Placental amino acid transport

Physiological actions of taurine

1992 • 2,555 citations

Purification, Characterization, andin vitroDifferentiation of Cytotrophoblasts from Human Term Placentae*

1986 • 1,556 citations

Cloning and expression of a rat brain L-glutamate transporter

1992 • 1,230 citations

Structure, expression, and functional analysis of a Na(+)-dependent glutamate/aspartate transporter from rat brain.

1992 • 1,185 citations

Transport of cationic amino acids by the mouse ecotropic retrovirus receptor

1991 • 552 citations

Transfer across the perfused human placenta of antipyrine, sodium, and leucine

1972 • 453 citations

Extent of Nicotine and Cotinine Transfer to the Human Fetus, Placenta and Amniotic Fluid of Smoking Mothers

1985 • 426 citations

Cloning and expression of a human neutral amino acid transporter with structural similarity to the glutamate transporter gene family

1993 • 387 citations

Intestinal Transport of Amino Acids and Sugars: Advances Using Membrane Vesicles

1984 • 345 citations

A Distinct Na+-requiring Transport System for Alanine, Serine, Cysteine, and Similar Amino Acids

1967 • 326 citations

Organic ion transport during seven decades the amino acids

1984 • 284 citations

Umbilical uptake of amino acids in the unstressed fetal lamb.

1976 • 266 citations

Cloning and expression of a high affinity taurine transporter from rat brain.

1992 • 261 citations

Preparation of human placental villous surface membrane

1974 • 250 citations

The Use of N-Methylation to Direct the Route of Mediated Transport of Amino Acids

1965 • 248 citations

Amino Acid (System A) Transporter Activity in Microvillous Membrane Vesicles from the Placentas of Appropriate and Small for Gestational Age Babies

1993 • 245 citations

Functional characterization and chromosomal localization of a cloned taurine transporter from human placenta

1994 • 205 citations

The placenta and fetal membranes

1960 • 171 citations

Identification of a new transport system (y+L) in human erythrocytes that recognizes lysine and leucine with high affinity.

1992 • 170 citations

Tissue concentrations of free amino acids in term human placentas

1978 • 145 citations

Simultaneous preparation of paired, syncytial, microvillous and basal membranes from human placenta

1990 • 139 citations

Placental toxicology: tobacco smoke, abused drugs, multiple chemical interactions, and placental function

1991 • 138 citations

Placental Amino Acid Uptake in Normal and Complicated Pregnancies

1988 • 136 citations

Cloning and expression of a mammalian Na+/amino acid cotransporter with sequence similarity to Na+/glucose cotransporters.

1993 • 136 citations

Isolation and partial characterization of the basal cell membrane of human placental trophoblast

1983 • 133 citations

Cloning of the human taurine transporter and characterization of taurine uptake in thyroid cells

1993 • 133 citations

Placental amino acid uptake. III. Transport systems for neutral amino acids

1976 • 130 citations

Neutral amino acid transport systems of microvillous membrane of human placenta

1988 • 130 citations

An improved method for the preparation of human placental syncytiotrophoblast microvilli

1980 • 121 citations

Nutrient Transport Pathways Across the Epithelium of the Placenta

1992 • 120 citations

Anionic amino acid uptake by microvillous membrane vesicles from human placenta

1989 • 118 citations

Placental amino acid uptake: tissue preparation, kinetics, and preincubation effect

1973 • 114 citations

Risks associated with cocaine use during pregnancy.

1992 • 113 citations

Amino acid transport by the cultured human placental trophoblast: effect of insulin on AIB transport

1992 • 110 citations

Alanine transport systems in isolated basal plasma membrane of human placenta

1989 • 110 citations

MATERNAL AND FETAL PLASMA AMINO ACID CONCENTRATIONS DURING GESTATION AND IN RETARDED FETAL GROWTH

1969 • 106 citations

Altered activity of the system A amino acid transporter in microvillous membrane vesicles from placentas of macrosomic babies born to diabetic women.

1994 • 105 citations

N‐ethylmaleimide discriminates between two lysine transport systems in human erythrocytes.

