Arsenic co-exposure potentiates benzo[a]pyrene genotoxicity

Methylation-Induced Repression— Belts, Braces, and Chromatin

1999 • 1,823 citations

Substrate-inducible Microsomal Aryl Hydroxylase in Mammalian Cell Culture

1968 • 1,691 citations

Nuclease P1-mediated enhancement of sensitivity of ³²P-Postlabeling test for structurally diverse DNA adducts

1986 • 1,009 citations

DNA methylation: past, present and future directions

2000 • 609 citations

Arsenic: health effects, mechanisms of actions, and research issues.

1999 • 604 citations

Association of arsenic-induced malignant transformation with DNA hypomethylation and aberrant gene expression

1997 • 554 citations

Chemoprotection against cancer by Phase 2 enzyme induction

1995 • 454 citations

Dihydrodiol Dehydrogenases and Polycyclic Aromatic Hydrocarbon Activation: Generation of Reactive and Redox Active o-Quinones

1998 • 448 citations

Chemical and molecular regulation of enzymes that detoxify carcinogens.

1993 • 426 citations

Ingested Arsenic and Internal Cancer: A Historical Cohort Study Followed for 33 Years

1995 • 313 citations

Arsenic alters cytosine methylation patterns of the promoter of the tumor suppressor gene p53 in human lung cells: a model for a mechanism of carcinogenesis

1997 • 306 citations

Determining Glutathione and Glutathione Disulfide Using the Fluorescence Probe o-Phthalaldehyde

2000 • 289 citations

Long-Term Mortality Study of Steelworkers

1971 • 261 citations

Electrophile and antioxidant regulation of enzymes that detoxify carcinogens.

1995 • 230 citations

NAD(P)H:quinone oxidoreductase1 (DT diaphorase) specifically prevents the formation of benzo[a]pyrene quinone-DNA adducts generated by cytochrome P4501A1 and P450 reductase.

1994 • 193 citations

Cysteine Metabolism and Metal Toxicity

2011 • 185 citations

Arsenic toxicity is enzyme specific and its affects on ligation are not caused by the direct inhibition of DNA repair enzymes

1998 • 184 citations

Interaction of arsenic(III) with nucleotide excision repair in UV- irradiated human fibroblasts

1997 • 178 citations

Arsenic Exposure, Smoking, and Respiratory Cancer in Copper Smelter Workers

1982 • 149 citations

CANCER EXPERIENCE AMONG COKE BY‐PRODUCT WORKERS

1976 • 138 citations

Synthesis and Characterization of Polycyclic Aromatic Hydrocarbon o-Quinone Depurinating N7-Guanine Adducts

1999 • 132 citations

Glutathione peroxidase and catalase modulate the genotoxicity of arsenite

1997 • 132 citations

High benzo[a]pyrene diol-epoxide DNA adduct levels in lung and blood cells from individuals with combined CYP1A1 MspI/Msp-GSTM1*0/*0 genotypes.

1998 • 132 citations

Arsenic trioxide sensitivity is associated with low level of glutathione in cancer cells

1999 • 131 citations

Effect of Metals on Polycyclic Aromatic Hydrocarbon Induction of CYP1A1 and CYP1A2 in Human Hepatocyte Cultures

2001 • 129 citations

Mutations affecting the regulation of transcription of the cytochrome P1-450 gene in the mouse Hepa-1 cell line.

1985 • 124 citations

Arsenite retards DNA break rejoining by inhibiting DNA ligation

1997 • 119 citations

Reactivity of benzo[a]pyrene-7,8-dione with DNA. Evidence for the formation of deoxyguanosine adducts

1993 • 115 citations

On the interaction between occupational arsenic exposure and smoking and its relationship to lung cancer.

1981 • 114 citations

Carcinomas of the respiratory tract in hamsters given arsenic trioxide and/or benzo[a]pyrene by the pulmonary route

1984 • 114 citations

Synergism between Occupational Arsenic Exposure and Smoking in the Induction of Lung Cancer

1992 • 113 citations

Arsenic Exposure, Smoking, and Lung Cancer in Smelter Workers—A Case-Control Study

1991 • 112 citations

High benzo[a]pyrene diol-epoxide DNA adduct levels in lung and blood cells from individuals with combined CYP1A1 MspI/MspI-GSTM1*0/*0 genotypes

1998 • 112 citations

Mechanism of comutagenesis of sodium arsenite withn-methyl-n-nitrosourea

1989 • 111 citations

Effect of arsenic and cadmium on the persistence of mutagen-induced DNA lesions in human cells

1996 • 97 citations

Impact of inherited polymorphisms in glutathione S-transferase M1, microsomal epoxide hydrolase, cytochrome P450 enzymes on DNA, and blood protein adducts of benzo(a)pyrene-diolepoxide.

