Endothelial Nitric Oxide Synthase Intron 4 Polymorphism Influences the Progression of Renal Disease

Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.

1990 • 3,304 citations

Hypertension in mice lacking the gene for endothelial nitric oxide synthase

1995 • 2,075 citations

NO at work

1994 • 1,493 citations

Structure and chromosomal localization of the human constitutive endothelial nitric oxide synthase gene

1993 • 881 citations

Chronic blockade of nitric oxide synthesis in the rat produces systemic hypertension and glomerular damage.

1992 • 740 citations

A smoking–dependent risk of coronary artery disease associated with a polymorphism of the endothelial nitric oxide synthase gene

1996 • 571 citations

Control of regional blood flow by endothelium-derived nitric oxide.

1990 • 447 citations

Role of endothelium-derived relaxing factor in regulation of renal hemodynamic responses

1990 • 250 citations

Gene Structure, Polymorphism and Mapping of the Human Endothelial Nitric Oxide Synthase Gene

1994 • 230 citations

Effects of acute nitric oxide inhibition on rat glomerular microcirculation

1991 • 189 citations

Cloning and structural characterization of the human endothelial nitric‐oxide‐synthase gene

1994 • 157 citations

Reduced Plasma Concentrations of Nitrogen Oxide in Individuals With Essential Hypertension

1997 • 157 citations

Nitric Oxide Modulates the Synthesis of Extracellular Matrix Proteins in Cultured Rat Mesangial Cells

1995 • 142 citations

Nitric Oxide Stimulates the Activity of a 72-kDa Neutral Matrix Metalloproteinase in Cultured Rat Mesangial Cells

1996 • 110 citations

Endothelial nitric oxide synthase gene polymorphism in intron 4 affects the progression of renal failure in non-diabetic renal diseases

1999 • 76 citations

Attenuated glomerular cGMP production and renal vasodilation in streptozotocin-induced diabetic rats

1993 • 58 citations

High glucose inhibits nitric oxide production in cultured rat mesangial cells.

1997 • 54 citations

Effect of a polymorphism of endothelial nitric oxide synthase gene in Japanese patients with IgA nephropathy.

1999 • 30 citations

An Intron 4 Gene Polymorphism in Endothelial Cell Nitric Oxide Synthase Might Modulate Volume-Dependent Hypertension in Patients on Hemodialysis

2000 • 16 citations