Tissue‐specific, Peptide‐binding Transplantation Antigens: Lessons from the Qa‐2 System

CELL-SURFACE ANCHORING OF PROTEINS VIA GLYCOSYL-PHOSPHATIDYLINOSITOL STRUCTURES

1988 • 1,284 citations

Structural and Functional Roles of Glycosyl-Phosphatidylinositol in Membranes

1988 • 963 citations

The Ly-49 and NKR-P1 Gene Families Encoding Lectin-Like Receptors on Natural Killer Cells: The NK Gene Complex

1993 • 465 citations

Caveolin moves from caveolae to the Golgi apparatus in response to cholesterol oxidation.

1994 • 425 citations

The Immunobiology of T Cells with Invariant gammadelta Antigen Receptors

1991 • 343 citations

Organization and evolution of the class I gene family in the major histocompatibility complex of the C57BL/10 mouse

1984 • 323 citations

A pseudogene homologous to mouse transplantation antigens: Transplantation antigens are encoded by eight exons that correlate with protein domains

1981 • 320 citations

Phosphatidylinositol membrane anchors and T-cell activation

1991 • 263 citations

Antigen Presentation by Major Histocompatibility Complex Class I-B Molecules

1994 • 248 citations

Plasmalemmal caveolae and GPI-anchored membrane proteins

1993 • 186 citations

Murine CD8+ T cells that specifically delete autologous CD4+ T cells expressing Vβ8 TCR: a role of the Qa-1 molecule

1995 • 175 citations

A glycophospholipid anchor is required for Qa-2-mediated T cell activation

1989 • 169 citations

TheTla region of the mouse: Identification of a new serologically defined locus,Qa-2

1976 • 168 citations

Molecules Related to Class-I Major Histocompatibility Complex Antigens

1990 • 146 citations

Maternally Transmitted Antigen of Mice: A Model Transplantation Antigen

1991 • 141 citations

Genetic mapping in the major histocompatibility complex by restriction enzyme site polymorphisms: most mouse class I genes map to the Tla complex.

1983 • 136 citations

Differences between the lateral organization of conventional and inositol phospholipid-anchored membrane proteins. A further definition of micrometer scale membrane domains.

1991 • 126 citations

A single gene encodes soluble and membrane-bound forms of the major histocompatibility Qa-2 antigen: Anchoring of the product by a phospholipid tail

1987 • 118 citations

TAP associates with a unique class I conformation, whereas calnexin associates with multiple class I forms in mouse and man.

1995 • 116 citations

The interaction of monoclonal antibodies with MHC class I antigens on mouse spleen cells. I. Analysis of the mechanism of binding.

1984 • 115 citations

Glycosyl-phosphatidylinositol-anchored membrane proteins.

1992 • 114 citations

Duplicated gene pairs and alleles of class I genes in the Qa2 region of the murine major histocompatibility complex: a comparison.

1985 • 107 citations

A nonpolymorphic major histocompatibility complex class Ib molecule binds a large array of diverse self-peptides.

1994 • 99 citations

Correction of the class H defect in glycosylphosphatidylinositol anchor biosynthesis in Ltk- cells by a human cDNA clone.

1993 • 95 citations

Qa-2 molecules are peptide receptors of higher stringency than ordinary class I molecules

1993 • 94 citations

Structure and expression of genes encoding murine Qa-2 class I antigens.

1985 • 86 citations

Expression of classical and non-classical MHC class I antigens in murine hair follicles

2006 • 84 citations

Negative and positive selection of antigen-specific cytotoxic T lymphocytes affected by the α3 domain of MHC I molecules

1991 • 81 citations

Identification of a new CML target antigen controlled by a gene associated with theQa-2 locus

1978 • 76 citations

Conversion of a PI-Anchored Protein to an Integral Membrane Protein by a Single Amino Acid Mutation

1988 • 70 citations

Serologic cross-reactivity between Class I MHC molecules and an H-2-linked differentiation antigen as detected by monoclonal antibodies.

1984 • 68 citations

Killing of skin-derived tumor cells by mouse dendritic epidermal T-cells.

1993 • 66 citations

Tissue-specific expression of cell-surface Qa-2 antigen from a transfected Q7b gene of C57BL/10 mice.

1987 • 66 citations

Profiles of Cytokine mRNA Expressed by Dendritic Epidermal T Cells in Mice

1993 • 65 citations

Qa gene expression: biosynthesis and secretion of Qa-2 molecules in activated T cells.

1986 • 64 citations

Antigen presentation by non-classical class I molecules

1994 • 64 citations

Extensive deletions in the Q region of the mouse major histocompatibility complex

1986 • 62 citations

Molecular mapping of signals in the Qa-2 antigen required for attachment of the phosphatidylinositol membrane anchor.

1988 • 60 citations

Aglycosylated and phosphatidylinositol-anchored MHC class I molecules are associated with calnexin. Evidence implicating the class I-connecting peptide segment in calnexin association.

1995 • 57 citations

Further biochemical data on Qa-2

1981 • 56 citations

Qa antigen expression on functional lymphoid, myeloid, and stem cells in adult mice.

1980 • 54 citations

Qa-2 expression in the adult murine thymus. A unique marker for a mature thymic subset.

