Control of T‐Cell Development by the Pre‐T and αβ T‐Cell Receptor

Altering the Genome by Homologous Recombination

1989 • 2,021 citations

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

1988 • 1,711 citations

The clonal selection theory of acquired immunity

1959 • 1,576 citations

GERM-LINE TRANSFORMATION OF MICE

1986 • 1,165 citations

Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages

1992 • 1,116 citations

On the thymus in the differentiation of "H-2 self-recognition" by T cells: evidence for dual recognition?

1978 • 870 citations

Evidence for a differential avidity model of T cell selection in the thymus

1994 • 679 citations

Genes and Antibodies

1959 • 675 citations

Thymic major histocompatibility complex antigens and the αβ T-cell receptor determine the CD4/CD8 phenotype of T cells

1988 • 671 citations

Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor

1989 • 646 citations

Developmental Biology of T Cells in T Cell-Receptor Transgenic Mice

1990 • 637 citations

Positive selection of antigen-specific T cells in thymus by restricting MHC molecules

1988 • 618 citations

Selective expression of an antigen receptor on CD8-bearing T lymphocytes in transgenic mice

1988 • 505 citations

Thymic selection of CD8+ single positive cells with a class II major histocompatibility complex-restricted receptor.

1994 • 418 citations

Analysis and Expression of a Cloned Pre-T Cell Receptor Gene

1994 • 410 citations

Restoration of T Cell Development in RAG-2-Deficient Mice by Functional TCR Transgenes

1993 • 403 citations

Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand

1989 • 386 citations

In transgenic mice the introduced functional T cell receptor β gene prevents expression of endogenous β genes

1988 • 374 citations

Major histocompatibility complex-linked immune-responsiveness is acquired by lymphocytes of low-responder mice differentiating in thymus of high-responder mice.

1978 • 353 citations

A novel disulfide-linked heterodimer on pre—T cells consists of the T cell receptor β chain and a 33 kd glycoprotein

1993 • 333 citations

A dominant-negative transgene defines a role for p56lck in thymopoiesis.

1993 • 306 citations

T cell receptor β chain gene rearrangement and selection during thymocyte development in adult mice

1994 • 305 citations

Another view of the selective model of thymocyte selection

1993 • 280 citations

Clonal deletion of immature CD4+8+ thymocytes in suspension culture by extrathymic antigen-presenting cells

1991 • 249 citations

Evidence for a stochastic mechanism in the differentiation of mature subsets of T lymphocytes

1993 • 228 citations

Positive selection of CD8+ T cells induced by major histocompatibility complex binding peptides in fetal thymic organ culture.

1993 • 221 citations

The generation of mature T cells requires interaction of the αβ T-cell receptor with major histocompatibility antigens

1989 • 219 citations

Restoration of early thymocyte differentiation in T-cell receptor beta-chain-deficient mutant mice by transmembrane signaling through CD3 epsilon.

1993 • 214 citations

Rearrangement and diversity of T cell receptor β chain genes in thymocytes: A critical role for the β chain in development

1993 • 198 citations

Positive selection of transgenic receptor-bearing thymocytes by Kb antigen is altered by Kb mutations that involve peptide binding.

1990 • 170 citations

An activated Ick transgene promotes thymocyte development in rag-1 mutant mice

1994 • 157 citations

CD3 components at the surface of pro‐T cells can mediate pre‐T cell development in vivo

1994 • 156 citations

A one-receptor view of T-cell behaviour

1981 • 146 citations

T cell receptor (TCR) beta chain homodimers on the surface of immature but not mature alpha, gamma, delta chain deficient T cell lines.

1992 • 137 citations

Surface expression of the beta T cell receptor (TCR) chain in the absence of other TCR or CD3 proteins on immature T cells.

1991 • 121 citations

The selection of the α,β heterodimeric T-cell receptor for antigen

1986 • 100 citations

Regulation of thymocyte development through CD3. I. Timepoint of ligation of CD3 epsilon determines clonal deletion or induction of developmental program.

1993 • 98 citations

I-E expression and susceptibility to parasite infection

1987 • 84 citations

Early expression of a T-cell receptor beta-chain transgene suppresses rearrangement of the V gamma 4 gene segment.

1988 • 61 citations

T cell receptor β chain dimers on immature thymocytes from normal mice

1993 • 57 citations

Stochastic component to development of class I major histocompatibility complex-specific T cells.

1994 • 54 citations

Mutations in the major histocompatibility complex class I antigen‐presenting groove affect both negative and positive selection of T cells

1990 • 54 citations

A human CD4 transgene rescues CD4⁻CD8⁺ cells in β2‐microglobulin‐deficient mice

1994 • 35 citations

T cells respond preferentially to antigens that are similar to self H-2.

1981 • 30 citations

Suppression of T cells specific for the nonthymic parental H-2 haplotype in thymus-grafted chimeras.

1980 • 29 citations

Small CD4+8+TCRlow thymocytes contain precursors of mature T cells

1994 • 24 citations

Central tolerance: Clonal deletion or clonal arrest?

1994 • 13 citations