Regulatory gene evolution: Adaptive differences in expression of alcohol dehydrogenase in Drosophila melanogaster and Drosophila simulans

Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.

1980 • 8,711 citations

RNA molecular weight determinations by gel electrophoresis under denaturing conditions, a critical reexamination

1977 • 3,548 citations

Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonuclease-digested hybrids

1977 • 3,019 citations

Evolution at Two Levels in Humans and Chimpanzees

1975 • 2,796 citations

Biochemical Evolution

1977 • 1,283 citations

Isolation and partial characterization of the Drosophila alcohol dehydrogenase gene.

1980 • 570 citations

Evolution of a Gene

1975 • 554 citations

The messenger RNA for alcohol dehydrogenase in Drosophila melanogaster differs in its 5′ end in different developmental stages

1983 • 415 citations

The contribution of ecological genetics to evolutionary theory: detecting the direct effects of natural selection on particular polymorphic loci.

1975 • 249 citations

Alcohol tolerance: An ecological parameter in the relative success of Drosophila melanogaster and Drosophila simulans

1972 • 211 citations

The complete amino acid sequence of three alcohol dehydrogenase alleloenzymes (AdhN-11, AdhS and AdhUF) from the fruitfly Drosophila melanogaster

1980 • 180 citations

The Alcohol Dehydrogenase Polymorphism in Drosophila melanogaster

1982 • 173 citations

Quantitative genetic variation of enzyme activities in natural populations of Drosophila melanogaster

1980 • 156 citations

Alcohol dehydrogenase gene of Drosophila melanogaster: relationship of intervening sequences to functional domains in the protein.

1981 • 138 citations

Adaptive response due to changes in gene regulation: a study with Drosophila.

1977 • 135 citations

Biological role of alcohol dehydrogenase in the tolerance of Drosophila melanogaster to aliphatic alcohols: Utilization of an ADH-null mutant

1976 • 129 citations

Adaptive significance of differences in the tissue-specific expression of a phosphoglucomutase gene in rainbow trout.

1983 • 110 citations

Genetic regulation and the fossil record.

1975 • 85 citations

Evidence for the adaptive significance of enzyme activity levels: Interspecific variation in ?-GPDH and ADH in Drosophila

1976 • 76 citations

THE GENETICS OF A SMALL AUTOSOMAL REGION OF DROSOPHILA MELANOGASTER CONTAINING THE STRUCTURAL GENE FOR ALCOHOL DEHYDROGENASE. II. LETHAL MUTATIONS IN THE REGION

1979 • 76 citations

Evolution of patterns of gene expression in Hawaiian picture-wingedDrosophila

1980 • 76 citations

GENETIC AND CYTOGENETIC ANALYSIS OF THE ADH REGION IN DROSOPHILA MELANOGASTER

1977 • 72 citations

Alcohol dehydrogenase in Drosophila: isolation and characterization of messenger RNA and cDNA clone

1980 • 68 citations

THE GENETICS OF A SMALL AUTOSOMAL REGION OF DROSOPHILA MELANOGASTER CONTAINING THE STRUCTURAL GENE FOR ALCOHOL DEHYDROGENASE. I. CHARACTERIZATION OF DEFICIENCIES AND MAPPING OF ADH AND VISIBLE MUTATIONS

1979 • 66 citations

Regulation of the tissue specificity of an enzyme by a cis-acting genetic element: evidence from interspecific Drosophila hybrids.

1979 • 60 citations

Regulatory gene adaptation: An evolutionary model

1980 • 60 citations

Regulatory Genes and Adaptation

1982 • 50 citations

Complex cis‐acting regulatory genes demonstrated in Drosophila hybrids

1979 • 48 citations

Continuous variation: Possible role of regulatory genes

1980 • 40 citations

GENE REGULATION IN ADAPTIVE EVOLUTION

1978 • 36 citations

Selectivity of proteases as a basis for tissue distribution of enzymes in hereditary deficiencies.

1983 • 36 citations

Environmental factors affecting the quantity of alcohol dehydrogenase in Drosophila melanogaster

1979 • 36 citations

Genetic tolerance to ethanol in drosophila melanogaster: Increase by selection and analysis of correlated responses

1977 • 35 citations

A Cis-acting regulator of enzyme tissue specificity in Drosophila is expressed at the RNA level

1981 • 21 citations

Tissue-specific allelic isozyme patterns and cis-acting developmental regulators.

1983 • 16 citations