Bcl-2 protein expression: association with p53 and prognosis in colorectal cancer

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

1993 • 6,009 citations

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

1990 • 3,817 citations

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

1993 • 3,465 citations

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

1988 • 3,194 citations

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

1993 • 3,111 citations

Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo.

1994 • 2,141 citations

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

1991 • 2,127 citations

Cloning of the Chromosome Breakpoint of Neoplastic B Cells with the t(14;18) Chromosome Translocation

1984 • 1,761 citations

BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death.

1991 • 1,301 citations

Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation

1986 • 1,232 citations

Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around Jh on chromosome 14 and near a transcriptional unit on 18

1985 • 1,188 citations

Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma.

1986 • 1,118 citations

Nucleotide sequence of a t(14;18) chromosomal breakpoint in follicular lymphoma and demonstration of a breakpoint-cluster region near a transcriptionally active locus on chromosome 18.

1985 • 972 citations

Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line.

1992 • 871 citations

bcl-2 Protein in Non-Small-Cell Lung Carcinoma

1993 • 684 citations

bcl-2 and p53 oncoprotein expression during colorectal tumorigenesis.

1995 • 578 citations

An evaluation of six antibodies for immunohistochemistry of mutant p53 gene product in archival colorectal neoplasms

1994 • 513 citations

Down-regulation of bcl-2 by p53 in breast cancer cells.

1994 • 479 citations

bcl-2 in normal human breast and carcinoma, association with oestrogen receptor-positive, epidermal growth factor receptor-negative tumours and in situ cancer

1994 • 326 citations

Expression of bcl-2 in fetal tissues suggests a role in morphogenesis.

1993 • 320 citations

Expression in Non-Hodgkin's Lymphoma of thebcl-2 Protein Associated with the t(14;18) Chromosomal Translocation

1988 • 292 citations

BCL‐2 expression in adult and embryonic non‐haematopoietic tissues

1993 • 265 citations

Expression of the apoptosis-suppressing protein bcl-2, in neuroblastoma is associated with unfavorable histology and N-myc amplification.

1993 • 262 citations

p53 point mutation and survival in colorectal cancer patients.

1995 • 240 citations

Apoptosis and immunohistochemicalbcl-2 expression in colorectal adenomas and carcinomas: Aspects of carcinogenesis and prognostic significance

1996 • 224 citations

Regulation of bcl-2 Proto-Oncogene Expression During Normal Human Lymphocyte Proliferation

1987 • 202 citations

Characterization of the protein product of bcl-2, the gene involved in human follicular lymphoma.

1987 • 191 citations

Paradoxical inhibition of solid tumor cell growth by bcl2.

1994 • 190 citations

Wild-type p53-triggered apoptosis is inhibited by bcl-2 in a v-myc-induced T-cell lymphoma line.

1993 • 177 citations

Prognostic significance of Bcl-2 expression and p53 nuclear accumulation in colorectal adenocarcinoma

1997 • 171 citations

bcl-2 oncoprotein in colorectal hyperplastic polyps, adenomas, and adenocarcinomas

1995 • 170 citations

BCL-2 expression in human colorectal adenomas and carcinomas.

1994 • 168 citations

Immunohistochemically detectable bcl-2 expression in colorectal carcinoma: correlation with tumour stage and patient survival

1995 • 131 citations

Evidence for reciprocity of bcl-2 and p53 expression in human colorectal adenomas and carcinomas

1996 • 126 citations

EARLY EXPRESSION OF bcl-2 PROTEIN IN THE ADENOMA-CARCINOMA SEQUENCE OF COLORECTAL NEOPLASIA

1996 • 60 citations

Bcl-2 expression and response to chemotherapy in colorectal adenocarcinomas

1997 • 47 citations

Prognostic markers for colorectal cancer: Expression of P53 and BCL2

1997 • 46 citations

DETECTION OF p53 AND bcl-2 PROTEIN IN CARCINOMA OF THE RENAL PELVIS AND URETER INCLUDING DYSPLASIA

1996 • 32 citations

An immunohistochemical study of the simultaneous expression of bcl-2 and p53 oncoproteins in epithelial tumors of the colon and rectum.

1996 • 29 citations

Bcl-2 protein in non-small-cell lung carcinoma. Immunohistochemical evidence of abnormal expression and correlation with survival

1994 • 1 citations