Virulence, Immunity, and Vaccine Related to Streptococcus pneumoniae

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase

1988 • 17,059 citations

HUMAN IMMUNITY TO THE MENINGOCOCCUS

1969 • 1,009 citations

Considerations for Formulating the Second-Generation Pneumococcal Capsular Polysaccharide Vaccine with Emphasis on the Cross-Reactive Types Within Groups

1983 • 560 citations

Use of bacteriolytic enzymes in determination of wall structure and their role in cell metabolism.

1968 • 491 citations

Virulence Factors of Bordetella Pertussis

1986 • 436 citations

HUMAN IMMUNITY TO THE MENINGOCOCCUS

1969 • 401 citations

Mechanism of membrane damage by streptolysin-O

1985 • 398 citations

Antibody Response to Pneumococcal Vaccination in Children Younger than Five Years of Age

1983 • 384 citations

PROTEIN SECRETION IN ESCHERICHIA COLI

1985 • 334 citations

Human Immunoglobulins: Classes, Subclasses, Genetic Variants, and Idiotypes

1973 • 333 citations

Immunization Policies and Vaccine Coverage Among Adults

1988 • 307 citations

Anti-phosphorylcholine antibodies of the T15 idiotype are optimally protective against Streptococcus pneumoniae.

1982 • 303 citations

Choline-containing Teichoic Acid As a Structural Component of Pneumococcal Cell Wall and Its Role in Sensitivity to Lysis by an Autolytic Enzyme

1970 • 301 citations

Sequences required for expression of Bordetella pertussis virulence factors share homology with prokaryotic signal transduction proteins.

1989 • 300 citations

Antigenic modulation ofBordetella pertussis

1960 • 281 citations

Polysaccharide-Protein Conjugates: A New Generation of Vaccines

1990 • 275 citations

Molecular cloning, characterization, and complete nucleotide sequence of the gene for pneumolysin, the sulfhydryl-activated toxin of Streptococcus pneumoniae

1987 • 243 citations

Phase variation in Bordetella pertussis by frameshift mutation in a gene for a novel two-component system

1989 • 241 citations

Clinical evaluation of group A and group C meningococcal polysaccharide vaccines in infants.

1975 • 235 citations

THE ELABORATION OF SPECIFIC SOLUBLE SUBSTANCE BY PNEUMOCOCCUS DURING GROWTH

1917 • 230 citations

THE ENHANCEMENT OF BACTERIAL PHAGOCYTOSIS BY SERUM

1969 • 226 citations

Activation of human complement by the pneumococcal toxin pneumolysin

1984 • 220 citations

Use of insertional inactivation to facilitate studies of biological properties of pneumococcal surface protein A (PspA).

1987 • 214 citations

Effect of immunization with pneumolysin on survival time of mice challenged with Streptococcus pneumoniae

1983 • 205 citations

Assessment of the Antibody Response to Pneumococcal Vaccine in High-Risk Populations

1981 • 202 citations

The effect of variation in molecular weight on the antigenicity of dextran in man

1958 • 195 citations

Natural and Vaccine-Related Immunity to Streptococcus pneumoniae

1986 • 194 citations

Inhibition of human polymorphonuclear leukocyte respiratory burst, bactericidal activity, and migration by pneumolysin

1983 • 181 citations

Structural studies on the specific type-14 pneumococcal polysaccharide

1977 • 172 citations

The Type b Capsular Polysaccharide as a Virulence Determinant of Haemophilus influenzae: Studies Using Clinical Isolates and Laboratory Transformants

1981 • 170 citations

Quantitative Determination of the Human Immune Response to Immunization with Meningococcal Vaccines

1972 • 162 citations

Vaccines for the prevention of encapsulated bacterial diseases: current status, problems and prospects for the future

1978 • 161 citations

Activation of the Alternative Complement Pathway by Pneumococcal Cell Wall Teichoic Acid

1978 • 157 citations

Purification and immunogenicity of genetically obtained pneumolysin toxoids and their conjugation to Streptococcus pneumoniae type 19F polysaccharide

1991 • 154 citations

Structure of the complex polysaccharide C-substance from Streptococcus pneumoniae type 1

