Luminal Ca2+ Protects against Thapsigargin Inhibition in Neuronal Endoplasmic Reticulum

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPase.

1990 • 3,250 citations

Thapsigargin inhibits the sarcoplasmic or endoplasmic reticulum Ca-ATPase family of calcium pumps.

1991 • 1,282 citations

Amino-acid sequence of a Ca2+ + Mg2+ -dependent ATPase from rabbit muscle sarcoplasmic reticulum, deduced from its complementary DNA sequence

1985 • 1,126 citations

Energy Interconversion by the Ca2+-Dependent ATPase of the Sarcoplasmic Reticulum

1979 • 718 citations

Functional comparisons between isoforms of the sarcoplasmic or endoplasmic reticulum family of calcium pumps.

1992 • 649 citations

Inhibition of the sarcoplasmic reticulum Ca2+ transport ATPase by thapsigargin at subnanomolar concentrations

1991 • 452 citations

Localization and quantification of endoplasmic reticulum Ca(2+)-ATPase isoform transcripts

1995 • 341 citations

Identification of intracellular calcium pools. Selective modification by thapsigargin

1991 • 238 citations

Three-dimensional cryo-electron microscopy of the calcium ion pump in the sarcoplasmic reticulum membrane

1993 • 231 citations

Intracellular Ca2+ pools in PC12 cells. Three intracellular pools are distinguished by their turnover and mechanisms of Ca2+ accumulation, storage, and release.

1991 • 171 citations

Characterization of the inhibition of intracellular Ca2+ transport ATPases by thapsigargin.

1992 • 170 citations

Drug action of thapsigargin on the Ca2+ pump protein of sarcoplasmic reticulum.

1991 • 162 citations

High affinity Ca2+-stimulated Mg2+-dependent ATPase in rat brain synaptosomes, synaptic membranes, and microsomes.

1983 • 131 citations

A conformational mechanism for formation of a dead-end complex by the sarcoplasmic reticulum ATPase with thapsigargin.

1992 • 127 citations

Functionally and spatially distinct Ca2+ stores are revealed in cultured vascular smooth muscle cells.

1994 • 101 citations

Nucleotide sequences of avian cardiac and brain SR/ER Ca(2+)-ATPases and functional comparisons with fast twitch Ca(2+)-ATPase. Calcium affinities and inhibitor effects

1991 • 101 citations

The inhibitors thapsigargin and 2,5‐di(tert‐butyl)‐1,4‐benzohydroquinone favour the E2 form of the Ca²⁺, Mg²⁺‐ATPase

1992 • 96 citations

Mechanism of inhibition of the calcium pump of sarcoplasmic reticulum by thapsigargin

1992 • 90 citations

Dynamic Properties of an Inositol 1,4,5-Trisphosphate– and Thapsigargin-insensitive Calcium Pool in Mammalian Cell Lines

1997 • 76 citations

Thapsigargin-resistant Intracellular Calcium Pumps

1995 • 61 citations

Functional identification and quantitation of three intracellular calcium pools in GH4C1 cells: Evidence that the caffeine-responsive pool is coupled to a thapsigargin-resistant, ATP-dependent process

1993 • 59 citations

Identification of a Ca2+-ATPase in cerebellar Purkinje cells

1989 • 47 citations

The Endoplasmic Reticulum in PC12 Cells

1996 • 46 citations

Highly Supralinear Feedback Inhibition of Ca2+ Uptake by the Ca2+ Load of Intracellular Stores

1996 • 44 citations

Thapsigargin-sensitive Ca2+-ATPases account for Ca2+ uptake to inositol 1,4,5-trisphosphate-sensitive and caffeine-sensitive Ca2+ stores in adrenal chromaffin cells

1995 • 44 citations

Rat brain endoplasmic reticulum calcium pools are anatomically and functionally segregated.

1990 • 33 citations

Thapsigargin discriminates strongly between Ca²⁺‐ATPase phosphorylated intermediates with different subcellular distributions in bovine adrenal chromaffin cells

1995 • 25 citations

Calcium chelators enhance 45Ca accumulation in permeablized synaptosomes and in microsomes

1996 • 14 citations

Effects of the intraluminal Ca load on the kinetics of 45Ca uptake and efflux in brain microsomes

1996 • 4 citations