Human papillomavirus in head and neck squamous cell carcinoma: are some head and neck cancers a sexually transmitted disease?

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

Prevalence of Human Papillomavirus in Cervical Cancer: a Worldwide Perspective

1995 • 3,371 citations

Association of Human Papillomavirus Types 16 and 18 E6 Proteins with p53

1990 • 2,587 citations

Cancer statistics, 1998

1998 • 2,407 citations

The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

1993 • 2,329 citations

NATURAL HISTORY OF CERVICOVAGINAL PAPILLOMAVIRUS INFECTION IN YOUNG WOMEN

1998 • 1,885 citations

Preferential Formation of Benzo[ a ]pyrene Adducts at Lung Cancer Mutational Hotspots in P53

1996 • 1,636 citations

E2F: a Link Between the Rb Tumor Suppressor Protein and Viral Oncoproteins

1992 • 1,552 citations

Structure and transcription of human papillomavirus sequences in cervical carcinoma cells

1985 • 1,481 citations

Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product.

1989 • 1,186 citations

Role of a p53 polymorphism in the development of human papilloma-virus-associated cancer

1998 • 976 citations

Telomerase activation by the E6 gene product of human papillomavirus type 16

1996 • 825 citations

Role of the p16 tumor suppressor gene in cancer.

1998 • 710 citations

Association between Cigarette Smoking and Mutation of the p53 Gene in Squamous-Cell Carcinoma of the Head and Neck

1995 • 664 citations

Oral Cancer Risk in Relation to Sexual History and Evidence of Human Papillomavirus Infection

1998 • 591 citations

Smoking and drinking in relation to cancers of the oral cavity, pharynx, larynx, and esophagus in northern Italy.

1990 • 589 citations

Human papillomavirus 16 E6 expression disrupts the p53-mediated cellular response to DNA damage.

1993 • 526 citations

Inhibition of CDK activity and PCNA-dependent DNA replication by p21 is blocked by interaction with the HPV-16 E7 oncoprotein

1997 • 506 citations

The human papillomavirus E7 oncoprotein can uncouple cellular differentiation and proliferation in human keratinocytes by abrogating p21^Cip1-mediated inhibition of cdk2

1997 • 461 citations

Structure of the retinoblastoma tumour-suppressor pocket domain bound to a peptide from HPV E7

1998 • 450 citations

Epidemiology and prevention of oral cancer

1997 • 441 citations

Human papillomavirus (HPV) in head and neck cancer

1997 • 373 citations

Differential disruption of genomic integrity and cell cycle regulation in normal human fibroblasts by the HPV oncoproteins.

1994 • 371 citations

THE INVASIVE POTENTIAL OF CARCINOMA IN SITU OF THE CERVIX

1979 • 360 citations

Allelotype of head and neck squamous cell carcinoma.

1994 • 349 citations

p53-dependent G1 arrest involves pRB-related proteins and is disrupted by the human papillomavirus 16 E7 oncoprotein.

1994 • 347 citations

Viral etiology of juvenile- and adult-onset squamous papilloma of the larynx.

1982 • 344 citations

Second Cancers Following Radiation Treatment for Cervical Cancer. An International Collaboration Among Cancer Registries

1985 • 321 citations

Human Papillomavirus and head and neck cancer: Epidemiology and molecular biology

1998 • 302 citations

Etiological involvement of oncogenic human papillomavirus in tonsillar squamous cell carcinomas lacking retinoblastoma cell cycle control.

1998 • 279 citations

Identification of Tobacco- Specific Carcinogen in the Cervical Mucus of Smokers and Nonsmokers

1997 • 251 citations

Basaloid and Warty Carcinomas of the Vulva

1993 • 245 citations

Growth arrest by induction of p53 in DNA damaged keratinocytes is bypassed by human papillomavirus 16 E7.

1994 • 243 citations

Human papillomavirus expression in oral mucosa, premalignant conditions, and squamous cell carcinoma

1996 • 241 citations

Continued expression of HPV-16 E7 protein is required for maintenance of the transformed phenotype of cells co-transformed by HPV-16 plus EJ-ras.

1989 • 227 citations

Detection of human papillomavirus DNA and oncoprotein overexpression are associated with distinct morphological patterns of tonsillar squamous cell carcinoma.

