The cytolytic and regulatory role of natural killer cells in human neoplasia

Selective rejection of H–2-deficient lymphoma variants suggests alternative immune defence strategy

1986 • 2,102 citations

„Natural”︁ killer cells in the mouse. I. Cytotoxic cells with specificity for mouse Moloney leukemia cells. Specificity and distribution according to genotype

1975 • 1,743 citations

The Concept of Immunological Surveillance

2015 • 1,586 citations

Natural cytotoxic reactivity of mouse lymphoid cells against syngeneic and allogeneic tumors. I. Distribution of reactivity and specificity

1975 • 1,308 citations

Characteristics of human large granular lymphocytes and relationship to natural killer and K cells

1981 • 1,008 citations

Subpopulations of human natural killer cells defined by expression of the Leu-7 (HNK-1) and Leu-11 (NK-15) antigens.

1983 • 852 citations

T Cell Subsets and the Recognition of MHC Class

1983 • 702 citations

Dissection of the lymphokine-activated killer phenomenon. Relative contribution of peripheral blood natural killer cells and T lymphocytes to cytolysis.

1986 • 698 citations

Lymphocyte-Mediated Cytotoxicity And Blocking Serum Activity To Tumor Antigens

1974 • 651 citations

NK Cells and Other Natural Effector Cells

1982 • 624 citations

Natural Cytotoxic Reactivity of Human Lymphocytes Against a Myeloid Cell Line: Characterization of Effector Cells

1977 • 493 citations

Human natural killer cells analyzed by B73.1, a monoclonal antibody blocking Fc receptor functions. I. Characterization of the lymphocyte subset reactive with B73.1.

1983 • 414 citations

Capacity of human large granular lymphocytes (LGL) to produce multiple lymphokines: interleukin 2, interferon, and colony stimulating factor.

1983 • 294 citations

Direct evidence for the role of LGL in the inhibition of experimental tumor metastases.

1985 • 279 citations

Morphological and Functional Characterization of Isolated Effector Cells Responsible for Human Natural Killer Activity to Fetal Fibroblasts and to Cultured Cell Line Targets

1979 • 273 citations

Cell-Mediated Immunity to Tumor Cells

1974 • 268 citations

Leu-11+ lymphocytes with natural killer (NK) activity are precursors of recombinant interleukin 2 (rIL 2)-induced activated killer (AK) cells.

1985 • 263 citations

Effects of a cloned cell line with NK activity on bone marrow transplants, tumour development and metastasis in vivo

1982 • 228 citations

Purification and properties of cytoplasmic granules from cytotoxic rat LGL tumors.

1984 • 219 citations

Suppressive effect of human natural killer cells on pokeweed mitogen-induced B cell differentiation.

1983 • 178 citations

Human natural killer cells isolated from peripheral blood do not rearrange T cell antigen receptor beta chain genes.

1986 • 178 citations

Suppressor cell function of human granular lymphocytes identified by the HNK-1 (Leu 7) monoclonal antibody.

1983 • 175 citations

YAC-1 MHC class I variants reveal an association between decreased NK sensitivity and increased H-2 expression after interferon treatment or in vivo passage.

1985 • 171 citations

Studies on the mechanism of natural killer (NK) cell-mediated cytotoxicity (CMC). I. Release of cytotoxic factors specific for NK-sensitive target cells (NKCF) during co-culture of NK effector cells with NK target cells.

1982 • 153 citations

NK and T cell subsets regulate antibody production by human in vivo antigen-induced lymphoblastoid B cells.

1984 • 145 citations

Current concepts in human immunology and cancer immunomodulation

1981 • 141 citations

Cloned human cytotoxic T lymphocyte (CTL) lines reactive with autologous melanoma cells. I. In vitro generation, isolation, and analysis to phenotype and specificity.

1984 • 133 citations

Depression of natural killer cytotoxic activity in lymphocytes infiltrating human pulmonary tumors.

1985 • 129 citations

Cytotoxic T‐Lymphocytes How Do They Function?