1980 • 149 citations

The Autolytic Enzyme System of Streptococcus faecalis. II. Partial Characterization of the Autolysis and Its Substrate^*

1967 • 147 citations

Capsule loss in H. influenzae type b occurs by recombination-mediated disruption of a gene essential for polysaccharide export

1988 • 146 citations

Antibody response to 14-valent pneumococcal capsular polysaccharide vaccine in pre-school age children

1986 • 142 citations

Pneumococcal Forssman Antigen

1973 • 139 citations

Persistence of Antibodies in Human Subjects Injected with Pneumococcal Polysaccharides

1950 • 134 citations

CHEMOIMMUNOLOGICAL STUDIES ON THE SOLUBLE SPECIFIC SUBSTANCE OF PNEUMOCOCCUS

1941 • 132 citations

Specific recognition of choline residues in the cell wall teichoic acid by the N-acetylmuramyl-L-alanine amidase of Pneumococcus.

1975 • 131 citations

GENETIC REGULATION OF BACTERIAL VIRULENCE

1989 • 123 citations

Pneumolysin, the thiol-activated toxin of Streptococcus pneumoniae, does not require a thiol group for in vitro activity

1989 • 122 citations

Genetic analysis of a region of the Bordetella pertussis chromosome encoding filamentous hemagglutinin and the pleiotropic regulatory locus vir

1988 • 120 citations

Immunoglobulin A1 protease production by Haemophilus influenzae and Streptococcus pneumoniae

1979 • 120 citations

Capsular Polysaccharides as Vaccine Candidates

1990 • 113 citations

Structural studies of the capsular polysaccharide from streptococcus pneumoniae type 1

1980 • 113 citations

Comparative efficacy of pneumococcal neuraminidase and pneumolysin as immunogens protective against Streptococcus pneumoniae

1988 • 110 citations

THE INHIBITION OF SURFACE PHAGOCYTOSIS BY THE CAPSULAR "SLIME LAYER" OF PNEUMOCOCCUS TYPE III

1949 • 109 citations

Surface Components of Streptococcus pneumoniae

1981 • 102 citations

Partial Duplication in the “Hinge” Region of IgA ₁ Myeloma Proteins

1972 • 97 citations

The bvgA gene of Bordetella pertussis encodes a transcriptional activator required for coordinate regulation of several virulence genes

1989 • 96 citations

Ultrastructural localization of capsules, cell wall polysaccharide, cell wall proteins, and F antigen in pneumococci

1988 • 96 citations

Does Naturally Acquired IgG Antibody to Cell Wall Polysaccharide Protect Human Subjects against Pneumococcal Infection?

1990 • 95 citations

Binding of cholesterol by sulfhydryl-activated cytolysins

1980 • 94 citations

Complete Covalent Structure of a Human IgA1 Immunoglobulin

1976 • 93 citations

Capsulation and gene copy number at the cap locus of Haemophilus influenzae type b

1988 • 93 citations

Regulation of the Antibody Response to Pneumococcal Polysaccharide by Thymus-Derived Cells

1981 • 93 citations

Genes involved in Haemophilus influenzae type b capsule expression are part of an 18-kilobase tandem duplication.

1986 • 92 citations

The Specific Polysaccharide of Type VI Pneumococcus. II.¹ The Repeating Unit²

1961 • 92 citations

Immunological properties of teichoic acids.

1973 • 89 citations

Random Gleanings from a Life with the Pneumococcus

1975 • 88 citations

Structure of the specific capsular polysaccharide of Streptococcus pneumoniae type 23F (American type 23)

1988 • 86 citations

Inhibition of in vitro human lymphocyte response by the pneumococcal toxin pneumolysin

1984 • 86 citations

Specific Proteolysis of Human IgA by Streptococcus pneumoniae and Haemophilus influenzae

1980 • 85 citations

The Structure of the Type VIII Pneumococcus Specific Polysaccharide^1a,b

1957 • 83 citations

Phase variants of Bordetella bronchiseptica arise by spontaneous deletions in the vir locus

1989 • 80 citations

Regulation of magnitude of antibody response to bacterial polysaccharide antigens by thymus-derived lymphocytes

1990 • 78 citations

IgA proteases of two distinct specificities are released by Neisseria meningitidis.

