Immunopharmacologic Modulation of Experimental Allergic Encephalomyelitis: Low‐Dose Cyclosporin‐A Treatment Causes Disease Relapse and Increased Systemic T and B Cell‐Mediated Myelin‐Directed Autoimmunity

Large Scale Preparation of Myelin Basic Protein from Central Nervous Tissue of Several Mammalian Species

1972 • 949 citations

The rapid isolation of clonable antigen‐specific T lymphocyte lines capable of mediating autoimmune encephalomyelitis

1981 • 917 citations

Surface expression of alpha 4 integrin by CD4 T cells is required for their entry into brain parenchyma.

1993 • 837 citations

Treatment of multiple sclerosis with gamma interferon

1987 • 739 citations

Augmentation of demyelination in rat acute allergic encephalomyelitis by circulating mouse monoclonal antibodies directed against a myelin/oligodendrocyte glycoprotein.

1988 • 721 citations

Reverse ELISPOT assay for clonal analysis of cytokine production I. Enumeration of gamma-interferon-secreting cells

1988 • 496 citations

Autoreactive T lymphocytes in multiple sclerosis determined by antigen-induced secretion of interferon-gamma.

1990 • 363 citations

Experimental Allergic Encephalomyelitis. A Useful Model for Multiple Sclerosis

1984 • 340 citations

Intrathecal application of interferon gamma. Progressive appearance of MHC antigens within the rat nervous system.

1990 • 240 citations

The Purification and Characterization of Rat Gamma Interferon by Use of Two Monoclonal Antibodies

1986 • 204 citations

Involvement of distinct murine T-cell receptors in the autoimmune encephalitogenic response to nested epitopes of myelin basic protein.

1988 • 172 citations

Experimental allergic neuritis in the Lewis rat: Characterization of the activity of peripheral myelin and its major basic protein,P2

1980 • 172 citations

Frequency of T cells specific for myelin basic protein and myelin proteolipid protein in blood and cerebrospinal fluid in multiple sclerosis

1992 • 163 citations

Direct injection of cytokines into the spinal cord causes autoimmune encephalomyelitis-like inflammation

1990 • 163 citations

Specificity of T lymphocyte lines for peptides of myelin basic protein.

1985 • 125 citations

Increased numbers of T cells recognizing multiple myelin basic protein epitopes in multiple sclerosis

1992 • 117 citations

T cell immunity and interferon-γ secretion during experimental allergic encephalomyelitis in Lewis rats

1991 • 107 citations

Immunoglobulin-deficient rats fail to develop experimental allergic encephalomyelitis

1983 • 99 citations

T cell determinants of myelin basic protein include a unique encephalitogenic I-E-restricted epitope for Lewis rats.

1989 • 98 citations

Suppression of experimental allergic encephalomyelitis by mitoxantrone

1985 • 96 citations

Low-dose cyclosporin A induces relapsing remitting experimental allergic encephalomyelitis in the Lewis rat

1988 • 95 citations

A filter immuno-plaque assay for the detection of antibody-secreting cells in vitro

1985 • 93 citations

Synergy between encephalitogenic T cells and myelin basic protein-specific antibodies in the induction of experimental autoimmune encephalomyelitis

1992 • 86 citations

Suppression of acute and relapsing experimental allergic encephalomyelitis with mitoxantrone

1987 • 77 citations

The major histocompatibility complex influences myelin basic protein 63‐88‐induced T cell cytokine profile and experimental autoimmune encephalomyelitis

1993 • 71 citations

Chronic experimental autoimmune encephalomyelitis induced by the 89‐101 myelin basic protein peptide in B10RIII (H2^r) mice

1991 • 63 citations

Suppression of demyelination by mitoxantrone

1991 • 61 citations

Regional suppression, therapy after onset and prevention of relapses in experimental allergic encephalomyelitis by mitoxantrone

1986 • 56 citations

The neuropathology of chronic relapsing experimental allergic encephalomyelitis induced in the Lewis rat by inoculation with whole spinal cord and treatment with cyclosporin A

1990 • 46 citations

Cyclosporine-Induced Autoimmunity and Immune Hyperreactivity

1991 • 42 citations

Experimental allergic encephalomyelitis in the Lewis rat

1987 • 37 citations

Cells producing antibodies specific for myelin basic protein region 70–89 are predominant in cerebrospinal fluid from patients with multiple sclerosis

1991 • 35 citations

Distribution of plasma cells secreting antibodies against nervous tissue antigens during experimental allergic encephalomyelitis enumerated by a nitrocellulose immunospot assay

1989 • 30 citations

Control of immune-mediated disease of the central nervous system requires the use of a neuroactive agent: elucidation by the action of mitoxantrone

1992 • 25 citations

Natural history and treatment of multiple sclerosis.

1992 • 23 citations

Sulfasalizine aggravates experimental autoimmune encephalomyelitis and causes an increase in the number of autoreactive T cells

1991 • 16 citations

Susceptibility to experimental allergic encephalomyelitis in animal models of autoimmunity.

1992 • 15 citations