The role of metabolic activation by cytochrome P-450 in covalent binding of VP 16-213 to rat liver and HeLa cell microsomal proteins

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

The colorimetric estimation of formaldehyde by means of the Hantzsch reaction

1953 • 4,357 citations

A perspective on the role of chemically reactive metabolites of foreign compounds in toxicity—I correlation of changes in covalent binding of reactivity metabolites with changes in the incidence and severity of toxicity

1974 • 225 citations

DNA damage as a basis for 4'-demethylepipodophyllotoxin-9-(4,6-O-ethylidene-beta-D-glucopyranoside) (etoposide) cytotoxicity.

1983 • 223 citations

Effect of VP-16-213 on the intracellular degradation of DNA in HeLa cells

1976 • 197 citations

Introduction to Biochemical Toxicology

1981 • 183 citations

The Spectrophotometric Measurement of Turbid Suspensions of Cytochromes Associated with Drug Metabolism

1972 • 160 citations

Spin-trapping of the trichloromethyl radical produced during enzymic NADPH oxidation in the presence of carbon tetrachloride or bromotrichloromethane

1978 • 155 citations

The podophyllotoxin derivatives VP16-213 and VM26

1982 • 146 citations

A perspective on the role of chemically reactive metabolites of foreign compounds in toxicity—II. Alterations in the kinetics of covalent binding

1974 • 107 citations

The metabolism of 3,5-di-tert.-butyl-4-hydroxytoluene in the rat and in man

1968 • 80 citations

Structure-activity relations for methylenedioxyphenyl and related compounds on hepatic microsomal enzyme function, as measured by prolongation of hexobarbital narcosis and zoxazolamine paralysis in mice

1970 • 50 citations

Free radical metabolism of VP-16 and inhibition of anthracycline-induced lipid peroxidation

1983 • 47 citations

Biological fate of butylated hydroxytoluene (BHT); Binding in vitro of BHT to liver microsomes.

1979 • 43 citations

On the mechanism of covalent binding of butylated hydroxytoluene to microsomal protein

1983 • 36 citations

In vitro and in vivo metabolism of VP 16–213 in the rat

1982 • 17 citations

5-Fluoro- and 5-chlorocyclophosphamide: synthesis, metabolism, and antitumor activity of the cis and trans isomers

1981 • 16 citations

Combined effects of low doses of DDT and phenobarbital on cytochrome P450 and amidopyrine demethylation

1977 • 14 citations

Deleted Work

1955 • 0 citations