Monoclonal antibody characterization of a chymotrypsin-like molecule on neutrophil membrane associated with cellular activation.

Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g.

1968 • 5,084 citations

A MODIFIED SPECTROPHOTOMETRIC DETERMINATION OF CHYMOTRYPSIN, TRYPSIN, AND THROMBIN

1959 • 1,705 citations

The Biochemistry of Memory: A New and Specific Hypothesis

1984 • 1,048 citations

The Complete Primary Structure of Protein Kinase C—the Major Phorbol Ester Receptor

1986 • 878 citations

EVALUATION OF THE TRYPAN BLUE TECHNIQUE FOR DETERMINATION OF CELL VIABILITY

1964 • 718 citations

Human neutrophil Fc gamma receptor distribution and structure.

1982 • 577 citations

The kinetics of antibody binding to membrane antigens in solution and at the cell surface

1980 • 568 citations

Thrombin stimulates the adherence of neutrophils to human endothelial cells in vitro.

1985 • 380 citations

Chemoattractant receptor-induced hydrolysis of phosphatidylinositol 4,5-bisphosphate in human polymorphonuclear leukocyte membranes. Requirement for a guanine nucleotide regulatory protein.

1985 • 358 citations

A MODIFIED SPECTROPHOTOMETRIC DETERMINATION OF CHYMOTRYPSIN, TRYPSIN, AND THROMBIN

1959 • 334 citations

Receptor-Coupled Activation of Phosphoinositide-Specific Phospholipase C by an N Protein

1986 • 324 citations

One-step purification of mouse monoclonal antibodies from ascitic fluid by DEAE Affi-gel blue chromatography

1982 • 322 citations

Definition of a common leukocyte cell-surface antigen (Lp95-150) associated with diverse cell-mediated immune functions.

1983 • 305 citations

Inhibition of phagocytosis of complement C3- or immunoglobulin G-coated particles and of C3bi binding by monoclonal antibodies to a monocyte-granulocyte membrane glycoprotein (Mol).

1983 • 303 citations

THE DETERMINATION OF LYSOZYME

1949 • 290 citations

Release and metabolism of arachidonic acid in human neutrophils.

1981 • 281 citations

Chemoattractants stimulate degradation of methylated phospholipids and release of arachidonic acid in rabbit leukocytes.

1979 • 279 citations

Subcellular localization and heterogeneity of neutral proteases in neutrophilic polymorphonuclear leukocytes.

1975 • 254 citations

Receptor-mediated inhibition of adenylate cyclase and stimulation of arachidonic acid release in 3T3 fibroblasts. Selective susceptibility to islet-activating protein, pertussis toxin.

1985 • 245 citations

Increased levels of cyclic adenosine-3',5'-monophosphate in human polymorphonuclear leukocytes after surface stimulation.

1980 • 193 citations

Pertussis toxin inhibits fMet-Leu-Phe- but not phorbol ester-stimulated changes in rabbit neutrophils: role of G proteins in excitation response coupling.

1985 • 175 citations

A modified procedure for the determination of loukocyte alkaline phosphatase

1970 • 165 citations

Exposure of fibrinogen receptor on human platelets by proteolytic enzymes.

1981 • 164 citations

Association of the N-formyl-Met-Leu-Phe receptor in human neutrophils with a GTP-binding protein sensitive to pertussis toxin.

1985 • 159 citations

Activation of the inhibitory GTP-binding protein of adenylate cyclase, Gi, by beta-adrenergic receptors in reconstituted phospholipid vesicles.

1984 • 158 citations

The inhibition of neutrophil granule enzyme secretion and chemotaxis by pertussis toxin.

1985 • 155 citations

Correlation of human neutrophil secretion, chemoattractant receptor mobilization, and enhanced functional capacity.

1982 • 154 citations

Protease inhibitors antagonize the activation of polymorphonuclear leukocyte oxygen consumption

1979 • 150 citations

Evidence that proteases are involved in superoxide production by human polymorphonuclear leukocytes and monocytes.

1980 • 146 citations

Chemoattractant receptor functions in human polymorphonuclear leukocytes are divergently altered by membrane fluidizers.

1982 • 140 citations

Neutrophil plasma membranes. I. High-yield purification of human neutrophil plasma membrane vesicles by nitrogen cavitation and differential centrifugation.

1980 • 133 citations

Chemoattractant-elicited alterations of cAMP levels in human polymorphonuclear leukocytes require a Ca2+-dependent mechanism which is independent of transmembrane activation of adenylate cyclase.

1985 • 124 citations

Signal transduction and ligand-receptor dynamics in the human neutrophil. Transient responses and occupancy-response relations at the formyl peptide receptor.

1985 • 120 citations

In vitro stimulation of lymphocytes by neutral proteinases from human polymorphonuclear leukocyte granules.

1976 • 111 citations

Isolation and partial characterization of the membrane protein constituents of human neutrophil receptors for chemotactic formylmethionyl peptides

1981 • 81 citations

Role of a peptidase in phagocyte chemotaxis.

1976 • 81 citations

Enhanced release of oxygen metabolites by monocyte-derived macrophages exposed to proteolytic enzymes: activity of neutrophil elastase and cathepsin G.

1984 • 75 citations

Stimulus response coupling in the human neutrophil. Differential requirements for receptor occupancy in neutrophil responses to a chemoattractant.

1984 • 68 citations

Cationic proteins of human granulocytes. IV. Esterase activity.

1975 • 58 citations

PARTIAL BIOCHEMICAL CHARACTERIZATION OF THE ACTIVATED ESTERASE REQUIRED IN THE COMPLEMENT-DEPENDENT CHEMOTAXIS OF RABBIT POLYMORPHONUCLEAR LEUKOCYTES

1967 • 56 citations

Histamine modulates contraction and cyclic nucleotides in cultured rat mesangial cells. Differential effects mediated by histamine H1 and H2 receptors.

1985 • 49 citations

Activation of neutrophils by N-formyl chemotactic peptides.

1984 • 46 citations

Possible involvement of proteases in superoxide production by human polymorphonuclear leukocytes

1979 • 41 citations

Triggering of the macrophage and neutrophil respiratory burst by antibody bound to a spin-label phospholipid hapten in model lipid bilayer membranes

1980 • 40 citations

A rapid isolation procedure of plasma membranes from human neutrophils using self-generating Percoll gradients. Importance of pH in avoiding contamination by intracellular membranes

1985 • 38 citations

The Evidence for the existence of chymotrypsin-like esterase activity in the plasma membranes of rabbit neutrophils and the specific chemotactic peptide binding activity of the subcellular fractions

1978 • 35 citations

A monoclonal antibody-inhibiting FMLP-induced chemotaxis of human neutrophils.

1981 • 30 citations

Inhibition by tosyl-L-phenylalanyl chloromethyl ketone of membrane potential changes in rat neutrophils. Correlation with the inhibition of biological activity.

1983 • 23 citations

Lag period for superoxide anion generation and lysosomal enzyme release from human neutrophils: effects of calcium antagonists and anion channel blockers.

1984 • 21 citations

Inhibition of superoxide production in human neutrophils by purified soybean polypeptides. Re-evaluation of the involvement of proteases.

1983 • 17 citations

Proteolytic activation and solubilization of adenylate and guanylate cyclases

1983 • 11 citations

Modulation of human neutrophil effector functions by monoclonal antibodies against surface membrane molecules of 94,000 and 180,000 molecular weight

1986 • 9 citations

Monoclonal Antibody to Human Granulocytes: Cellular Specificity and Functional Studies

1984 • 5 citations

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