1993 • 98 citations

Transfer of Amino Acids across the In Vitro Perfused Human Placenta

1979 • 95 citations

Extracellular transport pathways in the haemochorial placenta

1989 • 93 citations

Transport of taurine and its regulation by protein kinase C in the JAR human placental choriocarcinoma cell line

1991 • 92 citations

A comparison of amino acid arteriovenous differences across the liver and placenta of the fetal lamb

1989 • 81 citations

Placental Transfer of Glucose and Amino Acids in Intrauterine Growth Retardation: Studies with Substrate Analogs in the Awake Guinea Pig

1990 • 78 citations

Modes of Mediated Exodus of Amino Acids from the Ehrlich Ascites Tumor Cell

1968 • 77 citations

Characterization of tryptophan transport in human placental brush-border membrane vesicles

1986 • 76 citations

Placental ratio in white and black women: Relation to smoking and anemia

1976 • 76 citations

Membrane potential dependence of the kinetics of cationic amino acid transport systems in human placenta.

1994 • 73 citations

Anionic amino acid transport systems in isolated basal plasma membrane of human placenta

1990 • 72 citations

Fetal amino acids in normal pregnancies and in pregnancies complicated by intrauterine growth retardation

1992 • 71 citations

Placental transfer of glutamate and its metabolites in the primate

1975 • 70 citations

TRANSFER OF GLUTAMIC ACID ACROSS THE HUMAN PLACENTA PERFUSED IN VITRO

1979 • 69 citations

Macrosomia in Infants of Insulin-Dependent Diabetic Mothers

1989 • 69 citations

Na⁺ + Cl⁻‐gradient‐driven, high‐affinity, uphill transport of taurine in human placental brush‐border membrane vesicles

1988 • 67 citations

Paracellular permeability pathways in the human placenta: A quantitative and morphological study of maternal-fetal transfer of horseradish peroxidase

1993 • 67 citations

Characterization of amino acid transport systems in human placental brush-border membrane vesicles

1987 • 66 citations

Glutamate metabolism in fetus and placenta of late-gestation sheep

1994 • 66 citations

Regulation of taurine transport in human colon carcinoma cell lines (HT-29 and Caco-2) by protein kinase C

1993 • 65 citations

Inhibition of placental valine uptake after acute and chronic maternal ethanol consumption.

1981 • 64 citations

Cloning and characterization of a glutamate transporter cDNA from human cerebellum

1993 • 64 citations

Two cationic amino acid transport systems in human placental basal plasma membranes

1991 • 63 citations

Effect of ethanol feeding during pregnancy on placental transfer of alpha-aminoisobutyric acid in the rat

1981 • 62 citations

Endogenous amino acid transport systems and expression of mammalian amino acid transport proteins in Xenopus oocytes

1993 • 61 citations

ASC system activity is altered by development of cell polarity in trophoblast from human placenta

1993 • 60 citations

Metabolism and Transport of Maternal Serine by the Ovine Placenta: Glycine Production and Absence of Serine Transport into the Fetus

1993 • 58 citations

Placental Amino Acid Uptake. II. Tissue Preincubation, Fluid Distribution, and Mechanisms of Regulation

1974 • 55 citations

Lysine uptake by human placental microvillous membrane: comparison of system y+ with basal membrane

1995 • 49 citations

Changes in the activities of amino acid transport systems b0,+ and L during development of preimplantation mouse conceptuses

1990 • 49 citations

Characteristics of Histidine Uptake by Human Placental Microvillous Membrane Vesicles

1989 • 48 citations

The influence of cholinergic blockade on the uptake of α-aminoisobutyric acid by isolated human placental villi

1978 • 46 citations

Placental Transfer of Analogs of Glucose and Amino Acids in Experimental Intrauterine Growth Retardation

1979 • 46 citations

Dipeptide transport in brush-border membrane vesicles isolated from normal term human placenta

1985 • 46 citations

Selective fetal malnutrition: The effect of ethanol and acetaldehyde upon uptake of alpha amino isobutyric acid by human placenta

1981 • 45 citations

Amino Acid Pools in the Feto-Maternal System

1976 • 45 citations

Methods for distinguishing amino acid transport systems of a given cell or tissue.

1966 • 44 citations

Characterization of amino acid transport systems in human placental basal membrane vesicles

1990 • 43 citations

THE INFLUENCE OF PRE‐ECLAMPSIA AND DIABETES MELLITUS ON PLASMA FREE AMINO ACIDS IN MATERNAL, UMBILICAL VEIN AND INFANT BLOOD

1971 • 40 citations

Asymmetrical transfer of α-aminoisobutyric acid (AIB), leucine and lysine across the in vitro perfused human placenta

1987 • 39 citations

Uterine uptake of amino acids and placental glutamine--glutamate balance in the pregnant ewe.

