Immunological aspects of aging: Early changes in thymic activity

A Direct Measurement of the Radiation Sensitivity of Normal Mouse Bone Marrow Cells¹

2010 • 4,125 citations

A Direct Measurement of the Radiation Sensitivity of Normal Mouse Bone Marrow Cells

1961 • 3,579 citations

Dietary Restriction in Mice Beginning at 1 Year of Age: Effect on Life-Span and Spontaneous Cancer Incidence

1982 • 757 citations

Science and Art in Preparing Tissues Embedded in Plastic for Light Microscopy, with Special Reference to Glycol Methacrylate, Glass Knives and Simple Stains

1976 • 572 citations

THYMUS-DEPENDENT AREAS IN THE LYMPHOID ORGANS OF NEONATALLY THYMECTOMIZED MICE

1966 • 537 citations

Mechanism of removal of senescent cells by human macrophages in situ.

1975 • 345 citations

Changes in Blood Hormone Levels during the Immune Response

1975 • 342 citations

Intrathymic and Extrathymic T Cell Maturation

1978 • 327 citations

Influence of Brain and Behavior on the Immune System

1976 • 291 citations

ISOLATION, BIOCHEMICAL CHARACTERISTICS, AND BIOLOGICAL ACTIVITY OF A CIRCULATING THYMIC HORMONE IN THE MOUSE AND IN THE HUMAN

1975 • 288 citations

The chemistry and biology of thymosin. I. Isolation, characterization, and biological activities of thymosin alpha1 and polypeptide beta1 from calf thymus.

1979 • 268 citations

Thymosin Stimulates Secretion of Luteinizing Hormone-Releasing Factor

1981 • 258 citations

TISSUE GRAFTING AND RADIATION

1967 • 225 citations

Is terminal deoxynucleotidyl transferase a somatic mutagen in lymphocytes?

1974 • 205 citations

Immunological studies of aging. IV. The contribution of thymic involution to the immune deficiencies of aging mice and reversal with thymopoietin32-36.

1978 • 202 citations

The chemistry and biology of thymosin. II. Amino acid sequence analysis of thymosin alpha1 and polypeptide beta1.

1979 • 191 citations

Senescent cell antigen is immunologically related to band 3.

1983 • 185 citations

Thymic Involution: Effect on T Cell Differentiation

1975 • 183 citations

THE WEIGHT OF THE THYMUS GLAND IN HEALTH AND IN DISEASE

1932 • 181 citations

THE THYMUS AND LYMPH-NODES IN RADIATION CHIMÆRAS

1963 • 181 citations

Effect of Thymectomy in Adult Mice on Immunological Responsiveness

1965 • 179 citations

SCREENING FOR BREAST CANCER

1976 • 169 citations

Influence of controlled dietary restriction on immunologic function and aging.

1979 • 154 citations

Lymphocytes, Hormones and Ageing

1972 • 149 citations

Functional Analysis of Murine and Human B Lymphocyte Subsets

1975 • 140 citations

Delayed Effect of Thymectomy in Adult Life on Immunological Competence

1965 • 137 citations

Studies on thymus products. IV. Absence of serum 'thymic activity' in adult NZB and (NZB x NZW) F1 mice.

1973 • 134 citations

Immunologic theory of aging: current status.

1974 • 129 citations

Theta-Sensitive Cell and Erythropoiesis: Identification of a Defect in W / W ^v Anemic Mice

1977 • 129 citations

Modification of age-related immune decline in mice dietarily restricted from or after midadulthood.

1982 • 128 citations

Chemical characterization of thymosin beta 4.

1982 • 126 citations

Decay of Immunological Responsiveness after Thymectomy in Adult Life

1965 • 123 citations

THE INFLOW OF BONE MARROW CELLS TO THE THYMUS: STUDIES WITH PART‐BODY IRRADIATED MICE INJECTED WITH CHROMOSOME‐MARKED BONE MARROW AND SUBJECTED TO ANTIGENIC STIMULATION

1966 • 120 citations

Age-Related Decrease in Mouse T Cell Progenitors

1977 • 115 citations

Immunobiology of aging: Evaluation of current status

1976 • 115 citations

Decline in Phytohemagglutinin Responsiveness of Spleen Cells from Aging Mice

1973 • 109 citations

Relationship between Thymus and Hypophysis

1967 • 109 citations

Quantitative effects of nutritional protein and calorie deficiency upon immune responses to tumors in mice.

1973 • 97 citations

Thymopoietin Enhances the Allogeneic Response and Cyclic GMP Levels of Mouse Peripheral, Thymus-Derived Lymphocytes

1978 • 94 citations

Electron microscopic studies of the epithelial reticular cells of the mouse thymus

1963 • 92 citations

Autoimmune phenomena and renal disease in mice. Role of thymectomy, aging, and involution of immunologic capacity.

