The appearance of new structures and functions in proteins during evolution

Evolution by Gene Duplication

1970 • 6,000 citations

Evolution by gene duplication

1970 • 5,849 citations

Atlas of protein sequence and structure

1965 • 4,462 citations

Repeated Sequences in DNA

1968 • 2,836 citations

Evolutionary Divergence and Convergence in Proteins

1965 • 2,780 citations

Comparative Animal Physiology

1951 • 2,152 citations

Gene Regulation for Higher Cells: A Theory

1969 • 2,022 citations

Non-Darwinian Evolution

1969 • 1,731 citations

Distinguishing Homologous from Analogous Proteins

1970 • 1,512 citations

Chemical and biological evolution of a nucleotide-binding protein

1974 • 1,457 citations

Molecules as documents of evolutionary history

1965 • 1,305 citations

ORIGIN OF EUKARYOTIC CELLS

1971 • 1,213 citations

Handbook of molecular cytology

1969 • 1,011 citations

Chance and Necessity

1970 • 855 citations

Origin of Eukaryotic Cells.

1971 • 734 citations

Structure and function of haemoglobin

1965 • 603 citations

Three abundance classes in HeLa cell messenger RNA

1974 • 563 citations

Comparative Animal Physiology

1961 • 518 citations

Rate of Fixation of Nucleotide Substitutions in Evolution

1969 • 506 citations

On the evolution of the genetic code.

1965 • 486 citations

Protides of Biological Fluids

1971 • 471 citations

Heterochromatin, Satellite DNA, and Cell Function

1971 • 459 citations

Repetitive DNA sequences in Drosophila

1971 • 458 citations

Organization, Transcription, and Regulation in the Animal Genome

1973 • 454 citations

Evolution of the Structure of Ferredoxin Based on Living Relics of Primitive Amino Acid Sequences

1966 • 447 citations

Enzymatic Synthesis of Deoxyribonucleic Acid

1960 • 378 citations

Neighbouring group participation

1964 • 376 citations

Genetic variability maintained in a finite population due to mutational production of neutral and nearly neutral isoalleles

1968 • 364 citations

PSEUDOALLELISM AND GENE EVOLUTION

1951 • 358 citations

Comprehensive Biochemistry

1967 • 343 citations

Vertebrates without Erythrocytes and Blood Pigment

1954 • 342 citations

Mechanisms of antibiotic resistance in bacteria.

1987 • 340 citations

Evolution of higher-organism DNA

1970 • 328 citations

The structure of thermolysin: An electron density map at 2.3 Å resolution

1972 • 315 citations

Chemical Paleogenetics. Molecular "Restoration Studies" of Extinct Forms of Life.

1963 • 297 citations

Gene Evolution and the Hæmoglobins

1961 • 295 citations

The genes for silk fibroin in Bombyx mori

1972 • 288 citations

Reiteration and Clustering of DNA Sequences Complementary to Histone Messenger RNA

1971 • 259 citations

Amino-acid Sequence of Thermolysin

1972 • 251 citations

Protides of the Biological Fluids

1963 • 247 citations

A measurement of the sequence complexity of polysomal messenger RNA in sea urchin embryos

1974 • 246 citations

Duplicate genes for tyrosine transfer RNA in Escherichia coli

1970 • 225 citations

On earlier states of the biochemical system

1974 • 210 citations

Atlas of protein sequence and structure 1969 vol 4

1969 • 197 citations

Comparative Aspects of Bacterial Lipids

1972 • 189 citations

Evolution of Genetic Systems

1973 • 186 citations

CHROMOSOME STRUCTURE

1970 • 183 citations

Mitochondrial nucleic acids in the peptite colonie mutants: Deletions and repetitions of genes

1973 • 179 citations

Fat Metabolism in Higher Plants

1967 • 178 citations

Processes of Organic Evolution

1937 • 171 citations

Molecular Cytogenetics

1973 • 165 citations

Biochemical evolution and the origin of life

1972 • 156 citations

Functional Organization of Genetic Material as a Product of Molecular Evolution

1971 • 155 citations

“Repetitive” DNA in higher organisms

1971 • 150 citations

Topological comparison of adenyl kinase with other proteins

1974 • 144 citations

Study of Microbial Evolution through Loss of Biosynthetic Functions: Establishment of “Defective” Mutants

1967 • 144 citations

Repeated sequences in the DNA of Drosophila and their localization in giant chromosomes

1970 • 144 citations

Genetic information in oocyte RNA

1971 • 143 citations

Molecular biology and the origin of species : heterosis, protein polymorphism and animal breeding

1970 • 133 citations

Electron transport systems of Rhizobium japonicum. II. Rhizobium haemoglobin, cytochromes and oxidases in free-living (cultured) cells

1969 • 133 citations

Phylogeny of Immunoglobulins

1969 • 128 citations

Subtilisin BPN'

1967 • 124 citations

Molecular Anthropology

1976 • 118 citations

How Different are the DNAs from Related Animals?

1968 • 117 citations

The role of immunochemical differences in the phyletic development of human behavior.