1979 • 39 citations

Transport specificity for neutral and basic amino acids at maternal and fetal interfaces of the guinea‐pig placenta

1982 • 38 citations

The human cationic amino acid transporter (ATRC1): Physical and genetic mapping to 13q12–q14

1992 • 38 citations

Characterization of a cocaine binding protein in human placenta

1990 • 37 citations

Selective Fetal Malnutrition: the Effect of in Vivo Ethanol Exposure upon in Vitro Placental Uptake of Amino Acids in the Non-Human Primate

1983 • 37 citations

Effect of ethanol upon placental uptake of amino acids.

1981 • 37 citations

Modulation of the activity of amino acid transport system L by phorbol esters and calmodulin antagonists in a human placental choriocarcinoma cell line

1992 • 36 citations

The relationship between placental protein synthesis and transfer of amino acids

1983 • 36 citations

Functional characterization of l-alanine transport in a placental choriocarcinoma cell line (BeWo)

1994 • 35 citations

Depression of Amino Acid Uptake in Human Placental Villus by Cocaine, Morphine and Nicotine

1984 • 35 citations

Short-term and long-term ethanol administration inhibits the placental uptake and transport of valine in rats.

1981 • 35 citations

Epidermal Growth Factor and Insulin-like Growth Factor I Differently Influence the Directional Accumulation and Transfer of 2-Aminoisobutyrate (AIB) by Human Placental Trophoblast in Two-Sided Culture

1994 • 34 citations

Maternal tobacco smoking and changes in amino acid uptake by human placental villi: Induction of uptake systems, gammaglutamyltranspeptidase and membrane fluidity

1989 • 31 citations

Plasma Amino Acids in Diabetic Pregnant Rats and in Their Fetal and Adult Offspring

1989 • 31 citations

Selective Impairment of Taurine Transport by Cyclosporin A in a Human Placental Cell Line

1992 • 29 citations

Effect of Ethanol on Human Placental Transport of Model Amino Acids and Glucose

1989 • 29 citations

Human placental L‐tyrosine transport: a comparison of brush‐border and basal membrane vesicles.

1990 • 28 citations

Relationship between thyroid hormone transport and neutral amino acid transport in JAR human choriocarcinoma cells.

1994 • 27 citations

Pentose phosphate pathway in cellular trophoblasts from full-term human placentas

1991 • 27 citations

Glycine uptake by microvillous and basal plasma membrane vesicles from term human placentae

1993 • 27 citations

Lysine and alanine transport in the perfused guinea-pig placenta

1989 • 27 citations

Cocaine inhibits alanine uptake by human placental microvillous membrane vesicles

1993 • 26 citations

Taurine Transport in the in Vitro Perfused Human Placenta

1990 • 26 citations

FETO‐MATERNAL AMINO ACID METABOLISM

1974 • 25 citations

Amino acid carriers at maternal and fetal surfaces of the placenta by single circulation paired-tracer dilution. Kinetics of phenylalanine transport

1980 • 25 citations

Effects of nicotine and nicotine/ethanol on human placental amino acids transfer

1989 • 24 citations

Ultrastructural evidence for transtrophoblastic channels in the hemomonochorial placenta of the degu (Octodon degus)

1992 • 22 citations

Alanine umbilical uptake, disposal rate, and decarboxylation rate in the fetal lamb

1993 • 21 citations

Glutamate oxidation by trophoblasts in vitro

1994 • 20 citations

Calmodulin-dependent modulation of pH sensitivity of the amino acid transport system L in human placental choriocarcinoma cells

1994 • 20 citations

Solubilization and functional reconstitution of the human placental taurine transporter

1993 • 18 citations

Asymmetrical transfer of inert hydrophilic solutes across rat placenta

1993 • 17 citations

Stimulation of taurine efflux from human placental tissue by a hypoosmotic challenge

1993 • 17 citations

The comparative physiology of fetal nutrition

1984 • 15 citations

Diagnosis and management of fetal growth retardation.

1990 • 15 citations

Inactivation of taurine transporter by calcium in purified human placental brush border membrane vesicles

1991 • 14 citations

Is there control of solute transport at placental level?

1988 • 11 citations