1970 • 87 citations

Studies on thymus products. 3. Epithelial origin of the serum thymic factor.

1974 • 82 citations

Haemopoietic stem cells and progenitors of functional T-lymphocytes in the bone marrow of 'nude' mice.

1973 • 82 citations

Relationship between Aging and the Immune System

2015 • 78 citations

An overview of immune aging

1979 • 76 citations

Immunological Studies of Nude Mice

1974 • 75 citations

Restoration of impaired immune functions in aging animals

1976 • 75 citations

Reduced humoral immune activity in long-lived old mice: an approach to elucidating its mechanisms.

1976 • 69 citations

Age-related changes in the immune system of mice of eight medium and long-lived strains and hybrids. I. Organ, cellular, and activity changes

1979 • 62 citations

Thymus Specificity in Lethally Irradiated Mice Treated with Rat Bone Marrow

1957 • 59 citations

Thymus-dependent recersibility of physiological and isoproterenol evoked age-related parameters in athymic (nude) and old normal mice

1978 • 53 citations

Antigenicity, storage, and aging: physiologic autoantibodies to cell membrane and serum proteins and the senescent cell antigen

1982 • 50 citations

Influence of dietary protein restriction on immune competence. I. Effect on the capacity of cells from various lymphoid organs to induce graft-vs.-host reactions.

1975 • 47 citations

Adult thymectomy promotes the manifestation of autoreactive lymphocytes

1977 • 45 citations

Age-related changes, including synergy and suppression, in the mixed lymphocyte reaction in long-lived mice

1975 • 44 citations

Immunological aspects of aging

1981 • 43 citations

Thymosin and the immunopathology of aging.

1974 • 39 citations

Multiple labelling technique used for kinetic studies of activated human B lymphocytes

1975 • 38 citations

Failure of Spleen Cells from Thymectomized Mice to Induce Graft vs. Host Reactions.

1962 • 38 citations

The growth and involution of lymphatic tissue and its interrelationships to aging and to the growth of the adrenal glands and sex organs in CBA mice

1960 • 38 citations

Effect of age on T cell differentiation.

1978 • 35 citations

Tolerance, autoimmunity, and aging

1972 • 31 citations

Susceptibility to Involution of the Thymus-dependent Lymphoid System and Autoimmunity

1971 • 31 citations

The Thymus: Clock for Immunologic Aging?

1979 • 30 citations

Hypopituitary dwarf and athymic nude mice and the study of the relationships among thymus, hormones, and aging.

1978 • 27 citations

Lymphocyte populations of AKR-J mice. I. Effect of aging on migration patterns, response to PHA and expression of theta antigen.

1973 • 26 citations

The restoration of the T-lymphoid system of nude mice: Lower efficiency of nonlymphoid, epithelial thymus grafts

1977 • 26 citations

Thymosin: Cyclic nucleotides and T cell differentiation

1979 • 26 citations

Strain-, Age-, and Tumor-Dependent Distribution of Terminal Deoxynucleotidyl Transferase in Thymocytes of Mice

1976 • 25 citations

Age-associated involution of cellular immune function. I. Accelerated decline of mitogen reactivity of spleen cells in adult thymectomized mice.

1976 • 21 citations

DECREASED LONGEVITY OF MICE FOLLOWING THYMECTOMY IN ADULT LIFE

1971 • 20 citations

Early decline of thymic effect on T cell differentiation

1978 • 20 citations

Involution of the Thymus Dependent Lymphoid System

1973 • 19 citations

IgE antibody formation and aging. I. Age-related changes in IgE antibody formation and avidity for the DNP-determinant in mice.

1979 • 18 citations

Appearance of a terminal differentiation antigen on senescent and damaged cells and its implications for physiologic autoantibodies.

1983 • 17 citations

Cells, Signals, and Receptors: The Role of Physiological Autoantibodies in Maintaining Homeostasis

1980 • 16 citations

Decreased longevity of mice following thymectomy in adult life.

1971 • 15 citations

Augmentation of marrow growth by thymocytes separated by discontinuous albumin density-gradient centrifugation.

1975 • 12 citations

Effect of thymocyte-stimulating factor-containing supernatants on the surface antigens of murine thymocytes

1979 • 12 citations

IgE Antibody Formation and Aging

1979 • 11 citations

Identification of T cell subpopulations binding phytohemagglutinin: functional characteristics

1978 • 9 citations

Restoration of the T lymphoid system of nude mice: different regeneration of neonatal and adult thymuses

1977 • 6 citations

Neonatal thymus grafts. II. Cellular events.

1979 • 5 citations

Antigenic changes associated with cellular aging.

1983 • 3 citations