1961 • 113 citations

Evolution of a Second Gene for β-Galactosidase in Escherichia coli

1973 • 108 citations

Recombination of DNA Molecules

1966 • 107 citations

Stimulatory capacity of human T and B lymphocytes in the mixed leukocyte culture

1974 • 102 citations

Nonrepetitive DNA Sequence Representation in Sea Urchin Embryo Messenger RNA

1973 • 98 citations

The Evolution of Biochemical Syntheses — Retrospect and Prospect

1965 • 97 citations

Sequence and structure homologies in bacterial and mammalian-type cytochromes

1971 • 93 citations

HYBRIDIZATION PROPERTIES OF DNA SEQUENCES DIRECTING THE SYNTHESIS OF MESSENGER RNA AND HETEROGENEOUS NUCLEAR RNA

1971 • 92 citations

Programs of Gene Action and Progressive Evolution

1976 • 92 citations

L'évolution physiologique : étude des pertes de fonctions chez les microorganismes

1944 • 80 citations

The Evolution of Hemoglobin

1965 • 77 citations

The Absence of Histone in the Bacterium Escherichia coli

1959 • 76 citations

Processes of Organic Evolution.

1972 • 75 citations

A possible role of “inert” heterochromatin in cell differentiation. Action of and competition for “locking” molecules

1974 • 72 citations

ENZYME EVOLUTION: I. THE IMPORTANCE OF UNTRANSLATABLE INTERMEDIATES

1972 • 71 citations

Eukaryote evolution: A view based on cytochromec sequence data

1973 • 71 citations

Origin of the cell: Experiments and premises

1973 • 70 citations

Repetitious and unique sequences in the heterogeneous nuclear and cytoplasmic messenger RNA of mammalian and insect cells

1974 • 69 citations

Heterochromatization as a change of chromosome cycle

1947 • 69 citations

The gills of two species of haemoglobin-free fishes compared to those of other teleosts— with a note on severe anaemia in an eel

1966 • 67 citations

Mutational trends and random processes in the evolution of informational macromolecules

1971 • 64 citations

Ribosomal RNA Homologies among Distantly Related Organisms

1970 • 63 citations

Chemistry and biology of the histones.

1970 • 62 citations

Transcription and Chromatin Structure

1974 • 58 citations

Duplication of Chromosome Parts as a Factor in Evolution

1947 • 56 citations

Evolution of Ribonuclease in Relation to Polypeptide Folding Mechanisms

1972 • 53 citations

DNA Sequences Neighboring the Duck Hemoglobin Genes

1974 • 51 citations

Separation of the proteolytic and esterasic activities of trypsin by reversible structural modifications

1969 • 50 citations

A model of primitive heterotrophic proliferation

1967 • 48 citations

Evolution of mammalian pancreatic ribonucleases

1975 • 48 citations

Content of ATP and ADP in Rabbit Blastocysts

1971 • 47 citations

Catalytic Activities of Thermal Polyanhydro-α-Amino Acids

1969 • 47 citations

XV.—“Ectopic” Pairing and the Distribution of Heterochromatin in the X-Chromosome of Salivary Gland Nuclei of Drosophila melanogaster

1946 • 47 citations

Structural Similarities between α-Lytic Protease of Myxobacter 495 and Elastase

1971 • 46 citations

Formation of rings from Drosophila DNA fragments

1973 • 45 citations

De novo origin of periodic proteins

1972 • 45 citations

The repetition of homologous sequences in the polypetide chains of certain cytochromes and globins.

1966 • 43 citations

Models for the evolution of codon assignments

1969 • 42 citations

The catalytic activity of thermal polyanhydro-α-amino acids for the hydrolysis of p-nitrophenyl acetate

1967 • 39 citations

Studies on the Transfer RNA Genes of Drosophila

1974 • 39 citations

Relation of Protein Evolution to Tertiary Structure

1964 • 37 citations

Opossum Hb chain sequence and neutral mutation theory

1974 • 36 citations

Molecular variants of Golfingia gouldii hemerythrin. Primary structure of the variants arising from five amino acid interchanges

1972 • 32 citations

THE ROLE OF MUTATION IN EVOLUTION

1972 • 31 citations

Change in repeated DNA in evolution.

1972 • 30 citations

Computer analysis of protein sequences

1974 • 25 citations

Conservation of Shannon's redundancy for proteins

1974 • 25 citations

Natural Selection and Mutation Rates in Mammals

1970 • 23 citations

Evolutionary stability of the histone genes of sea urchins

1973 • 22 citations

The number and location of genes for 5S ribonucleic acid within the genome of Drosophila melanogaster

1971 • 21 citations

Location of repetitious DNA in the chromosomes of the desert locust (Schistocerca gregaria)

1974 • 20 citations

Evolution of macromolecular complexity

1971 • 19 citations

Homology and Phylogeny of Proteolytic Enzymes

1970 • 15 citations

Structural and evolutionary relationships of ferredoxins.

1968 • 14 citations

A method for estimating the probability that a specific frameshift mutation was selected in the course of evolution

1970 • 13 citations

Investigations of Molecular Variation in Human Fetal Hemoglobin in the Infant and in Certain Hematological Conditions in the Adult

1970 • 12 citations

Some aspects of protein evolution

1972 • 12 citations

Chance in Evolution--Some Philosophical Remarks

1972 • 9 citations

On some biochemical aspects of regressive evolution in animals

1971 • 8 citations

The possible conservation of genetic information in repetitious sequences of DNA

1972 • 6 citations

The in vitro cellular synthesis of hemoglobin components in various media and its relevance to the concept of stenogenic and eurygenic states of differentiation

1975 • 6 citations

[Polycondensation of free amino acids in aqueous solution by a water-soluble carbodiimide intermediate].

1969 • 5 citations

The cell machinery in its relation to biogenesis.

1970 • 3 citations