Identification of isoprenyl modified proteins metabolically labeled with [³H]farnesyl‐ and [³H]geranylgeranyl‐pyrophosphate

All ras proteins are polyisoprenylated but only some are palmitoylated

1989 • 1,806 citations

Cell Biology: a Laboratory Handbook

1995 • 1,226 citations

Cell biology :a laboratory handbook.

1994 • 1,213 citations

PROTEIN ISOPRENYLATION AND METHYLATION AT CARBOXYL-TERMINAL CYSTEINE RESIDUES

1992 • 885 citations

p21ras is modified by a farnesyl isoprenoid.

1989 • 847 citations

Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity.

1992 • 542 citations

Small GTP-Binding Proteins

1992 • 526 citations

A CAAX or a CAAL motif and a second signal are sufficient for plasma membrane targeting of ras proteins.

1991 • 477 citations

Post-translational processing of p21ras is two-step and involves carboxyl-methylation and carboxy-terminal proteolysis.

1989 • 462 citations

The Phosphorylation State of Eucaryotic Initiation Factor 2 Alters Translational Efficiency of Specific mRNAs

1989 • 393 citations

Posttranslational modification of the Ha-ras oncogene protein: evidence for a third class of protein carboxyl methyltransferases.

1988 • 384 citations

Methylation and proteolysis are essential for efficient membrane binding of prenylated p21K-ras(B).

1991 • 291 citations

Protein prenylation: more than just glue?

1992 • 208 citations

Nonfarnesylated tetrapeptide inhibitors of protein farnesyltransferase

1991 • 183 citations

The Dynamic Properties and Possible Functions of Nuclear Lamins

1996 • 179 citations

The phosphorylation state of eucaryotic initiation factor 2 alters translational efficiency of specific mRNAs.

1989 • 163 citations

cDNA cloning of MEV, a mutant protein that facilitates cellular uptake of mevalonate, and identification of the point mutation responsible for its gain of function

1992 • 124 citations

Quantitation of prenylcysteines by a selective cleavage reaction.

1991 • 120 citations

The human keratinocyte two‐dimensional gel protein database (update 1995): Mapping components of signal transduction pathways

1995 • 115 citations

PxF, a prenylated protein of peroxisomes.

1994 • 107 citations

Chemical biology of protein isoprenylation/methylation

1996 • 98 citations

Development of Highly Potent Inhibitors of Ras Farnesyltransferase Possessing Cellular andin VivoActivity

1996 • 87 citations

Expression of normal and mutant ras proteins in human acute leukemia.

1987 • 64 citations

Development of inhibitors of protein farnesylation as potential chemotherapeutic agents

1995 • 53 citations

Specific Labeling of Isoprenylated Proteins: Application to Study Inhibitors of the Post-translational Farnesylation and Geranylgeranylation

1995 • 45 citations

Analysis of nuclear lamin isoprenylation in Xenopus oocytes: isoprenylation of lamin B3 precedes its uptake into the nucleus.

1995 • 38 citations

Analysis of ras oncogene products by two-dimensional gel electrophoresis: Evidence for protein families with distinctive molecular forms

1986 • 16 citations

Expression of cDNA clones by coupled in vitro transcription/translation and transfection into COS‐1 cells: Protein mapping in two‐dimensional gels

1995 • 8 citations