Optimized conditions of bio-mimetic artificial membrane permeation assay

Drug-like properties and the causes of poor solubility and poor permeability

2000 • 3,405 citations

Characterization of the Human Colon Carcinoma Cell Line (Caco-2) as a Model System for Intestinal Epithelial Permeability

1989 • 2,127 citations

Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells

1991 • 1,787 citations

Physicochemical High Throughput Screening: Parallel Artificial Membrane Permeation Assay in the Description of Passive Absorption Processes

1998 • 1,205 citations

Optimized conditions for prediction of intestinal drug permeability using Caco-2 cells

2000 • 533 citations

On the mechanism of intestinal absorption of drugs.

1959 • 447 citations

Correlation of Human Jejunal Permeability (in Vivo) of Drugs with Experimentally and Theoretically Derived Parameters. A Multivariate Data Analysis Approach

1998 • 436 citations

Estimation of the aqueous solubility I: Application to organic nonelectrolytes

2001 • 347 citations

Prediction of Human Intestinal Absorption of Drug Compounds from Molecular Structure

1998 • 341 citations

Estimating human oral fraction dose absorbed: a correlation using rat intestinal membrane permeability for passive and carrier-mediated compounds.

1988 • 290 citations

Role of the Development Scientist in Compound Lead Selection and Optimization

2000 • 247 citations

Intestinal transport of beta-lactam antibiotics: analysis of the affinity at the H+/peptide symporter (PEPT1), the uptake into Caco-2 cell monolayers and the transepithelial flux.

1999 • 202 citations

High Throughput Prediction of Oral Absorption: Improvement of the Composition of the Lipid Solution Used in Parallel Artificial Membrane Permeation Assay

2001 • 192 citations

Ionization constants of weak acids and bases in organic solvents

1999 • 148 citations

Determination of acid surface pH in vivo in rat proximal jejunum.

1983 • 131 citations

In vitro permeability through caco-2 cells is not quantitatively predictive of in vivo absorption for peptide-like drugs absorbed via the dipeptide transporter system.

1996 • 112 citations

Does fluid flow across the intestinal mucosa affect quantitative oral drug absorption? Is it time for a reevaluation?

1995 • 104 citations

Chromatographic retention of drug molecules on immobilised liposomes prepared from egg phospholipids and from chemically pure phospholipids

2001 • 103 citations

Structure-function relationships in intestinal brush border membranes

1991 • 79 citations

Intestinal surface acid microclimate in vitro and in vivo in the rat.

1986 • 58 citations

Radioligand-binding assay employing P-glycoprotein-overexpressing cells: testing drug affinities to the secretory intestinal multidrug transporter.

1998 • 44 citations

The structure and electrochemical properties of a polymer-supported lipid biosensor

1980 • 26 citations

Radiotelemetering studies of jejunal pH before and after vagotomy and pyloroplasty.

1968 • 10 citations