In vivo characterisation of novel efficacious muscarinic receptor agonists

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1973 • 12,522 citations

APRIORITY

1961 • 1,293 citations

Neurotransmitter enzyme abnormalities in senile dementia

1977 • 710 citations

Physostigmine and Arecoline: Effects of Intravenous Infusions in Alzheimer Presenile Dementia

1981 • 362 citations

Novel quinuclidine-based ligands for the muscarinic cholinergic receptor

1990 • 155 citations

Relative affinities of drugs acting at cholinoceptors in displacing agonist and antagonist radioligands: the NMS/Oxo‐M ratio as an index of efficacy at cortical muscarinic receptors

1988 • 108 citations

The pharmacological assessment of RS 86 (2-ethyl-8-methyl-2,8-diazaspiro-[4,5]-decan-1,3-dion hydrobromide). A potent, specific muscarinic acetylcholine receptor agonist

1986 • 94 citations

No response to high‐dose muscarinic agonist therapy in Alzheimer's disease

1988 • 80 citations

Pharmacological differences between two muscarinic responses of the rat superior cervical ganglion in vitro

1987 • 54 citations

Direct measurement of muscarinic agents in the central nervous system of mice using ex vivo binding

1989 • 31 citations

Receptor reserve as a tissue misnomer

1986 • 28 citations

Catecholamine release and potentiation of thromboxane A₂ production by nicotine in the greyhound

1986 • 13 citations