Practical aspects in the use of cyclosporin in paediatric nephrology

Biological effects of cyclosporin A: A new antilymphocytic agent

1976 • 1,501 citations

Increased Incidence of Lymphoproliferative Disorder after Immunosuppression with the Monoclonal Antibody OKT3 in Cardiac-Transplant Recipients

1990 • 947 citations

Clinical Pharmacokinetics of Cyclosporin

1986 • 488 citations

A Radioimmunoassay to Measure Cyclosporin a in Plasma and Serum Samples

1981 • 287 citations

Role of lipoproteins and erythrocytes in the in vitro binding and distribution of cyclosporin A in the blood

1982 • 271 citations

Critical issues in cyclosporine monitoring: report of the Task Force on Cyclosporine Monitoring.

1987 • 233 citations

Crystal and Molecular Structure of an Iodo‐derivative of the Cyclic Undecapeptide Cyclosporin A

1976 • 219 citations

Metabolism of cyclosporine.

1985 • 172 citations

Cyclosporine A induced remission of relapsing nephrotic syndrome in children

1988 • 168 citations

Disposition of cyclosporine in several animal species and man. I. Structural elucidation of its metabolites.

1984 • 155 citations

The 1989 report of the North American Pediatric Renal Transplant Cooperative Study

1990 • 154 citations

Cyclosporine Monitoring in Renal Transplantation

1989 • 130 citations

Evaluation of cyclosporin‐phenytoin interaction with observations on cyclosporin metabolites.

1984 • 112 citations

Small-Bowel Length and the Dose of Cyclosporine in Children after Liver Transplantation

1990 • 103 citations

Age-dependent cyclosporine: Pharmacokinetics in marrow transplant recipients

1986 • 92 citations

Abbott TDx monoclonal antibody assay evaluated for measuring cyclosporine in whole blood

1990 • 91 citations

Intravenous cyclosporine kinetics in renal failure

1983 • 91 citations

Tissue distribution, disposition, and metabolism of cyclosporine in rats.

1987 • 90 citations

THE EFFECT OF FOOD ON CYCLOSPORINE ABSORPTION

1985 • 90 citations

Biotransformation and distribution in blood of cyclosporine and its metabolites.

1986 • 89 citations

The pathophysiology of sandimmune (cyclosporine) in man and animals

1990 • 87 citations

Cyclosporin a for the treatment of systemic lupus erythematosus

1981 • 83 citations

IN VITRO IMMUNOSUPPRESSIVE PROPERTIES OF CYCLOSPORINE METABOLITES

1987 • 79 citations

High-performance liquid chromatographic determination of cyclosporin A in human plasma and urine

1980 • 79 citations

IMMUNOSUPPRESSIVE METABOLITES OF CYCLOSPORINE IN THE BLOOD OF RENAL ALLOGRAFT RECIPIENTS

1986 • 75 citations

Pharmacokinetics and Monitoring of Cyclosporine Following Orthotopic Liver Transplantation

1985 • 75 citations

The effects of FK 506 on renal function after liver transplantation.

1990 • 68 citations

Effects of cyclosporine in severe systemic lupus erythematosus

1987 • 67 citations

A clinicopathological study of 24 children with hemolytic uremic syndrome

1990 • 67 citations

The pathophysiology of Sandimmune (cyclosporine) in man and animals

1990 • 67 citations

Interaction between phenytoin and cyclosporine following organ transplantation.

1984 • 65 citations

Adverse Reactions and Interactions of Cyclosporin

1988 • 61 citations

The Effects of Erythromycin in Patients Treated with Cyclosporine

1986 • 60 citations

The transport of cyclosporine in association with plasma lipoproteins in heart and liver transplant patients.

1985 • 53 citations

Cyclosporin-associated nephropathy in patients with autoimmune diseases

1988 • 53 citations

Dosage of Cyclosporin A in children with renal transplants.

1984 • 52 citations

Cyclosporin A in nephrotic syndrome of childhood--a 14 month experience.

1986 • 51 citations

Cyclosporin‐phenytoin interaction: re‐evaluation using metabolite data.

1987 • 48 citations

Effect of hematocrit on cyclosporine (cyclosporin A) in whole blood and plasma of renal-transplant patients.

1985 • 47 citations

Absorption of cyclosporine A after oral dosing.

1986 • 44 citations

Cyclosporine monitoring in liver allograft recipients: two distinct patterns of blood level derangement associated with nephrotoxicity.

1990 • 41 citations

CYCLOSPORINE AND KETOCONAZOLE

1984 • 40 citations

Cyclosporine and ketoconazole.

1984 • 40 citations

Cyclosporin: Mode of Action and Clinical Applications

1990 • 40 citations

Enhancement of high dose cyclosporin A toxicity by frusemide

1984 • 40 citations

Therapy of focal segmental glomerulosclerosis with cyclosporine A

1987 • 38 citations

Cyclosporine and metabolites in blood from renal allograft recipients with nephrotoxicity, rejection, or good renal function: comparative high-performance liquid chromatography and monoclonal radioimmunoassay studies.

1988 • 35 citations

Metabolism of cyclosporin A. III. Interaction of the macrolide antibiotic, erythromycin, using rabbit hepatocytes and microsomal fractions.

