Biopharmaceutics Classification by High Throughput Solubility Assay and PAMPA

A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability.

1995 • 5,050 citations

Drug-like properties and the causes of poor solubility and poor permeability

2000 • 3,405 citations

Characterization of the Human Colon Carcinoma Cell Line (Caco-2) as a Model System for Intestinal Epithelial Permeability

1989 • 2,127 citations

Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells

1991 • 1,787 citations

Physicochemical High Throughput Screening: Parallel Artificial Membrane Permeation Assay in the Description of Passive Absorption Processes

1998 • 1,205 citations

MDCK (Madin-Darby Canine Kidney) Cells: A Tool for Membrane Permeability Screening

1999 • 895 citations

Physicochemical Profiling (Solubility, Permeability and Charge State)

2001 • 567 citations

In vitro–in vivo correlations for lipophilic, poorly water-soluble drugs

2000 • 557 citations

High throughput physicochemical profiling for drug discovery

2001 • 344 citations

A High-Throughput Screening Method for the Determination of Aqueous Drug Solubility Using Laser Nephelometry in Microtiter Plates

2000 • 333 citations

High Throughput Prediction of Oral Absorption: Improvement of the Composition of the Lipid Solution Used in Parallel Artificial Membrane Permeation Assay

2001 • 192 citations

Link between drug absorption solubility and permeability measurements in Caco-2 cells

1998 • 180 citations

Dissolution of Ionizable Water‐Insoluble Drugs: The Combined Effect of pH and Surfactant

2000 • 155 citations

Optimized conditions of bio-mimetic artificial membrane permeation assay

2001 • 148 citations

Prediction of human intestinal permeability using artificial membrane permeability

2003 • 109 citations

Determination of the Aqueous Solubility of Drugs Using a Convenient 96-Well Plate-Based Assay

2001 • 46 citations

Physicochemical Profiling (Solubility, Permeability and Charge State)

2004 • 26 citations