Functional evaluation of tumor-infiltrating mononuclear cells. Detection of endogenous interferon-γ and tumor necrosis factor-α in human colorectal adenocarcinomas

Observations on the Systemic Administration of Autologous Lymphokine-Activated Killer Cells and Recombinant Interleukin-2 to Patients with Metastatic Cancer

1985 • 2,616 citations

A New Approach to the Adoptive Immunotherapy of Cancer with Tumor-Infiltrating Lymphocytes

1986 • 1,787 citations

Cachectin/tumor necrosis factor stimulates collagenase and prostaglandin E2 production by human synovial cells and dermal fibroblasts.

1985 • 1,240 citations

Macrophage-induced angiogenesis is mediated by tumour necrosis factor-α

1987 • 1,210 citations

Activation of human polymorphonuclear neutrophil functions by interferon-gamma and tumor necrosis factors.

1985 • 922 citations

Tumor necrosis factor type alpha, a potent inhibitor of endothelial cell growth in vitro, is angiogenic in vivo.

1987 • 718 citations

Effect of interleukin 2, interferon-gamma, and mitogens on the production of tumor necrosis factors alpha and beta.

1985 • 492 citations

Expansion of human tumor infiltrating lymphocytes for use in immunotherapy trials

1987 • 361 citations

Tumor necrosis factor-alpha enhances cytolytic activity of human natural killer cells.

1987 • 235 citations

Functional analysis of mononuclear cells infiltrating into tumors: lysis of autologous human tumor cells by cultured infiltrating lymphocytes.

1987 • 173 citations

Suppressor cell activity of lymphocytes infiltrating human lung and breast tumours

1979 • 131 citations

Depression of natural killer cytotoxic activity in lymphocytes infiltrating human pulmonary tumors.

1985 • 129 citations

The determination of an immunologically active dose of interferon-gamma in patients with melanoma.

1988 • 123 citations

Human tumor infiltrating lymphocytes. Analysis of lymphokine mRNA expression and relevance to cancer immunotherapy.

1989 • 111 citations

Macrophage infiltration of breast tumours: a prospective study.

1977 • 110 citations

Immunohistochemical demonstration of cytoplasmic and membrane-associated tumor necrosis factor in murine macrophages.

1988 • 101 citations

Detection and Quantitation of Macrophage Infiltration Into Primary Human Tumors With the Use of Cell-Surface Markers 2

1977 • 96 citations

Regulation of tumor necrosis factor gene expression in colorectal adenocarcinoma: in vivo analysis by in situ hybridization.

1989 • 90 citations

Tissue T and B cell infiltration of primary and metastatic cancer.

1976 • 82 citations

Effects of interferon-γ on the activation of human T lymphocytes

1988 • 82 citations

Cytological and functional analysis of inflammatory infiltrates in human malignant tumors II. Functional investigations of the infiltrating inflammatory cells

1978 • 79 citations

Colonic carcinoma.A quantitative assessment of lymphocyte infiltration at the periphery of colonic tumors related to prognosis

1978 • 78 citations

Antitumor effect of tumor necrosis factor against various primarily cultured human cancer cells.

1985 • 77 citations

Biological effects of γ‐interferon on human tumor cells: Quantity and affinity of cell membrane receptors for γ‐IFN in relation to growth inhibition and induction of HLA‐DR expression

1985 • 71 citations

Immunology of Tumor Infiltrating Lymphocytes

1985 • 70 citations

Phase I trial of recombinant human gamma-interferon and recombinant human tumor necrosis factor in patients with advanced gastrointestinal cancer.

1989 • 67 citations

A phase I trial of intraperitoneal recombinant gamma-interferon in advanced ovarian carcinoma.

1988 • 58 citations

Content and distribution of macrophages and lymphocytes in solid malignant human tumours

1979 • 56 citations

Cytological and functional analysis of inflammatory infiltrates in human malignant tumors

1980 • 49 citations

Production of human immune interferon (Hu IFN‐γ) studied at the single cell level. Origin, evidence for spontaneous secretion and effect of cyclosporin A

1983 • 49 citations

Characterization of T-lymphocyte subpopulations infiltrating primary breast cancer

1989 • 44 citations

Lymphocyte Subpopulations and T-Cell Subsets in Human Oral Cancer Tissues: Immunohistologic Analysis by Monoclonal Antibodies

1984 • 44 citations

Phase II study of recombinant human interferon gamma (S-6810) on renal cell carcinoma. Summary of two collaborative studies

1987 • 35 citations

Anti-tumor activity of recombinant tumor necrosis factor on mouse fibrosarcoma in vivo and in vitro.

1988 • 32 citations

T-lymphocytes and macrophages in primary murine fibrosarcomas at different stages in their progression.

1978 • 28 citations

Correlation of regional lymph node in vitro antitumor immunoreactivity histology with colorectal carcinoma.

1976 • 27 citations

The analysis of mononuclear cell infiltrations in colorectal adenocarcinoma

1985 • 25 citations

Impaired local natural killer cell activity in human colorectal carcinomas

1989 • 21 citations

The cellular response to human colonic neoplasms: Macrophage numbers

1983 • 19 citations

Lymphoreticular cells within primary colorectal carcinoma: A surface marker study

1981 • 9 citations

Cytotoxicity of lymphocytes from blood, tumour and regional lymph nodes against K562 cells and autoplastic colorectal tumour cells

1982 • 8 citations

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