1989 • 53 citations

Identification of the Ped Gene at the Molecular Level: The Q9 MHC Class I Transgene Converts the Ped Slow to the Ped Fast Phenotype1

1994 • 50 citations

Two different biosynthetic pathways for the secretion of Qa region-associated class I antigens by mouse lymphocytes.

1987 • 48 citations

Anti-Qa-2-induced T cell activation. The parameters of activation, the definition of mitogenic and nonmitogenic antibodies, and the differential effects on CD4+ vs CD8+ T cells.

1989 • 46 citations

The QA2 subregion controls the expression of two antigens recognized by H-2- unrestricted cytotoxic T cells

1982 • 45 citations

Sequence of the mouse Q4 class I gene and characterization of the gene product

1988 • 44 citations

Activated T cells transcribe an alternatively spliced mRNA encoding a soluble form of Qa-2 antigen.

1990 • 43 citations

Expression and T cell recognition of hybrid antigens with amino-terminal domains encoded by Qa-2 region of major histocompatibility complex and carboxyl termini of transplantation antigens.

1985 • 41 citations

Characterization of a Q subregion gene in the murine major histocompatibility complex.

1985 • 41 citations

Expression of secreted and glycosylphosphatidylinositol-bound Qa-2 molecules is dependent on functional TAP-2 peptide transporter.

1994 • 39 citations

Qa-region class I gene expression: identification of a second class I gene, Q9, encoding a Qa-2 polypeptide.

1988 • 35 citations

Epitope clusters of Qa-2 antigens defined by a panel of new monoclonal antibodies.

1989 • 35 citations

Alternative splicing of class Ib majorhistocompatibility complex transcripts in vivo leads to the expression ofsoluble Qa-2 molecules in murine blood.

1994 • 34 citations

Analysis of T cell receptors specific for recognition of class IB antigens.

1993 • 33 citations

Qa-2 does not display structural genetic polymorphism detectable on isoelectric-focusing gels

1982 • 31 citations

Interaction of alpha 1 with alpha 2 region in class I MHC proteins contributes determinants recognized by antibodies and cytotoxic T cells.

1985 • 30 citations

Expression of hybrid class I genes of the major histocompatibility complex in mouse L cells.

1985 • 27 citations

Peptide antigen presentation by non-classical MHC class I molecules

1993 • 27 citations

Increased Qa-m7 antigen expression is characteristic of primitive hemopoietic progenitors in regenerating marrow.

1987 • 25 citations

Qb-1, a new class I polypeptide encoded by the Qa region of the mouse H-2 complex

1985 • 25 citations

Qa ANTIGENS AND THEIR DIFFERENTIAL DISTRIBUTION ON LYMPHOID, MYELOID AND STEM CELLS

1984 • 24 citations

Monoclonal antibody reveals H-2-linked quantitative and qualitative variation in the expression of a Qa-2 region determinant

1983 • 22 citations

Qa-2 antigen encoded by Q7b is biochemically indistinguishable from Qa-2 expressed on the surface of C57BL/10 mouse spleen cells.

1988 • 19 citations

The Q7 alpha 3 domain alters T cell recognition of class I antigens.

1991 • 19 citations

The alpha 3 domain of the Qa-2 molecule is defective for CD8 binding and cytotoxic T lymphocyte activation.

1993 • 19 citations

Physical and molecular genetic analysis of Qa-2 antigen expression: Multiple factors controlling cell surface levels

1991 • 17 citations

Genetic polymorphisms ofQ region genes from wild-derived mice: Implications forQ region evolution

1990 • 16 citations

Further characterization of the membrane anchor found on the tissue-specific class I molecule Qa2.

1988 • 16 citations

Expression and function of Qa-2 major histocompatibility complex class I molecules in transgenic mice

1991 • 15 citations

Separation of thymic education from antigen presenting functions of major histocompatibility complex class I molecules.

1994 • 15 citations

Qa alloantigen expression on functional T lymphocytes from spleen and thymus

1986 • 15 citations

Recognition by cytotoxic T lymphocytes of Qa-2 antigens. Sensitivity of Qa-2 molecules to phosphatidylinositol-specific phospholipase C.

1988 • 15 citations

Molecular signals for phosphatidylinositol modification of the Qa-2 antigen.

1990 • 10 citations

The H-2 dm1 mutation and Qa antigens

1983 • 9 citations

Variable expression of Qa‐m7, Qa‐m8, and Qa‐m9 antigenic determinants on primitive hemopoietic precursor cells

1985 • 9 citations

An H-2Ld hybrid molecule with a Qa-2 alpha-3 domain and phosphatidyl-inositol anchor is not recognized by H-2Ld-specific cytotoxic T lymphocytes.

1989 • 9 citations

NH2-terminal amino acid sequence analysis of Qa-2 alloantigens

1989 • 8 citations

MHC gene Q8/9 d of the BALB/cJ mouse strain cannot encode a Qa-2,3 class I antigen

1991 • 8 citations

Quantitative differences in cell surface expression of class I MHC antigens on murine epidermal Langerhans cells.

1994 • 8 citations

Differential expression of Q4 proteins (Qb-1) in fibroblasts and lymphocytes.

1991 • 7 citations

Expression and regulation of Q8 b in a transfected cell line

1991 • 6 citations

Biosynthesis of glycophospholipid bound and secreted murine class I Qa-2 polypeptides

1991 • 5 citations

Antigenic Heterogeneity of Qa‐2 Antigens in C57BL/6

1993 • 1 citations