1980 • 78 citations

Bacterial capsular polysaccharides—biochemistry, immunity and vaccine

1987 • 77 citations

THE ROLE OF AUTOLYSINS IN CELL DEATH*

1974 • 74 citations

Pneumococcal Antibody Levels One Decade After Immunization of Healthy Adults**Mufson MA, Krause HE, Schiffman G, Hughey D: Decline in pneumococcal antibody levels one decade after administration of polysaccharide vaccine. Clin Res 34:222A, 1986.

1987 • 73 citations

Cloning and expression in Escherichia coli of the Streptococcus pneumoniae gene encoding pneumolysin

1986 • 72 citations

Blood clearance by anti-phosphocholine antibodies as a mechanism of protection in experimental pneumococcal bacteremia.

1984 • 71 citations

Cross-reactions between pneumococci and other streptococci due to C polysaccharide and F antigen

1987 • 69 citations

Pneumococcal polysaccharides complexed with C3d bind to human B lymphocytes via complement receptor type 2

1991 • 65 citations

Protection against pneumococcal infection in mice conferred by phosphocholine-binding antibodies: specificity of the phosphocholine binding and relation to several types

1983 • 64 citations

Activation of antigen-specific suppressor T cells by B cells from mice immunized with type III pneumococcal polysaccharide.

1983 • 63 citations

Cross-reactive antigens and immunity to diseases caused by encapsulated bacteria

1975 • 62 citations

Structural studies of the capsular antigen from streptococcus pneumoniae type 26

1979 • 61 citations

The Role of immunological factors in infectious, allergic, and autoimmune processes

1976 • 61 citations

Rabbit antibodies to the cell wall polysaccharide of Streptococcus pneumoniae fail to protect mice from lethal challenge with encapsulated pneumococci

1986 • 55 citations

Purification and immunological characterization of neuraminidase produced by Streptococcus pneumoniae

1988 • 55 citations

Studies on immunological paralysis. V. The influence of molecular weight on the immunogenicity, tolerogenicity and antibody-neutralizing activity of the 3 pneumococcal polysaccharide.

1971 • 54 citations

The effects of idiotype on the ability of IgG₁ antiphosphorylcholine antibodies to protect mice from fatal infection with Streptococcus pneumoniae

1984 • 53 citations

Studies on Pneumococcus vaccine alone or mixed with DTP and on Pneumococcus type 6B and Haemophilis influenzae type b capsular polysaccharide-tetanus toxoid conjugates in two-to five-year-old children with sickle cell anemia

1990 • 52 citations

Inhibition of human monocyte respiratory burst, degranulation, phospholipid methylation and bactericidal activity by pneumolysin.

1986 • 51 citations

Immunization of elderly people with polyvalent pneumococcal vaccine

1989 • 51 citations

Epidemiological studies of Streptococcus pneumoniae in infants: development of antibody to phosphocholine

1983 • 49 citations

Properties of Purified Pneumococcal Hemolysin

1972 • 49 citations

Application of high-resolution n.m.r. spectroscopy to the elucidation of the structure of the specific capsular polysaccharide of streptococcus pneumoniae type 7F

1988 • 49 citations

Characteristics of amplifier T cells involved in the antibody response to the capsular polysaccharide of type III Streptococcus pneumoniae.

1984 • 47 citations

Structural studies of the capsular polysaccharide from Streptococcus pneumoniae type 5

1985 • 46 citations

The structures of the cross-reactive types 19 (19F) and 57 (19A) pneumococcal capsular polysaccharides.

