease

2000 • 2,632 citations

Translating Stem and Progenitor Cell Biology to the Clinic: Barriers and Opportunities

2000 • 868 citations

The Biology and Clinical Uses of Blood Stem Cells

1997 • 729 citations

High-titer packaging cells producing recombinant retroviruses resistant to human serum

1995 • 672 citations

Transduction of Human CD34 ⁺ Cells That Mediate Long-Term Engraftment of NOD/SCID Mice by HIV Vectors

1999 • 648 citations

Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b

1998 • 643 citations

Overexpression of HOXB4 in hematopoietic cells causes the selective expansion of more primitive populations in vitro and in vivo.

1995 • 606 citations

Differential expression of homeobox genes in functionally distinct CD34+ subpopulations of human bone marrow cells.

1994 • 529 citations

The ‘cleavage’ activities of foot-and-mouth disease virus 2A site-directed mutants and naturally occurring ‘2A-like’ sequences

2001 • 507 citations

Selection of Drug-Resistant Bone Marrow Cells in Vivo After Retroviral Transfer of Human MDR 1

1992 • 500 citations

Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukaemia

1996 • 498 citations

Hematopoietic stem cell compartment: Acute and late effects of radiation therapy and chemotherapy

1995 • 472 citations

The t(7;11)(p15;p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP96 and class I homeoprotein HOXA9

1996 • 449 citations

Overexpression of HOXA10 in Murine Hematopoietic Cells Perturbs both Myeloid and Lymphoid Differentiation and Leads to Acute Myeloid Leukemia

1997 • 336 citations

Cooperative activation of Hoxa and Pbx1-related genes in murine myeloid leukaemias

1996 • 312 citations

Efficient retrovirus-mediated transfer of the multidrug resistance 1 gene into autologous human long-term repopulating hematopoietic stem cells

2000 • 280 citations

Enforced Expression of the GATA-2 Transcription Factor Blocks Normal Hematopoiesis

1999 • 239 citations

Novel retroviral vectors for efficient expression of the multidrug resistance (mdr-1) gene in early hematopoietic cells

1995 • 237 citations

HOXB4 overexpression mediates very rapid stem cell regeneration and competitive hematopoietic repopulation

2001 • 228 citations

Context Dependence of Different Modules for Posttranscriptional Enhancement of Gene Expression from Retroviral Vectors

2000 • 195 citations

Overexpression of HOXB3 in Hematopoietic Cells Causes Defective Lymphoid Development and Progressive Myeloproliferation

1997 • 187 citations

Efficient Retroviral-Mediated Gene Transfer to Human Cord Blood Stem Cells With In Vivo Repopulating Potential

1998 • 161 citations

Enhanced In Vivo Regenerative Potential of HOXB4-Transduced Hematopoietic Stem Cells With Regulation of Their Pool Size

1999 • 161 citations

Pluripotent hematopoietic stem cells contain high levels of mRNA for c-kit, GATA-2, p45 NF-E2, and c-myb and low levels or no mRNA for c-fms and the receptors for granulocyte colony-stimulating factor and interleukins 5 and 7.

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Serial transplantation of methotrexate-resistant bone marrow: protection of murine recipients from drug toxicity by progeny of transduced stem cells

1990 • 141 citations

Homeobox genes in leukemogenesis.

2000 • 133 citations

Conditional immortalization of mouse myelomonocytic, megakaryocytic and mast cell progenitors by the Hox-2.4 homeobox gene.

1993 • 119 citations

Overexpression of HOXA10 perturbs human lymphomyelopoiesis in vitro and in vivo

2001 • 118 citations

Highly Efficient Transduction of the Green Fluorescent Protein Gene in Human Umbilical Cord Blood Stem Cells Capable of Cobblestone Formation in Long-Term Cultures and Multilineage Engraftment of Immunodeficient Mice

1998 • 115 citations

Constitutive HOXA5 Expression Inhibits Erythropoiesis and Increases Myelopoiesis From Human Hematopoietic Progenitors

1999 • 103 citations

Meis1a suppresses differentiation by G-CSF and promotes proliferation by SCF: Potential mechanisms of cooperativity with Hoxa9 in myeloid leukemia

2001 • 96 citations

Retroviral vector-mediated expression of HoxB4 in hematopoietic cells using a novel coexpression strategy

2001 • 72 citations

High Efficiency Gene Transfer to Human Hematopoietic SCID-Repopulating Cells Under Serum-Free Conditions

1998 • 69 citations

Efficient transduction of human hematopoietic repopulating cells generating stable engraftment of transgene-expressing cells in NOD/SCID mice

2000 • 64 citations

Enforced expression of HOXB7 promotes hematopoietic stem cell proliferation and myeloid-restricted progenitor differentiation

1999 • 60 citations

Human alkyltransferase-transduced murine myeloid progenitors are enriched in vivo by BCNU treatment of transplanted mice.

1997 • 43 citations

Efficient retrovirus-mediated gene transfer to transplantable human bone marrow cells in the absence of fibronectin

2000 • 33 citations

Gene therapy of cancer : translational approaches from preclinical studies to clinical implementation

1999 • 31 citations

Enforced Expression of the GATA-2 Transcription Factor Blocks Normal Hematopoiesis

1999 • 24 citations

High Efficiency Gene Transfer to Human Hematopoietic SCID-Repopulating Cells Under Serum-Free Conditions

1998 • 8 citations