Exploring type I angiotensin (AT₁) receptor functions through gene targeting

Establishment in culture of pluripotential cells from mouse embryos

1981 • 8,424 citations

Altering the Genome by Homologous Recombination

1989 • 2,021 citations

Molecular basis of human hypertension: Role of angiotensinogen

1992 • 1,861 citations

Angiotensin II receptors and angiotensin II receptor antagonists.

1993 • 1,843 citations

Effect of the Angiotensin-Converting–Enzyme Inhibitor Benazepril on the Progression of Chronic Renal Insufficiency

1996 • 1,759 citations

Control of glomerular hypertension limits glomerular injury in rats with reduced renal mass.

1985 • 931 citations

Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor

1995 • 858 citations

Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor gene in mice

1995 • 740 citations

Angiotensin II type 1 receptor gene polymorphisms in human essential hypertension.

1994 • 731 citations

Functions of Angiotensin in the Central Nervous System

1987 • 726 citations

Molecular cloning of a novel angiotensin II receptor isoform involved in phosphotyrosine phosphatase inhibition.

1993 • 713 citations

The angiotensin II type 2 (AT2) receptor antagonizes the growth effects of the AT1 receptor: gain-of-function study using gene transfer.

1995 • 688 citations

Integration and Stable Germ Line Transmission of Genes Injected into Mouse Pronuclei

1981 • 665 citations

Male–female differences in fertility and blood pressure in ACE-deficient mice

1995 • 644 citations

Genetic control of blood pressure and the angiotensinogen locus.

1995 • 627 citations

Regulation of blood pressure by the type 1A angiotensin II receptor gene.

1995 • 599 citations

Renal injury from angiotensin II-mediated hypertension.

1992 • 546 citations

Expression of AT2 receptors in the developing rat fetus.

1991 • 537 citations

Angiotensin I-converting enzyme in human circulating mononuclear cells: genetic polymorphism of expression in T-lymphocytes

1993 • 518 citations

Interactions of Transforming Growth Factor-β and Angiotensin II in Renal Fibrosis

1998 • 441 citations

Mice lacking angiotensin-converting enzyme have low blood pressure, renal pathology, and reduced male fertility.

1996 • 438 citations

Role of the Angiotensin Type 2 Receptor in the Regulation of Blood Pressure and Renal Function

2000 • 417 citations

Expression of Angiotensin Type-1 (AT1) and Type-2 (AT2) Receptor mRNAs in the Adult Rat Brain: A Functional Neuroanatomical Review

1997 • 408 citations

Angiotensin II Type 1a Receptor-deficient Mice with Hypotension and Hyperreninemia

1995 • 368 citations

Inhibition of mesangial cell proliferation and matrix expansion in glomerulonephritis in the rat by antibody to platelet-derived growth factor.

1992 • 345 citations

Gene targeting in mice reveals a requirement for angiotensin in the development and maintenance of kidney morphology and growth factor regulation.

1995 • 340 citations

Angiotensin II directly stimulates sodium transport in rabbit proximal convoluted tubules.

1984 • 338 citations

Murine double nullizygotes of the angiotensin type 1A and 1B receptor genes duplicate severe abnormal phenotypes of angiotensinogen nullizygotes.

1998 • 338 citations

The temporal integration of the aldosterone secretory response to angiotensin occurs via two intracellular pathways.

1984 • 332 citations

Angiotensin II receptor antagonist ameliorates renal tubulointerstitial fibrosis caused by unilateral ureteral obstruction

1995 • 332 citations

Angiotensin-converting enzyme inhibitor fetopathy.

1993 • 327 citations

Reduced growth, abnormal kidney structure, and type 2 (AT ₂ ) angiotensin receptor-mediated blood pressure regulation in mice lacking both AT _1A and AT _1B receptors for angiotensin II

1998 • 316 citations

Angiotensin II regulates cellular immune responses through a calcineurin-dependent pathway

1999 • 305 citations

Increased expression of TGF-β1 mRNA in the obstructed kidney of rats with unilateral ureteral ligation

1993 • 295 citations

The critical role of tissue angiotensin-converting enzyme as revealed by gene targeting in mice.

1997 • 276 citations

Molecular cloning and sequencing of the gene encoding human angiotensin II type 1 receptor

1992 • 225 citations

Urinary concentrating ability: insights from comparative anatomy

1985 • 222 citations

Divergent functions of angiotensin II receptor isoforms in the brain

2000 • 192 citations

Tissue-specific expression of type 1 angiotensin II receptor subtypes. An in situ hybridization study.

1994 • 182 citations

Targeting deletion of angiotensin type 1B receptor gene in the mouse

1997 • 178 citations

Developmental expression of renal angiotensin II receptor genes in the mouse

1995 • 159 citations

Angiotensin-Converting Enzyme Gene Mutations, Blood Pressures, and Cardiovascular Homeostasis

1997 • 156 citations

Angiotensin-independent mechanism for aldosterone synthesis during chronic extracellular fluid volume depletion.

