Quantitative and functional characteristics of intestinal-homing memory T cells: analysis of Crohn's disease patients and healthy controls

Two subsets of memory T lymphocytes with distinct homing potentials and effector functions

1999 • 5,659 citations

Development of a Crohn's disease activity index. National Cooperative Crohn's Disease Study.

1976 • 3,140 citations

Development of a Crohn's Disease Activity Index

1976 • 3,024 citations

Inflammatory bowel disease: Etiology and pathogenesis

1998 • 2,095 citations

α4β7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1

1993 • 1,427 citations

Detection of intracellular cytokines by flow cytometry

1993 • 992 citations

Tolerance exists towards resident intestinal flora but is broken in active inflammatory bowel disease (IBD)

1995 • 965 citations

P- and E-selectin mediate recruitment of T-helper-1 but not T-helper-2 cells into inflamed tissues

1997 • 735 citations

Role of alpha 4-integrins in lymphocyte homing to mucosal tissues in vivo.

1994 • 625 citations

Blocking Smad7 restores TGF-β1 signaling in chronic inflammatory bowel disease

2001 • 571 citations

Critical role for β7 integrins in formation of the gut-associated lymphoid tissue

1996 • 558 citations

Control of intestinal inflammation by regulatory T cells

2001 • 496 citations

Altered Th1/Th2 cytokine profiles in the intestinal mucosa of patients with inflammatory bowel disease as assessed by quantitative reversed transcribed polymerase chain reaction (RT-PCR)

1995 • 400 citations

CURRENT CONCEPTS OF THE ETIOLOGY AND PATHOGENESIS OF ULCERATIVE COLITIS AND CROHN’S DISEASE

1995 • 398 citations

CD4+ T Cells Reactive to Enteric Bacterial Antigens in Spontaneously Colitic C3H/HeJBir Mice: Increased T Helper Cell Type 1 Response and Ability to Transfer Disease

1998 • 393 citations

Expression of transforming growth factors alpha and beta in colonic mucosa in inflammatory bowel disease

1996 • 388 citations

Monoclonal antibodies specific for beta 7 integrin and mucosal addressin cell adhesion molecule-1 (MAdCAM-1) reduce inflammation in the colon of scid mice reconstituted with CD45RBhigh CD4+ T cells.

1997 • 364 citations

Tolerance towards resident intestinal flora in mice is abrogated in experimental colitis and restored by treatment with interleukin‐10 or antibodies to interleukin‐12

1996 • 358 citations

Expression and function of the MAdCAM-1 receptor, integrin alpha 4 beta 7, on human leukocytes.

1994 • 350 citations

CCR7 Expression and Memory T Cell Diversity in Humans

2001 • 342 citations

Rapid resolution of chronic colitis in the cotton-top tamarin with an antibody to a gut-homing integrin alpha 4 beta 7

1996 • 329 citations

Control of immune pathology by regulatory T cells

1998 • 289 citations

Selective expression of integrin alpha 4 beta 7 on a subset of human CD4+ memory T cells with Hallmarks of gut-trophism.

1993 • 254 citations

Regulation of CD27 expression on subsets of mature T-lymphocytes.

1993 • 247 citations

Expression of lymphocyte-endothelial receptor-ligand pairs, alpha 4beta 7/MAdCAM-1 and OX40/OX40 ligand in the colon and jejunum of patients with inflammatory bowel disease

1999 • 214 citations

Homing of naive and memory T lymphocyte subsets to Peyer's patches, lymph nodes, and spleen.

1997 • 181 citations

Homing potentials of circulating lymphocytes in humans depend on the site of activation: oral, but not parenteral, typhoid vaccination induces circulating antibody-secreting cells that all bear homing receptors directing them to the gut.

1997 • 156 citations

Expression of mucosal homing receptor alpha4beta7 by circulating CD4+ cells with memory for intestinal rotavirus.

1997 • 149 citations

Structure and function of adhesion receptors in leukocyte trafficking

1995 • 145 citations

Peripheral monocyte and naive T-cell recruitment and activation in Crohn's disease

1995 • 127 citations

Differential expression of homing molecules on recirculating lymphocytes from sheep gut, peripheral, and lung lymph.

1996 • 123 citations

Intracellular cytokine production by human CD4+ and CD8+ T cells from normal and immunodeficient donors using directly conjugated anti-cytokine antibodies and three-colour flow cytometry

1996 • 108 citations

Altered expression of alpha 4 beta 7, a gut homing integrin, by circulating and mucosal T cells in colonic mucosal inflammation.

1997 • 103 citations

Human Peyer’s Patch T Cells Are Sensitized to Dietary Antigen and Display a Th Cell Type 1 Cytokine Profile

2000 • 92 citations

Phenotype, and migration properties of three major subsets of tissue homing T cells in sheep

1996 • 90 citations

Expression of the Mucosal Homing Receptor α₄β₇Correlates with the Ability of CD8⁺Memory T Cells To Clear Rotavirus Infection

1998 • 83 citations

Quantification and cytokine production of circulating lymphoid and myeloid cells in acute myelogenous leukaemia

2003 • 79 citations

Mechanisms of lymphocyte homing

1992 • 76 citations

T cell chemokine receptor expression in human Th1- and Th2-associated diseases.

2000 • 67 citations

Control of Experimental Inflammatory Bowel Disease by Regulatory T cells

2000 • 63 citations

Molecules controlling lymphocyte migration to the gut

1999 • 52 citations

Spatial heterogeneity of TNF-α-induced T cell migration to colonic mucosa is mediated by MAdCAM-1 and VCAM-1

2002 • 42 citations

Interleukin-10 expression in intestine of Crohn disease.

2000 • 25 citations

Preferential production of interferon‐γ by CD4⁺ T cells expressing the homing receptor integrin α₄/β₇

2001 • 19 citations

Decreased Lamina Propria Effector Cell Responsiveness to Interleukin-10 in Ileal Crohn's Disease

2002 • 18 citations

LDP-02 (Millenium).

2001 • 10 citations