Peroxynitrite, the Breakdown Product of Nitric Oxide, Is Beneficial in Blood Cardioplegia but Injurious in Crystalloid Cardioplegia

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

1990 • 7,068 citations

Peroxynitrite-induced membrane lipid peroxidation: The cytotoxic potential of superoxide and nitric oxide

1991 • 2,215 citations

Myeloperoxidase activity as a quantitative assessment of neutrophil infiltration into ischemie myocardium

1985 • 994 citations

Oxidative Damage and Tyrosine Nitration from Peroxynitrite

1996 • 990 citations

Endogenous nitric oxide: physiology, pathology and clinical relevance

1991 • 766 citations

Nitric oxide synthase generates superoxide and nitric oxide in arginine-depleted cells leading to peroxynitrite-mediated cellular injury.

1996 • 730 citations

Control of coronary vascular tone by nitric oxide.

1990 • 713 citations

Generation of peroxynitrite contributes to ischemia-reperfusion injury in isolated rat hearts

1997 • 339 citations

Peroxynitrite inhibits leukocyte-endothelial cell interactions and protects against ischemia-reperfusion injury in rats.

1997 • 270 citations

Peroxynitrite-induced Accumulation of Cyclic GMP in Endothelial Cells and Stimulation of Purified Soluble Guanylyl Cyclase

1995 • 199 citations

The use of left ventricular end-ejection pressure and peak pressure in the estimation of the end-systolic pressure-volume relationship.

1984 • 195 citations

Involvement of nitric oxide and nitrosothiols in relaxation of pulmonary arteries to peroxynitrite

1994 • 180 citations

Nitric Oxide Attenuates Neutrophil-Mediated Myocardial Contractile Dysfunction After Ischemia and Reperfusion

1996 • 143 citations

Asbestos inhalation induces reactive nitrogen species and nitrotyrosine formation in the lungs and pleura of the rat.

1998 • 118 citations

Supplemental l-arginine during cardioplegic arrest and reperfusion avoids regional postischemic injury

1995 • 108 citations

Mechanisms of cardioprotection by peroxynitrite in myocardial ischemia and reperfusion injury

1998 • 107 citations

Peroxynitrite aggravates myocardial reperfusion injury in the isolated perfused rat heart

1997 • 80 citations

Endothelial and Myocardial Cell Protection by a Cysteine-Containing Nitric Oxide Donor After Myocardial Ischemia and Reperfusion

1993 • 63 citations

Coronary artery endothelial dysfunction after global ischemia, blood cardioplegia, and reperfusion

1994 • 58 citations

Peroxynitrite, the product of nitric oxide and superoxide, causes myocardial injury in the isolated perfused rat heart

1997 • 54 citations

NO elicits prolonged relaxation of bovine pulmonary arteries via endogenous peroxynitrite generation

1997 • 50 citations

Effect of peroxynitrite on plasma extravasation, microvascular blood flow and nociception in the rat

1997 • 44 citations

A protective role of nitric oxide in isolated ischaemic/reperfused rat heart

1995 • 37 citations

Critical timing of nitric oxide supplementation in cardioplegic arrest and reperfusion.

1996 • 36 citations

Nitrogen dioxide causes pulmonary arterial relaxation via thiol nitrosation and NO formation

1996 • 35 citations

Surgical Revascularization of Acute (1 Hour) Coronary Occlusion: Blood versus Crystalloid Cardioplegia

1986 • 22 citations

Crystalloid versus blood cardioplegia in coronary by-pass surgery. A prospective, randomized, controlled study in 100 consecutive adults.

1994 • 11 citations

Evaluation of a new generation cardioplegia administration system.

1997 • 10 citations