Testing the rate-of-living/oxidative damage theory of aging in the nematode model Caenorhabditis elegans

Aging: A Theory Based on Free Radical and Radiation Chemistry

1956 • 8,252 citations

A C. elegans mutant that lives twice as long as wild type

1993 • 3,250 citations

Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans

2003 • 2,209 citations

daf-2 , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegans

1997 • 2,174 citations

IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice

2002 • 2,057 citations

Extension of Life-Span by Loss of CHICO, a Drosophila Insulin Receptor Substrate Protein

2001 • 1,398 citations

Autophagy Genes Are Essential for Dauer Development and Life-Span Extension in C. elegans

2003 • 1,214 citations

Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans

2002 • 1,150 citations

Mitochondrial superoxide: production, biological effects, and activation of uncoupling proteins

2004 • 1,019 citations

A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility.

1988 • 958 citations

Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans

2006 • 856 citations

Genetic Analysis of Tissue Aging in Caenorhabditis elegans: A Role for Heat-Shock Factor and Bacterial Proliferation

2002 • 774 citations

Uncoupled and surviving: individual mice with high metabolism have greater mitochondrial uncoupling and live longer

2004 • 748 citations

Two Pleiotropic Classes of daf-2 Mutation Affect Larval Arrest, Adult Behavior, Reproduction and Longevity in Caenorhabditis elegans

1998 • 691 citations

The Rate of Living.

1928 • 686 citations

Mitochondrial Electron Transport Is a Key Determinant of Life Span in Caenorhabditis elegans

2001 • 619 citations

Increased Life-Span of age -1 Mutants in Caenorhabditis elegans and Lower Gompertz Rate of Aging

1990 • 402 citations

Multiple Stressors in Caenorhabditis elegans Induce Stress Hormesis and Extended Longevity

2002 • 331 citations

ON THE INFLUENCE OF FOOD AND TEMPERATURE UPON THE DURATION OF LIFE

1917 • 268 citations

Regulation of Hypoxic Death in C. elegans by the Insulin/IGF Receptor Homolog DAF-2

2002 • 246 citations

Analysis of long-lived C. elegans daf-2 mutants using serial analysis of gene expression

2005 • 203 citations

Metabolic rate is not reduced by dietary-restriction or by lowered insulin/IGF-1 signalling and is not correlated with individual lifespan in Drosophila melanogaster

2004 • 144 citations

Diapause-associated metabolic traits reiterated in long-lived daf-2 mutants in the nematode Caenorhabditis elegans

2006 • 125 citations

Age-related changes of mitochondrial structure and function in Caenorhabditis elegans

2006 • 97 citations

Lack of Correlation between Mitochondrial Reactive Oxygen Species Production and Life Span in Drosophila

2004 • 87 citations

Protein Carbonyl Accumulation in Aging Dauer Formation--Defective (daf) Mutants of Caenorhabditis elegans

1999 • 77 citations

Assessing metabolic activity in aging Caenorhabditis elegans: concepts and controversies

2002 • 75 citations

Movement as an Index of Vitality:Comparing Wild Type and the age-1 Mutant of Caenorhabditis elegans

1995 • 72 citations

Longevity and Metabolism in Drosophila melanogaster

2004 • 65 citations

Age-Specific Demographic Profiles of Longevity Mutants in Caenorhabditis elegans Show Segmental Effects

2001 • 57 citations

Protein oxidation during aging of the nematode Caenorhabditis elegans

2002 • 57 citations

Examination of the requirement for ucp-4, a putative homolog of mammalian uncoupling proteins, for stress tolerance and longevity in C. elegans

2005 • 48 citations

Lack of correlation between body mass and metabolic rate in Drosophila melanogaster

2004 • 34 citations

Model systems in aging

2004 • 22 citations

Energy Metabolism and Lifespan Determination

2003 • 13 citations

Energy metabolism, anti-oxidant defense and aging in Caenorhabditis elegans

2003 • 4 citations

Metabolism and life span determination in C. elegans

2003 • 3 citations