1983 • 124 citations

Immunohistologic Characterization of Major Histocompatibility Antigens and Inflammatory Cellular Infiltrate in Human Breast Cancer<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1983 • 119 citations

Human tumour—lymphocyte interaction in vitro. V. Comparison of the reactivity of tumour‐infiltrating, blood and lymph‐node lymphocytes with autologous tumour cells

1977 • 119 citations

Natural cytotoxicity in man: activity of lymph node and tumor‐infiltrating lymphocytes

1977 • 110 citations

Expression of major histocompatibility antigens and leucocyte infiltration in benign and malignant human breast disease

1984 • 109 citations

Clonal analysis of cytotoxic T‐lymphocyte response to autologous human metastatic melanoma

1985 • 107 citations

Lymphocyte cytotoxicity against autologous tumour biopsy cells in humans

1977 • 104 citations

Natural killer activity of lymphoid cells isolated from human ascitic ovarian tumors

1980 • 102 citations

Role of alloantigens in natural killing. Allogeneic but not autologous tumor biopsy cells are sensitive for interferon-induced cytotoxicity of human blood lymphcoytes.

1980 • 100 citations

Polarization of NK cell cytoskeleton upon conjugation with sensitive target cells.

1983 • 97 citations

Intrapleural administration of OK432 in cancer patients: Activation of nk cells and reduction of suppressor cells

1983 • 95 citations

Studies on the mechanism of natural killer cytotoxicity. II. coculture of human PBL with NK-sensitive or resistant cell lines stimulates release of natural killer cytotoxic factors (NKCF) selectively cytotoxic to NK-sensitive target cells.

1983 • 86 citations

Cultures of purified human natural killer cells: Growth in the presence of interleukin 2

1982 • 83 citations

Specificity of auto‐tumor cytotoxicity exerted by fresh, activated and propagated human t lymphocytes

1982 • 82 citations

Immunohistochemical study with monoclonal antibodies on immune response in human lung cancers.

1983 • 81 citations

Identification of human natural killer soluble cytotoxic factors (NKCF) derived from NK-enriched lymphocyte populations: specificity of generation and killing.

1983 • 80 citations

Generation of suppressor cells for natural killer activity in cancer patients after surgery.

1982 • 79 citations

Mechanism of cell-mediated cytotoxicity at the single cell level. IV. Natural killing and antibody-dependent cellular cytotoxicity can be mediated by the same human effector cell as determined by the two-target conjugate assay.

1982 • 78 citations

Lysis of fresh human tumor cells by autologous large granular lymphocytes from peripheral blood and pleural effusions

1983 • 75 citations

Lysis of Fresh Human Tumor Cells by Autologous Peripheral Blood Lymphocytes and Pleural Effusion Lymphocytes Activated by OK432<xref ref-type="fn" rid="FN2">2</xref>

1983 • 74 citations

Extravascular natural cytotoxicity in man: Anti‐K562 activity of lymph‐node and tumour‐infiltrating lymphocytes

1981 • 72 citations

Specific and non-specific lymphocyte cytotoxicity in colon carcinoma

1981 • 70 citations

Human lymphokine-activated killer cells (LAK cells) as a potential immunotherapeutic modality

1986 • 68 citations

Lymphocytes infiltrating human breast cancers lack K-cell activity and show low levels of NK-cell activity

1981 • 67 citations

Characterisation of breast cancer infiltrates using monoclonal antibodies to human leucocyte antigens

1984 • 66 citations

Intrapleural administration of OK432 in cancer patients: Augmentation of autologous tumor killing activity of tumor-associated large granular lymphocytes

1984 • 66 citations

A cloned human T cell line cytotoxic for autologous and allogeneic B lymphoma cells.

1984 • 57 citations

Proceedings of the 9th International Cancer Congress

1967 • 56 citations

In vitro migration of human large granular lymphocytes.

1985 • 52 citations

Immunoperoxidase localization of large granular lymphocytes in normal tissues and lesions of athymic nude rats.

1983 • 51 citations

Restricted autologous lymphocytotoxicity in lung neoplasia

1978 • 49 citations

Suppressor cells for natural killer activity in carcinomatous pleural effusions of cancer patients

1981 • 49 citations

Is the NK lytic process involved in the mechanism of NK suppression of antibody-producing cells?

1985 • 47 citations

Natural and activated cytotoxic lymphocytes which act on autologous and allogeneic tumor cells

1981 • 45 citations

Analysis of T cell receptors in highly purified rat and human large granular lymphocytes (LGL): lack of functional 1.3 kb beta-chain mRNA.

