Angiotensin II Receptor Antagonist TCV-116 Reduces Graft Coronary Artery Disease and Preserves Graft Status in a Murine Model

Molecular characterization of angiotensin II--induced hypertrophy of cardiac myocytes and hyperplasia of cardiac fibroblasts. Critical role of the AT1 receptor subtype.

1993 • 1,420 citations

Inhibitors of Angiotensin-Converting Enzyme Prevent Myointimal Proliferation After Vascular Injury

1989 • 1,061 citations

Identification of a highly specific chymase as the major angiotensin II-forming enzyme in the human heart.

1990 • 878 citations

Angiotensin II induces smooth muscle cell proliferation in the normal and injured rat arterial wall.

1991 • 751 citations

Vascular smooth muscle cell hypertrophy vs. hyperplasia. Autocrine transforming growth factor-beta 1 expression determines growth response to angiotensin II.

1992 • 648 citations

Induction of platelet-derived growth factor A-chain and c-myc gene expressions by angiotensin II in cultured rat vascular smooth muscle cells.

1989 • 632 citations

Development of coronary artery disease in cardiac transplant patients receiving immunosuppressive therapy with cyclosporine and prednisone.

1987 • 549 citations

Does the new angiotensin converting enzyme inhibitor cilazapril prevent restenosis after percutaneous transluminal coronary angioplasty? Results of the MERCATOR study: a multicenter, randomized, double-blind placebo-controlled trial. Multicenter European Research Trial with Cilazapril after Angioplasty to Prevent Transluminal Coronary Obstruction and Restenosis (MERCATOR) Study Group.

1992 • 548 citations

Accelerated coronary vascular disease in the heart transplant patient: Coronary arteriographic findings

1988 • 513 citations

Antiatherogenic effect of captopril in the Watanabe heritable hyperlipidemic rabbit.

1990 • 419 citations

Restenosis after percutaneous transluminal coronary angioplasty: Pathologic observations in 20 patients

1991 • 411 citations

Cellular localization and regional distribution of an angiotensin II-forming chymase in the heart.

1993 • 397 citations

Angiotensin II is mitogenic in neonatal rat cardiac fibroblasts.

1993 • 391 citations

Identification of functional angiotensin II receptors on rat cardiac fibroblasts.

1993 • 361 citations

Angiotensin II receptor antagonist TCV-116 induces regression of hypertensive left ventricular hypertrophy in vivo and inhibits the intracellular signaling pathway of stretch-mediated cardiomyocyte hypertrophy in vitro.

1994 • 252 citations

Role of kinins and nitric oxide in the effects of angiotensin converting enzyme inhibitors on neointima formation.

1993 • 233 citations

Clinical and laboratory correlates of accelerated coronary artery disease in the cardiac transplant patient.

1987 • 196 citations

Molecular mechanisms of vascular renin-angiotensin system in myointimal hyperplasia.

1991 • 195 citations

Retransplantation for severe accelerated coronary artery disease in heart transplant recipients

1988 • 193 citations

Studies on the pathogenesis of atheroarteriosclerosis induced in rabbit cardiac allografts by the synergy of graft rejection and hypercholesterolemia.

1977 • 171 citations

CHRONIC VASCULAR REJECTION OF THE HEART AND THE KIDNEY—HAVE RATIONAL TREATMENT OPTIONS EMERGED?

1992 • 152 citations

Complications in long-term survivors of cardiac transplantation.

1981 • 149 citations

PATHOGENESIS AND PREVENTION OF GRAFT ARTERIOSCLEROSIS IN AN EXPERIMENTAL HEART TRANSPLANT MODEL

1981 • 144 citations

EXPERIMENTAL GRAFT ARTERIOSCLEROSIS

1992 • 143 citations

Vascular Renin-Angiotensin System and Vascular Protection

1993 • 87 citations

Angiotensin-converting enzyme inhibition with fosinopril sodium in the prevention of restenosis after coronary angioplasty.

1994 • 75 citations

The cellular biology of angiotensin: Paracrine, autocrine and intracrine actions in cardiovascular tissues

1989 • 71 citations

An angiotensin II receptor antagonist reduces myocardial damage in an animal model of myocarditis.

1994 • 64 citations

Enhanced expression of superoxide dismutase messenger RNA in viral myocarditis. An SH-dependent reduction of its expression and myocardial injury.

1993 • 60 citations

Angiotensin II‐induced vascular smooth muscle cell hypertrophy: PDGF A‐chain mediates the increase in cell size

1993 • 56 citations

Frequency and consequences of intimal hyperplasia in specimens retrieved by directional atherectomy of native primary coronary artery stenoses and subsequent restenoses

1993 • 55 citations

TCV-116, a novel angiotensin II receptor antagonist, prevents intimal thickening and impairment of vascular function after carotid injury in rats.

1993 • 52 citations

Captopril and immune regulation

1984 • 46 citations

Captopril reduces graft coronary artery disease in a rat heterotopic transplant model.

1993 • 45 citations

Peptide Vasoconstrictors, Vessel Structure, and Vascular Smooth-Muscle Proliferation

1993 • 44 citations

Effects of angiotensin-converting enzyme inhibition with perindopril on hemodynamics, arterial structure, and wall rheology in the hindquarters of atherosclerotic mini-pigs

1993 • 43 citations

Endothelium-Derived Bradykinin

1993 • 41 citations

Angiotensin II is chemotactic for a T-cell subset which can express migration inhibition factor activity in murine schistosomiasis mansoni

1987 • 36 citations

Converting Enzyme Inhibitors and the Interaction Between Kinins and Eicosanoids

1990 • 34 citations

Experimental Graft Coronary Artery Disease in a Murine Heterotopic Cardiac Transplant Model

1995 • 29 citations

Is acute cardiac rejection a model of myocarditis in humans?

1987 • 26 citations

SYNERGISM BETWEEN ALLOANTIBODIES OR F(ab??)2 AND PREDNISONE IN THE SURVIVAL OF MURINE SPLIT HEART ALLOGRAFTS

1973 • 18 citations