Small CD4+8+TCRlow thymocytes contain precursors of mature T cells

Induction by Antigen of Intrathymic Apoptosis of CD4 ⁺ CD8 ⁺ TCR ^lo Thymocytes in Vivo

1990 • 1,781 citations

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

1988 • 1,711 citations

Positive and negative selection of an antigen receptor on T cells in transgenic mice

1988 • 758 citations

Thymic major histocompatibility complex antigens and the αβ T-cell receptor determine the CD4/CD8 phenotype of T cells

1988 • 671 citations

Positive selection of antigen-specific T cells in thymus by restricting MHC molecules

1988 • 618 citations

Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand

1989 • 386 citations

Kinetics and efficacy of positive selection in the thymus of normal and T cell receptor transgenic mice

1991 • 368 citations

Exclusion and inclusion of α and β T cell receptor alleles

1992 • 346 citations

Clonal deletion of immature CD4+8+ thymocytes in suspension culture by extrathymic antigen-presenting cells

1991 • 249 citations

Multiple rearrangements in T cell receptor alpha chain genes maximize the production of useful thymocytes.

1993 • 247 citations

CD 69 expression during selection and maturation of CD4⁺8⁺ thymocytes

1993 • 242 citations

The Development of Functionally Responsive T Cells

1992 • 169 citations

Engagement of the T-cell receptor during positive selection in the thymus down-regulates RAG-1 expression.

1992 • 152 citations

Intrathymic maturation of murine T lymphocytes from CD8+ precursors.

1989 • 134 citations

Recognition and Regulation in Cell-Mediated Immunity

1985 • 79 citations

Phenotypic changes accompanying positive selection of CD4⁺CD8⁺ thymocytes

1992 • 64 citations

Mucosal Immunity: IgA and Polymorphonuclear Neutrophils

1986 • 47 citations

Positive selection is an early event in thymocyte differentiation: high TCR expression by cycling immature thymocytes precedes final maturation by several days

1990 • 27 citations

Positive Selection of Immature αβ T Cells

1993 • 24 citations