1980 • 46 citations

The specific capsular polysaccharide of Streptococcus pneumoniae type 9V

1981 • 44 citations

Structural studies of the capsular polysaccharide from Streptococcus pneumoniae type 4

1981 • 43 citations

Comparison of Pneumolysin genes and proteins fromStreptococcus pneumoniaetypes 1 and 2

1990 • 43 citations

Naturally Occurring Antibodies to Phosphocholine as a Potential Index of Antibody Responsiveness to Polysaccharides

1987 • 42 citations

Structural studies of the capsular polysaccharide from streptococcus pneumoniae type 2, a reinvestigation

1988 • 39 citations

Immunoglobulin G class and subclass antibodies to pneumococcal capsular polysaccharides

1987 • 38 citations

Peptidoglycan cross-linking and teichoic acid attachment in Streptococcus pneumoniae

1985 • 37 citations

Opsonin-Independent Phagocytosis of Surface-Adherent Bacteria by Human Alveolar Macrophages

1984 • 37 citations

The specific capsular polysaccharide of Streptococcus pneumoniae type 20

1983 • 36 citations

Structural studies of the capsular polysaccharide from Streptococcus pneumoniae Type 12F

1981 • 33 citations

Structural determination of the capsular polysaccharide of Streptococcus pneumoniae type 18C (56)

1984 • 32 citations

Mutations affecting expression and maintenance of genes encoding the serotype b capsule of Haemophilus influenzae

1986 • 31 citations

Structural studies of the capsular polysaccharide from Streptococcus pneumoniae types 15B and 15C

1987 • 31 citations

Capsular polysaccharides of nongroupable streptococci that cross-react with pneumococcal group 19.

1984 • 31 citations

QUANTITATIVE DROP ANALYSIS

1941 • 28 citations

Pneumococcal Forssman antigen: enrichment in mesosomal membranes and specific binding to the autolytic enzyme of Streptococcus pneumoniae

1985 • 27 citations

Structural analysis of the specific capsular polysaccharide of Streptococcuspneumoniae type 22F

1989 • 26 citations

Immunochemical relations between pneumococcal group 19 and Klebsiella capsular polysaccharides.

1981 • 25 citations

Requirements for activation of contrasuppressor T cells by type III pneumococcal polysaccharide.

1986 • 24 citations

Structure of the capsular polysaccharide from Streptococcus pneumoniae type 9

1985 • 24 citations

Analysis of humoral and phagocytic defenses against Streptococcus pneumoniae serotypes 1 and 3.

1988 • 24 citations

Cross-Immunogenicity of Pneumococcal Group 9 Capsular Polysaccharides in Adult Volunteers

1982 • 24 citations

Determination of antibodies to pneumococcal C polysaccharide in patients with community-acquired pneumonia

1985 • 23 citations

Effects of pneumococcal mucopeptide and capsular polysaccharide on phagocytosis

1977 • 23 citations

The quantitative immunochemical determination of pneumococcal and meningococcal capsular polysaccharides by light scattering rate nephelometry

1983 • 22 citations

Autolytic enzyme system from Lactobacillus fermenti

1973 • 19 citations

Antibody responses in adult volunteers to pneumococcal polysaccharide types 19F and 19A administered singly and in combination

1982 • 19 citations

Cross-reactions of polysaccharides of staphylococci and streptococci in antipneumococcal and other antisera

1984 • 17 citations

The specific capsular polysaccharide of Streptococcus pneumoniae type 33F

1984 • 17 citations

Characterization and activity of contrasuppressor T cells induced by type III pneumococcal polysaccharide.

1986 • 17 citations

The structure of the repeating oligosaccharide unit of the pneumococcal capsular polysaccharide type 18C

1983 • 14 citations

Quantitative determination of pneumococcal capsular polysaccharides in the polyvalent vaccine. I. Standardization of an immunoelectrophoretic method

1980 • 13 citations

Generation of purpura-producing principle from pneumococcal cell walls

1985 • 13 citations

The autolytic enzyme activity upon pneumococcal cell wall

1977 • 12 citations

A Study of the Origin of Naturally Occurring Immune Bodies for Pneumococci in Infants

1937 • 11 citations

Production of soluble suppressor factor by spleen cells from mice immunized with type III pneumococcal polysaccharide.

1985 • 11 citations

Elucidation and Comparison of the Chemical Structures of the Specific Capsular Polysaccharides of Streptococcus Pneumoniae Groups 11 (11F, 11B, 11C, And 11A)

1988 • 10 citations

Pneumococcal intracellular killing is abolished by polysaccharide despite serum complement activity

1986 • 8 citations

Induction of Increased Antibody Responses to Pneumococcal Type 19F Polysaccharide by Klebsiella Polysaccharide

1985 • 6 citations