1998 • 89 citations

Effect of Glutathione Depletion and Metallothionein Gene Expression on Arsenic-Induced Cytotoxicity and c-mycExpressionin Vitro

1998 • 88 citations

Aromatic DNA adducts in foundry workers in relation to exposure, life style and CYP1A1 and glutathione transferase M1 genotype

1997 • 84 citations

Relation of arsenic exposure to lung cancer among tin miners in Yunnan Province, China.

1989 • 82 citations

Arsenic Disrupts Cellular Levels of p53 and mdm2: A Potential Mechanism of Carcinogenesis

1999 • 81 citations

Pathways involved in the metabolism and activation of polycyclic hydrocarbons

1986 • 78 citations

Observations on the dose-response curve for arsenic exposure and lung cancer.

1993 • 77 citations

Binding of benzo[a]pyrene to DNA by cytochrome P 450 catalyzed one-electron oxidation in rat liver microsomes and nuclei

1990 • 74 citations

Detection and characterization of carcinogen—DNA adducts in exfoliated urothelial cells from 4-aminobiphenyl-treated dogs by ³²P-postlabelling and subsequent thin-layer and high-pressure liquid chromatography

1990 • 71 citations

Comutagenesis of sodium arsenite with ultraviolet radiation in Chinese hamster V79 cells

1991 • 71 citations

An Epidemiological Study of Exposure to Coal Tar Pitch Volatiles Among Coke Oven Workers

1975 • 70 citations

Analysis of two benzo[a]pyrene-resistant mutants of the mouse hepatoma Hepa-1 P(1)450 gene via cDNA expression in yeast.

1987 • 68 citations

Glutathione as a cellular defence against arsenite toxicity in cultured Chinese hamster ovary cells

1993 • 67 citations

Disruption of dioxin-inducible phase I and phase II gene expression patterns by cadmium, chromium, and arsenic

2000 • 62 citations

Neutrophils amplify the formation of DNA adducts by benzo[a]pyrene in lung target cells.

1997 • 61 citations

Expression of p53 in Arsenic-Related and Sporadic Basal Cell Carcinoma

2000 • 60 citations

Overexpression of Stably Transfected Human GlutathioneS-Transferase P1–1 Protects against DNA Damage by Benzo[a]pyrene Diol-Epoxide in Human T47D Cells

1998 • 55 citations

Evidence that benzo(a)pyrene-resistant, aryl hydrocarbon hydroxylase-deficient variants of mouse hepatoma line, Hepa-1, are mutational in origin

1981 • 52 citations

Preliminary experimental study on carcinogenicity of arsenic trioxide in rat lung.

1977 • 51 citations

A retrospective epidemiological study of morbidity at a large western copper smelter

1979 • 50 citations

Arsenite enhances DNA double-strand breaks and cell killing of methyl methanesulfonate-treated cells by inhibiting the excision of alkali-labile sites

1993 • 49 citations

Chronic, topical exposure to benzo[a]pyrene induces relatively high steady-state levels of DNA adducts in target tissues and alters kinetics of adduct loss.

1996 • 47 citations

Use of UvrABC nuclease to quantify benzo[a]pyrene diol epoxideDNA adduct formation at methylated versus unmethylated CpG sites in the p53 gene

1999 • 47 citations

Study of arsenic mutagenesis using the plasmid shuttle vector pZ189 propagated in DNA repair proficient human cells

1997 • 46 citations

Effect of Arsenite on Induction of CYP1A and CYP2H in Primary Cultures of Chick Hepatocytes

1998 • 34 citations

Stable Expression of MouseCyplaland HumanCYP1A2cDNAs Transfected into Mouse Hepatoma Cells Lacking Detectable P450 Enzyme Activity

1990 • 31 citations

Thiol involvement in the inhibition of DNA repair by metals in mammalian cells.

1989 • 24 citations

Identification of benzo[a]pyrene-7,8-dione as an authentic metabolite of (±)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene in isolated rat hepatocytes

1995 • 23 citations

Benzo[a]pyrene coated ferric oxide and aluminum oxide particles: uptake, metabolism and DNA binding in hamster pulmonary alveolar macrophages and tracheal epithelial cells in vitro [published erratum appears in Carcinogenesis 1997 May;18(5):1123]

1997 • 22 citations

Effects of arsenite treatment on NAD(P)H:quinone acceptor oxidoreductase activity in liver, lung, kidney, and heart of the rat. Comparison to induction by the polyaromatic hydrocarbon, beta-naphthoflavone.

1993 • 11 citations