Amplified dihydrofolate reductase genes are located in chromosome regions containing DNA that replicates during the first half of S-phase.

Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I

1977 • 12,015 citations

Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate.

1979 • 3,525 citations

Kinetics of renaturation of DNA

1968 • 1,446 citations

Selective multiplication of dihydrofolate reductase genes in methotrexate-resistant variants of cultured murine cells.

1978 • 972 citations

On the mechanism of DNA replication in mammalian chromosomes

1968 • 950 citations

Microfluorometric Detection of Deoxyribonucleic Acid Replication in Human Metaphase Chromosomes

1973 • 838 citations

Localization of single copy DNA sequences on G-banded human chromosomes by in situ hybridization

1981 • 836 citations

Asynchronous Duplication of Chromosomes in Cultured Cells of Chinese Hamster

1960 • 530 citations

Eucaryotic DNA: Organization of the genome for replication

1978 • 476 citations

EUKARYOTIC CHROMOSOME REPLICATION

1975 • 455 citations

Phenotypic expression in E. coli of a DNA sequence coding for mouse dihydrofolate reductase

1978 • 426 citations

Metaphase Chromosome Anomaly: Association with Drug Resistance and Cell-Specific Products

1976 • 396 citations

Amplified dihydrofolate reductase genes are localized to a homogeneously staining region of a single chromosome in a methotrexate-resistant Chinese hamster ovary cell line.

1978 • 393 citations

Amplified dihydrofolate reductase genes in unstably methotrexate-resistant cells are associated with double minute chromosomes.

1979 • 376 citations

Localization of the human insulin gene to the distal end of the short arm of chromosome 11.

1981 • 285 citations

Structure and genomic organization of the mouse dihydrofolate reductase gene

1980 • 218 citations

A Novel Chromosome Abnormality in Human Neuroblastoma and Antifolate-Resistant Chinese Hamster Cell Lines in Culture 1 2

1976 • 213 citations

Correlation of dihydrofolate reductase elevation with gene amplification in a homogeneously staining chromosomal region in L5178Y cells.

1979 • 185 citations

Methotrexate-resistant Chinese hamster ovary cells have amplified a 135-kilobase-pair region that includes the dihydrofolate reductase gene.

1981 • 175 citations

Synthesis and degradation of folate reductase in sensitive and methotrexate-resistant lines of S-180 cells.

1976 • 171 citations

Regulation of DNA replication on subchromosomal units of mammalian cells.

1975 • 141 citations

Early- and late-replicating deoxyribonucleic acid complexes in HeLa nuclei

1966 • 137 citations

Deoxyribonucleic acid replication in synchronized cultured mammalian cells

1970 • 136 citations

DNA REPLICATION: DIRECTION AND RATE OF CHAIN GROWTH IN MAMMALIAN CELLS

1973 • 113 citations

DNA replication patterns of human chromosomes from fibroblasts and amniotic fluid cells revealed by a Giemsa staining technique

1975 • 110 citations

Direction of DNA replication in mammalian cells

1973 • 108 citations

High-resolution chromosome analysis in clinical medicine.

1978 • 103 citations

Regulation of folate reductase synthesis in sensitive and methotrexate-resistant sarcoma 180 cells. In vitro translation and characterization of folate reductase mRNA.

1976 • 97 citations

Regulation of dihydrofolate reductase gene expression in mouse fibroblasts during the transition from the resting to growing state

1978 • 89 citations

Polyoma virus and cyclic AMP-mediated control of dihydrofolate reductase mRNA abundance in methotrexate-resistant mouse fibroblasts.

1979 • 89 citations

Giemsa staining of the sites replicating DNA early in human lymphocyte chromosomes

1975 • 85 citations

Fluorescence analysis of late DNA replication in human metaphase chromosomes

1975 • 84 citations

Density gradient analysis of newly replicated DNA from synchronized mouse lymphoma cells

1971 • 79 citations

Replication of alpha and beta globin DNA sequences occurs during early S phase in murine erythroleukemia cells.

1981 • 71 citations

alpha-Globulin sequences are located in a region of early-replicating DNA in murine erythroleukemia cells.

1981 • 71 citations

The temporal replication of ribosomal genes in synchronized chinese hamster cells

1974 • 69 citations

Regulation of dihydrofolate reductase synthesis in an overproducing 3T6 cell line during transition from resting to growing state

1979 • 59 citations

The Duration of Replication of the Inactive X Chromosome in Humans Based on the Persistence of the Heterochromatic Sex Chromatin Body During DNA Synthesis

1967 • 59 citations

Localization of sequences specifying messenger RNA to light-staining G-bands of human chromosomes

1977 • 58 citations

Shift in buoyant density of DNA during the synthetic period and its relation to euchromatin and heterochromatin in mammalian cells

1971 • 53 citations

Purification and characterization of covalently closed replicative intermediates of ColEl DNA from Escherichia coli

1977 • 50 citations

A high resolution study of the DNA replication patterns of Chinese hamster chromosomes using sister chromatid differential staining technique

1975 • 47 citations

Traitements discontinus par le BrdU et coloration par l'acridine orange: obtention de marquages R, Q et interm�diaires

1975 • 43 citations

Replication pattern of a large homogenously staining chromosome region in antifolate‐resistant Chinese hamster cell lines

1981 • 38 citations

Effects of controlled exposure of L cells to bromodeoxyuridine (BUdR)

1977 • 34 citations

The effect of polyoma virus, serum factors, and dibutyryl cyclic AMP on dihydrofolate reductase synthesis, and the entry of quiescent cells into S phase

1981 • 28 citations

Sequence programming of DNA replication over the S phase of Chinese hamster cells

1977 • 27 citations

Late DNA replication pattern in human haemopoietic cells

1968 • 26 citations

Replication of repeated DNA in human cells

1974 • 11 citations

Ordered replication of DNA sequences: Synthesis of mouse satellite and adjacent main band sequences

1979 • 8 citations

Replication pattern of the X and Y chromosomes in partially synchronized human lymphocyte cultures

1972 • 3 citations