1988 • 34 citations

Cyclosporine metabolites in human blood and renal tissue.

1986 • 34 citations

Distribution and concentration of cyclosporin in human blood.

1984 • 33 citations

Serious interaction between cyclosporin A and sulphadimidine.

1986 • 33 citations

Biologic significance of cyclosporine metabolites.

1988 • 32 citations

Measurement of cyclosporine and 18 metabolites in blood, bile, and urine by high-performance liquid chromatography.

1988 • 32 citations

Severe nephrotoxicity caused by the combined use of gentamicin and cyclosporine in renal allograft recipients.

1986 • 32 citations

The place of cyclosporine A in the treatment of connective tissue diseases.

1988 • 30 citations

Cyclosporin a treatment in children with minimal change nephrotic syndrome and focal segmental glomerulosclerosis

1988 • 30 citations

The role of drug metabolism in cyclosporine A nephrotoxicity.

1986 • 29 citations

Deposition of nine metabolites of cyclosporine in human tissues, bile, urine, and whole blood.

1988 • 25 citations

Cyclosporine treatment of nephrotic syndrome in children.

1988 • 25 citations

Four Years' Experience with Cyclosporin A in Pediatric Kidney Transplantation¹

1990 • 23 citations

Treatment of systemic lupus erythematosus

1986 • 21 citations

The chronopharmacokinetics of cyclosporine and its metabolites in recipients of pancreas allografts.

1988 • 21 citations

Pharmacology of cyclosporine (sandimmune). III. Immunochemistry and monitoring.

1990 • 21 citations

Effect of the application form of cyclosporine on blood levels: comparison of oral solution and capsules.

1988 • 21 citations

Acute interstitial nephritis after a Russell's viper snake bite.

1986 • 20 citations

Cyclosporine-cimetidine interaction.

1988 • 19 citations

The possible relationship between hepatic drug metabolism and ketoconazole enhancement of cyclosporine nephrotoxicity.

1985 • 19 citations

Immunosuppressive effect of cyclosporine metabolites from human bile on alloreactive T cells.

1988 • 18 citations

Cyclosporine and childhood idiopathic nephrosis.

1988 • 17 citations

Assessment of Cyclosporin A in Whole Blood and Plasma in Five Patients with Different Hematocrits

1985 • 17 citations

Tissue distribution of cyclosporine A in the mouse: a clue to toxicity?

1986 • 13 citations

EFFECT OF CYCLOSPORINE, CYCLOSPORINE METABOLITE 17, AND OTHER CYCLOSPORINE-RELATED COMPOUNDS ON T LYMPHOCYTE CLONES DERIVED FROM REJECTED HUMAN KIDNEY GRAFTS I. INHIBITION OF PROLIFERATION

1987 • 13 citations

Cyclosporine A for treatment of nephrotic syndromes.

1988 • 12 citations

Effect of phenobarbital and cimetidine on experimental cyclosporine nephrotoxicity: preliminary observations.

1986 • 11 citations

Cyclosporin A Metabolism and Drug Interactions

1989 • 10 citations

Effects of cyclosporine metabolites M17 and M18 on proliferation and interleukin 2 production in the mixed lymphocyte culture.

1987 • 10 citations

The nephrotoxic effects of cyclosporine metabolites.

1988 • 9 citations

A rapid and specific assay for the du Pont aca discrete clinical analyzer, performed directly on whole blood.

1990 • 9 citations

Enhanced clearance of vancomycin by hemodialysis in a child

1989 • 9 citations

Effects of initial cyclosporine dose and timing on long‐term creatinine levels in cadaver renal transplantation

1990 • 9 citations

An evaluation of cyclosporine monitoring by nonselective fluorescence polarization immunoassay.

1990 • 8 citations

Pharmacokinetics of cyclosporin A

1989 • 7 citations

Treatment with cyclosporine of adult idiopathic nephrotic syndrome resistant to corticosteroids and other immunosuppressants.

1988 • 7 citations

Identification of cyclosporine metabolites in human bile, blood, and urine by high-performance liquid chromatography/radioimmunoassay/fast atomic bombardment mass spectroscopy.

1988 • 7 citations

Contribution of cyclosporin metabolites to immunosuppression in liver-transplanted patients with severe graft dysfunction

1991 • 7 citations

Unexpected severe reversible cyclosporine A-induced nephrotoxicity in a patient with systemic lupus erythematosus and tubulointerstitial renal disease.

1988 • 7 citations

Tissue distribution of [3H]cyclosporine A in mice.

1988 • 7 citations

Contribution of cyclosporin metabolites to immunosuppression in liver-transplanted patients with severe graft dysfunction

1991 • 6 citations

Pathological effects of cyclosporin A in clinical practice

1989 • 5 citations

The cyclosporins.

1989 • 4 citations

The measurement of cyclosporine A and metabolite M17 in whole blood by high-performance liquid chromatography.

1988 • 4 citations

[Elevated cyclosporin A level during simultaneous therapy with danazol].

1986 • 3 citations

Ask the expert

1990 • 2 citations

Sandimmun®/An Appraisal of Drug Interactions

1989 • 1 citations

Deleted Work

1955 • 0 citations