Intrapleural administration of OK432 in cancer patients: Augmentation of autologous tumor killing activity of tumor-associated large granular lymphocytes

Lymphokine-activated killer cell phenomenon. Lysis of natural killer-resistant fresh solid tumor cells by interleukin 2-activated autologous human peripheral blood lymphocytes.

1982 • 2,228 citations

Clinical studies on cell-mediated immunity in patients with malignant disease I. Effect of immunotherapy with OK-432 on lymphocyte subpopulation and phytomitogen responsivenessin vitro

1980 • 160 citations

Analysis by a single cell cytotoxicity assay of natural killer (NK) cells frequencies among human large granular lymphocytes and of the effects of interferon on their activity.

1982 • 142 citations

Augmentation of Mouse Natural Killer Cell Activity by a Streptococcal Preparation, Ok-432<xref ref-type="fn" rid="fn2">2</xref>

1980 • 142 citations

Lymphocyte cytotoxicity against autologous tumour biopsy cells in humans

1977 • 104 citations

Role of alloantigens in natural killing. Allogeneic but not autologous tumor biopsy cells are sensitive for interferon-induced cytotoxicity of human blood lymphcoytes.

1980 • 100 citations

Intrapleural administration of OK432 in cancer patients: Activation of nk cells and reduction of suppressor cells

1983 • 95 citations

Lysis of fresh human solid tumors by autologous lymphocytes activated in vitro with lectins.

1982 • 94 citations

Lysis of human solid tumors by autologous cells sensitized in vitro to alloantigens.

1981 • 94 citations

Specificity of auto‐tumor cytotoxicity exerted by fresh, activated and propagated human t lymphocytes

1982 • 82 citations

In vitro augmentation of natural killing activity by OK-432

1981 • 75 citations

Lysis of fresh human tumor cells by autologous large granular lymphocytes from peripheral blood and pleural effusions

1983 • 75 citations

Lysis of Fresh Human Tumor Cells by Autologous Peripheral Blood Lymphocytes and Pleural Effusion Lymphocytes Activated by OK432<xref ref-type="fn" rid="FN2">2</xref>

1983 • 74 citations

Modulation of Sensitivity to Natural Killer Cell Lysis After In Vitro Explantation of a Mouse Lymphoma<xref ref-type="fn" rid="FN2">2</xref>

1978 • 69 citations

Activated macrophages are responsible for the tumor-inhibitory effect in mice receiving intravenous injection of OK-432

1984 • 67 citations

Limiting dilution analysis of the frequency of human T cells and large granular lymphocytes proliferating in response to interleukin 2. I. The effect of lectin on the proliferative frequency and cytotoxic activity of cultured lymphoid cells.

1983 • 61 citations

The influence of different isolation procedures and the use of target cells from melanoma cell lines and short‐term cultures on the non‐specific cytotoxic effects of lymphocytes from healthy donors

1975 • 53 citations

Suppressor cells for natural killer activity in carcinomatous pleural effusions of cancer patients

1981 • 49 citations

Natural and activated cytotoxic lymphocytes which act on autologous and allogeneic tumor cells

1981 • 45 citations

Natural killer cells in carcinomatous pleural effusions

1981 • 44 citations

Cytotoxicity of adherent cells associated with some human tumours and lung tissues

1978 • 42 citations

Intraperitoneal administration of corynebacterium parvum in patients with ascitic ovarian tumors resistant to chemotherapy: Effects on cytotoxicity of tumor‐associated macrophages and NK cells

1981 • 38 citations

Reduction of suppressor cells in cancer patients treated with OK-432 immunotherapy

1980 • 38 citations

Lysis of autologous human melanoma cells by in vitro allosensitized peripheral blood lymphocytes

1982 • 34 citations

Effect of a streptococcal preparation (OK432) on natural killer activity of tumour-associated lymphoid cells in human ovarian carcinoma and on lysis of fresh ovarian tumour cells

1983 • 30 citations

Natural Killer Cell Activity and Autologous Tumor Killing Activity in Cancer Patients: Overlapping Involvement of Effector Cells as Determined in Two-Target Conjugate Cytotoxicity Assay<xref ref-type="fn" rid="FN2">2</xref>

1984 • 28 citations

Interferon Effect on Cytotoxicity of Peripheral Blood and Tumor-Associated Lymphocytes Against Human Ovarian Carcinoma Cells<xref ref-type="fn" rid="fn2">2</xref><xref ref-type="fn" rid="fn3">3</xref>

1982 • 26 citations

Studies of the properties of a streptococcal preparation, OK-432 (NSC-B116209), as an immunopotentiator

1982 • 22 citations

Natural cytotoxicity of lymphocytes and monocytes and its augmentation by OK432 in melanoma patients

1984 • 21 citations

Lysis of tumor biopsy cells by blood lymphocyte subsets of various densities. Autologous and allogeneic studies

1984 • 19 citations

Intrapleural administration of OK432: Augmentation of natural killer (NK) activity and reduction of NK suppressor activity

1982 • 5 citations

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