Molecular determinants of UCN-01-induced growth inhibition in human lung cancer cells

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1983 • 52,849 citations

Cell Growth & Differentiation

1992 • 558 citations

Cooperation of the tumour suppressors IRF-1 and p53 in response to DNA damage

1996 • 326 citations

Unpredicted clinical pharmacology of UCN-01 caused by specific binding to human alpha1-acid glycoprotein.

1998 • 198 citations

Antitumor activity of UCN-01, a selective inhibitor of protein kinase C, in murine and human tumor models.

1991 • 187 citations

Differential inhibition of protein kinase C isozymes by UCN-01, a staurosporine analogue.

1994 • 161 citations

G1 phase accumulation induced by UCN-01 is associated with dephosphorylation of Rb and CDK2 proteins as well as induction of CDK inhibitor p21/Cip1/WAF1/Sdi1 in p53-mutated human epidermoid carcinoma A431 cells.

1997 • 155 citations

Apoptosis in 7-hydroxystaurosporine-treated T lymphoblasts correlates with activation of cyclin-dependent kinases 1 and 2.

1995 • 137 citations

Cell cycle arrest and growth inhibition by the protein kinase antagonist UCN-01 in human breast carcinoma cells.

1993 • 133 citations

UCN-01, 7-Hydroxyl-staurosporine, Inhibits Kinase Activity of Cyclin-Dependent Kinases and Reduces the Phosphorylation of the Retinoblastoma Susceptibility Gene Product in A549 Human Lung Cancer Cell Line

1996 • 117 citations

Effect of UCN-01, a selective inhibitor of protein kinase C, on the cell-cycle distribution of human epidermoid carcinoma, A431 cells

1994 • 92 citations

Blocking of glioma proliferation in vitro and in vivo and potentiating the effects of BCNU and cisplatin: UCN-01, a selective protein kinase C inhibitor

1996 • 74 citations

Potent selective inhibition of 7-O-methyl UCN-01 against protein kinase C.

1990 • 45 citations

Establishment and characterization of an etoposide-resistant human small cell lung cancer cell line.

1992 • 25 citations

Characterisation of novel human lung carcinoma cell lines selected for resistance to anti-neoplastic analogues of staurosporine

1997 • 20 citations