Expression of Peroxisome Proliferator-Activated Receptor α (PPARα) in Primary Cultures of Human Vascular Endothelial Cells

Culture of Human Endothelial Cells Derived from Umbilical Veins. IDENTIFICATION BY MORPHOLOGIC AND IMMUNOLOGIC CRITERIA

1973 • 6,904 citations

Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction

1989 • 3,557 citations

Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators

1990 • 3,462 citations

Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ

1997 • 2,105 citations

The PPARα–leukotriene B4 pathway to inflammation control

1996 • 1,328 citations

Inhibition of Adipogenesis Through MAP Kinase-Mediated Phosphorylation of PPARγ

1996 • 1,033 citations

Elevated circulating free fatty acid levels impair endothelium-dependent vasodilation.

1997 • 756 citations

Copper,zinc superoxide dismutase is primarily a cytosolic protein in human cells.

1992 • 492 citations

Alterations in Lipoprotein Metabolism in Peroxisome Proliferator-activated Receptor α-deficient Mice

1997 • 419 citations

Fibrates increase human apolipoprotein A-II expression through activation of the peroxisome proliferator-activated receptor.

1995 • 398 citations

Peroxisome proliferator-activated receptor mediates induction of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene by fatty acids.

1994 • 380 citations

Mode of Action of Peroxisome Proliferators as Hypolipidemic Drugs.

1995 • 342 citations

High Glucose Induces Antioxidant Enzymes in Human Endothelial Cells in Culture: Evidence Linking Hyperglycemia and Oxidative Stress

1996 • 312 citations

Insulin- and Mitogen-activated Protein Kinase-mediated Phosphorylation and Activation of Peroxisome Proliferator-activated Receptor γ

1996 • 272 citations

Negative regulation of the human apolipoprotein A-I promoter by fibrates can be attenuated by the interaction of the peroxisome proliferator-activated receptor with its response element.

1994 • 246 citations

Oleic Acid Inhibits Endothelial Nitric Oxide Synthase by a Protein Kinase C–Independent Mechanism

1995 • 212 citations

The peroxisome proliferator-activated receptor alpha is a phosphoprotein: regulation by insulin.

1996 • 179 citations

PPAR Tissue Distribution and Interactions with Other Hormone‐Signaling Pathways^a

1996 • 156 citations

Eicosapentaenoic Acid Enhances Nitric Oxide Production by Cultured Human Endothelial Cells

1997 • 145 citations

Dexamethasone and Insulin Demonstrate Marked and Opposite Regulation of the Steady‐State mRNA Level of the Peroxisomal Proliferator‐Activated Receptor (PPAR) in Hepatic Cells

1994 • 143 citations

Induction of the peroxisome proliferator activated receptor by fenofibrate in rat liver

1992 • 110 citations

"Normal" Umbilical Arterial and Venous Acid-Base and Blood Gas Values

1993 • 74 citations

Differential induction of VCAM-1 on human iliac venous and arterial endothelial cells and its role in adhesion.

1993 • 72 citations

The Peroxisome Proliferator-Activated Receptor α (PPARα) Regulates the Plasma Thiobarbituric Acid-Reactive Substance (TBARS) Level

1997 • 34 citations

Studies on the Mechanism of Fibrate-Inhibited Expression of Plasminogen Activator Inhibitor-1 in Cultured Hepatocytes From Cynomolgus Monkey

1997 • 23 citations