1998 • 221 citations

Basal and human papillomavirus E6 oncoprotein-induced degradation of Myc proteins by the ubiquitin pathway

1998 • 219 citations

Association of Papillomavirus With Cancers of the Head and Neck

1989 • 217 citations

Occurrence of p53 gene deletions and human papilloma virus infection in human head and neck cancer.

1992 • 215 citations

Human papillomavirus and risk of oral cancer

1998 • 210 citations

Human papillomaviruses in 91 oral cancers from indian betel quid chewers—high prevalence and multiplicity of infections

1995 • 199 citations

An allelotype of squamous carcinoma of the head and neck using microsatellite markers.

1994 • 195 citations

Human papillomavirus and cancers of the upper aerodigestive tract: a review of epidemiological and experimental evidence.

1996 • 194 citations

p53 codon 72 polymorphism and risk of cervical cancer in UK

1998 • 191 citations

p53 inactivation by HPV16 E6 results in increased mutagenesis in human cells.

1995 • 190 citations

Prevalence and expression of human papillomavirus in tonsillar carcinomas, indicating a possible viral etiology

1992 • 186 citations

Analysis of the p53-mediated G1 growth arrest pathway in cells expressing the human papillomavirus type 16 E7 oncoprotein

1997 • 183 citations

Heterogeneous Etiology of Squamous Carcinoma of the Vulva

1996 • 176 citations

Human Papillomaviruses, Herpes Simplex Viruses, and the Risk of Oral Cancer in Men

1992 • 170 citations

Low risk of perinatal transmission of human papillomavirus: Results from a prospective cohort study

1998 • 166 citations

HPV 16 and cigarette smoking as risk factors for high-grade cervical intra-epithelial neoplasia

1998 • 160 citations

Second Primary Cancers following Anal and Cervical Carcinoma: Evidence of Shared Etiologic Factors

1992 • 144 citations

Human papillomavirus DMA in oral squamous cell carcinomas and normal mucosa

1994 • 138 citations

Molecular genetics of head and neck cancer

1995 • 130 citations

Prevalence of mucosotropic human papillomaviruses in squamous-cell carcinomas of the head and neck

1996 • 129 citations

Integrated human papillomavirus type 16 and loss of heterozygosity at 11q22 and 18q21 in an oral carcinoma and its derivative cell line.

1995 • 129 citations

Human Papillomavirus in Head and Neck Squamous Cell Carcinomas in Nonsmokers

1997 • 128 citations

Genomic alterations associated with malignancy in head and neck cancer

1998 • 125 citations

Human papillomaviruses in normal oral mucosa: a comparison of methods for sample collection

1992 • 122 citations

No evidence of correlation between polymorphism at codon 72 of p53 and risk of cervical cancer in Japanese patients with human papillomavirus 16/18 infection.

1998 • 118 citations

Human papillomavirus type 16 E6 and E7 oncogenes abrogate radiation-induced DNA damage responses in vivo through p53-dependent and p53-independent pathways

1998 • 117 citations

Southern blot hybridization and PCR in detection of oral human papillomavirus (HPV) infections in women with genital HPV infections

1992 • 116 citations

Detection of human papillomavirus type 16 DNA in carcinomas of the palatine tonsil.

1990 • 111 citations

Induction of chromosome abnormalities in mouse and human epidermal keratinocytes by the human papillomavirus type 16 E7 oncogene

1991 • 101 citations

Interactions of the human papillomavirus E7 protein with cell cycle regulators

1996 • 96 citations

High prevalence of human papillomavirus infection and possible association with betel quid chewing and smoking in oral epidermoid carcinomas in taiwan

1989 • 95 citations

Presence of hpv 16 sequences in laryngeal carcinomas

1990 • 95 citations

Combined oral carcinogenicity of HPV-16 and benzo(a)pyrene: an in vitro multistep carcinogenesis model.

1995 • 93 citations

Mutations in the p53 gene and human papillomavirus infection as significant prognostic factors in squamous cell carcinomas of the oral cavity.

1996 • 90 citations

Immortalization and Transformation of Human Cells by Human Papillomavirus

1994 • 87 citations

A possible role for human papillomaviruses in head and neck cancer

1996 • 86 citations

Detection of human papillomavirus (HPV) DNA in oral squamous cell carcinomas by in situ hybridization and polymerase chain reaction

1990 • 80 citations

Antibodies to human papillomavirus 16 and subsequent in situ or invasive cancer of the cervix.