1997 • 155 citations

Renin-dependent Cardiovascular Functions and Renin-independent Blood-Brain Barrier Functions Revealed by Renin-deficient Mice

2000 • 152 citations

Regression of sclerosis in aging by an angiotensin inhibition-induced decrease in PAI-1

2000 • 145 citations

Induction of angiotensin converting enzyme in human monocytes in culture

1978 • 143 citations

Renal Interstitial Fibrosis Is Reduced in Angiotensin II Type 1a Receptor-Deficient Mice

2001 • 143 citations

Delayed treatment with enalapril halts tubulointerstitial fibrosis in rats with obstructive nephropathy

1996 • 142 citations

Inhibition by atrial and brain natriuretic peptides of endothelin-1 secretion after stimulation with angiotensin II and thrombin of cultured human endothelial cells.

1991 • 136 citations

A DNA polymorphism, consistent with gene duplication, correlates with high renin levels in the mouse submaxillary gland

1982 • 126 citations

The angiotensin receptor subtype AT1A predominates in rat forebrain areas involved in blood pressure, body fluid homeostasis and neuroendocrine control

1995 • 124 citations

Expression of Murine Renin Genes during Fetal Development

1990 • 119 citations

Renin and angiotensinogen gene expression in maturing rat kidney

1988 • 112 citations

Importance of Efferent Arteriolar Vascular Tone in Regulation of Proximal Tubule Fluid Reabsorption and Glomerulotubular Balance in the Rat

1980 • 107 citations

Regulation of Sodium Balance and Blood Pressure by the AT _1A Receptor for Angiotensin II

2000 • 105 citations

Absence of tubuloglomerular feedback responses in AT1A receptor-deficient mice

1997 • 105 citations

Chimeric mice carrying 'regional' targeted deletion of the angiotensin type 1A receptor gene. Evidence against the role for local angiotensin in the in vivo feedback regulation of renin synthesis in juxtaglomerular cells.

1996 • 101 citations

Abnormal water metabolism in mice lacking the type 1A receptor for ANG II

2000 • 100 citations

Loss of cytoskeletal support is not sufficient for anoxic plasma membrane disruption in renal cells

1997 • 96 citations

Leukocytes synthesize angiotensinogen.

1993 • 94 citations

Irreversible tubulointerstitial damage associated with chronic aminonucleoside nephrosis. Amelioration by angiotensin I converting enzyme inhibition.

1990 • 91 citations

Differential regulation of rat AT1a and AT1b receptor mRNA

1992 • 90 citations

Tubuloglomerular Feedback and Single Nephron Function after Converting Enzyme Inhibition in the Rat

1979 • 90 citations

Angiotensin II Activates Collagen Type I Gene in the Renal Vasculature of Transgenic Mice During Inhibition of Nitric Oxide Synthesis

1999 • 88 citations

Vanadate and fluoride effects on Na+-K+-Cl- cotransport in squid giant axon

1988 • 85 citations

Genetic deficiency of angiotensinogen produces an impaired urine concentrating ability in mice

1998 • 78 citations

Captopril Prevents Experimental Autoimmune Myocarditis

2003 • 76 citations

Angiotensin II Receptor Antagonist TCV-116 Reduces Graft Coronary Artery Disease and Preserves Graft Status in a Murine Model

1996 • 74 citations

Renin Is Expressed in Rat Macrophage/Monocyte Cells

1996 • 71 citations

Renal function in the AT1A receptor knockout mouse during normal and volume-expanded conditions

1999 • 67 citations

A Mouse View of Hypertension

1997 • 66 citations

An angiotensin II receptor antagonist reduces myocardial damage in an animal model of myocarditis.

1994 • 64 citations

EVOLUTION AND VARIATION OF RENIN GENES IN MICE

1984 • 63 citations

1166 A/C Polymorphism of the Angiotensin II Type 1 Receptor Gene and the Response to Short-Term Infusion of Angiotensin II

1999 • 59 citations

Improved Survival in Rats Administered NG-Nitro L-Arginine Methyl Ester Due to Converting Enzyme Inhibition

1996 • 59 citations

Renal Vascular Reactivity in Mice

1999 • 56 citations

The effects of blood pressure reduction on cyclosporine nephrotoxicity in the rat.

1993 • 55 citations

Neuroendocrine Effects of Dehydration in Mice Lacking the Angiotensin AT1a Receptor

1999 • 52 citations

Regulation of renal growth factors and clusterin by AT1 receptors during neonatal ureteral obstruction

1995 • 47 citations

Tubuloglomerular feedback in ACE-deficient mice

1999 • 44 citations

Enhanced central response to dehydration in mice lacking angiotensin AT_1areceptors

2001 • 38 citations

Etude par microponction de l’élaboration de l’urine

1969 • 37 citations

Angiotensin II AT1-Receptor Blockade Inhibits Monocyte Activation and Adherence in Transgenic (mRen2)27 Rats

1999 • 34 citations

Mediators of perivascular inflammation in the left ventricle of renovascular hypertensive rats

1996 • 31 citations

Physiological Impact of Increased Expression of the AT ₁ Angiotensin Receptor

2003 • 31 citations

Mouse angiotensin receptor genes Agtrla and Agtr1b map to Chromosomes 13 and 3

1997 • 28 citations

Regression by ACE inhibition of arteriosclerotic changes induced by chronic blockade of NO synthesis in rats

2001 • 18 citations

Etude par microponction de l’élaboration de l’urine

1970 • 11 citations

Mediators of perivascular inflammation in the left ventricle of renovascular hypertensive rats

1996 • 8 citations