1986 • 44 citations

Natural killer cells in carcinomatous pleural effusions

1981 • 44 citations

Human Tumor-Lymphocyte Interaction In Vitro. VI. Specificity of Primary and Secondary Autologous Lymphocyte-Mediated Cytotoxicity<xref ref-type="fn" rid="FN2">2</xref>

1979 • 44 citations

Defective Natural Killer Activity Within Human Ovarian Tumors: Low Numbers of Morphologically Defined Effectors Present in Situ<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1983 • 41 citations

Inhibition of natural killer activity by tumor-associated lymphoid cells from ascites ovarian carcinomas.

1981 • 40 citations

Human natural killer cells can inhibit clonogenic growth of fresh leukemic cells

1983 • 40 citations

Possible Role of Natural Killer Cells and Other Effector Cells in Immune Surveillance Against Cancer

1984 • 39 citations

Mechanisms of Cell-Mediated Cytotoxicity II

1985 • 38 citations

Specific T-cell-mediated killing of autologous lung tumour cells

1980 • 36 citations

Human epidermal cells and squamous carcinoma cells synthesize a cytokine that augments natural killer cell activity.

1985 • 36 citations

Lysis of lymphoma cells by autologous and allogeneic natural killer cells

1985 • 28 citations

Natural Killer Cell Activity and Autologous Tumor Killing Activity in Cancer Patients: Overlapping Involvement of Effector Cells as Determined in Two-Target Conjugate Cytotoxicity Assay<xref ref-type="fn" rid="FN2">2</xref>

1984 • 28 citations

Natural Cytotoxicity of Human Blood Lymphocytes and Monocytes and Their Cytotoxic Factors: Effect of Interferon on Target Cell Susceptibility2

1985 • 28 citations

Interferon Effect on Cytotoxicity of Peripheral Blood and Tumor-Associated Lymphocytes Against Human Ovarian Carcinoma Cells<xref ref-type="fn" rid="fn2">2</xref><xref ref-type="fn" rid="fn3">3</xref>

1982 • 26 citations

Possible Role of Natural Killer Cells and Other Effector Cells in Immune Surveillance Against Cancer.

1984 • 25 citations

Natural cytotoxicity of human blood monocytes and natural killer cells and their cytotoxic factors: Discriminating effects of actinomycin D

1985 • 23 citations

Lysis of Fresh Human Tumor Cells by Autologous Large Granular Lymphocytes and T-Lymphocytes: Two Distinct Killing Activities Induced by Coculture With Autologous Tumor<xref ref-type="fn" rid="FN2">2</xref>

1984 • 21 citations

Natural immunity to tumours – theoretical predictions and biological observations

1985 • 20 citations

Activation of human blood lymphocytes and monocytes by the streptococcal preparation OK432: Enhanced generation of soluble cytotoxic factors

1985 • 20 citations

Suppression of natural killer cell activity by adherent effusion cells of cancer patients. Suppression of motility, binding capacity and lethal hit of NK cells

1984 • 20 citations

Lysis of tumor biopsy cells by blood lymphocyte subsets of various densities. Autologous and allogeneic studies

1984 • 19 citations

Lysis of fresh human tumour cells by autologous tumour-associated lymphocytes: Two distinct types of autologous tumour killer cells induced by co-culture with autologous tumour

1985 • 16 citations

Autologous tumor killing and natural cytotoxic activity of tumor-associated macrophages in cancer patients

1985 • 16 citations

Natural cytotoxicity of human blood monocytes: Production of monocyte cytotoxic factors (MCF) during interaction with tumor cells

1984 • 16 citations

Suppression of T-cell Response in Autologous Mixed Lymphocyte-Tumor Culture by Large Granular Lymphocytes<xref ref-type="fn" rid="FN2">2</xref>

1986 • 16 citations

Natural Killer Inhibitory Substance Produced by the Peritoneal Cells of Patients With Ovarian Cancer<xref ref-type="fn" rid="FN2">2</xref>

1985 • 13 citations

Lysis of autologous tumor cells by high‐density lymphocytes is potentiated by the streptococcal preparation OK432 (picibanil)

1986 • 11 citations

Effector cell sensitivity to sugar moieties: Inhibition of human natural killer cell activity by tunicamycin

1982 • 8 citations

Development of Cytotoxic Cells during in vitro Cultures of Pleural Effusion Lymphocytes from Patients with Lung Cancer

1982 • 2 citations