1997 • 78 citations

The disruption of cell cycle checkpoints by papillomavirus oncoproteins contributes to anogenital neoplasia

1996 • 72 citations

Recombinant retroviruses encoding human papillomavirus type 18 E6 and E7 genes stimulate proliferation and delay differentiation of human keratinocytes early after infection.

1992 • 71 citations

HPV detection using "hot start" polymerase chain reaction in patients with oral cancer: a clinicopathological study of 64 patients.

1994 • 70 citations

Mechanism of HPV E6 proteins in cellular transformation

1996 • 70 citations

p53 alteration and human papilloma virus infection in paranasal sinus cancer

1997 • 66 citations

Polymerase chain reaction (PCR) identification of human papillomavirus (HPV) DNA in verrucous carcinoma of the larynx

1993 • 66 citations

Human Papillomavirus Infection in the Malignant and Premalignant Head and Neck Epithelium

1995 • 66 citations

In situ DNA hybridization analysis of human papillomavirus (HPV) sequences in benign oral mucosal lesions

1987 • 61 citations

Analysis of Prevalence of Human Papillomavirus in Laryngeal Carcinomas Study of 40 Cases Using Polymerase Chain Reaction and Consensus Primers

1993 • 59 citations

Human papillomavirus (HPV) type 16 and 33 E6/E7 region transcripts in tonsillar carcinomas can originate from integrated and episomal HPV DNA

1992 • 59 citations

Oral mucosal changes in women with genital HPV infection

1990 • 56 citations

Interaction of HPV-18 and nitrosomethylurea in the induction of squamous cell carcinoma

1993 • 54 citations

Induction of apoptosis in human keratinocytes containing mutated p53 alleles and its inhibition by both the E6 and E7 oncoproteins

1998 • 53 citations

HPV detection in children prior to sexual debut

1997 • 52 citations

Carcinoma of the Larynx After Irradiation for Papilloma

1960 • 51 citations

HPV-16 oncogenes E6 and E7 are mutagenic in normal human oral keratinocytes

1997 • 50 citations

Analysis of p53 status in tonsillar carcinomas associated with human papillomavirus

1994 • 48 citations

Expression of p53 protein related to the presence of human papillomavirus infection in precancer lesions of the larynx.

1995 • 44 citations

Integration of human papillomavirus type 6a DNA in a tonsillar carcinoma: chromosomal localization and nucleotide sequence of the genomic target region.

1994 • 40 citations

Sensitivity of p53 Lysine Mutants to Ubiquitin-Directed Degradation Targeted by Human Papillomavirus E6

1996 • 37 citations

Second primary cancers in patients with carcinoma in situ of the uterine cervix. The norwegian experience 1970–1992

1995 • 37 citations

Trends in cancer mortality, 1955–1989: Asia, Africa and Oceania

1993 • 32 citations

Human papillomavirus DNA in oral squamous cell carcinomas from an African population sample.

1996 • 31 citations

Correlation between HPV types associated with oral squamous cell carcinoma and cervicovaginal cytology

1998 • 31 citations

Presence of Human Papillomavirus in Squamous Cell Laryngeal Carcinomas. A study of Thirty-nine Cases Using Polymerase Chain Reaction and in situ Hybridization

1996 • 28 citations

p53 mutations in relation to human papillomavirus type 16 infection in squamous cell carcinomas of the head and neck

1997 • 28 citations

Oncogenic transformation of HPV-immortalized human oral keratinocytes is associated with the genetic instability of cells.

1996 • 26 citations

New HPV E6 binding proteins: dangerous liaisons?

1998 • 23 citations

Comparison of human papillomavirus type 18 (HPV-18) E6-mediated degradation of p53 in vitro and in vivo reveals significant differences based on p53 structure and cell type but little difference with respect to mutants of HPV-18 E6.

1998 • 22 citations

The prevalence of different human papillomavirus types and p53 mutations in laryngeal carcinomas: Is there a reciprocal relationship?

1995 • 17 citations

Comparison of Virapap filter hybridization with polymerase chain reaction and Southern blot hybridization methods for detection of human papillomavirus in tonsillar and pharyngeal cancers

1993 • 16 citations