Obese (ob) Gene Defects are Rare in Human Obesity

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Positional cloning of the mouse obese gene and its human homologue

1994 • 12,975 citations

Serum Immunoreactive-Leptin Concentrations in Normal-Weight and Obese Humans

1996 • 6,254 citations

Weight-Reducing Effects of the Plasma Protein Encoded by the obese Gene

1995 • 4,457 citations

Effects of the obese Gene Product on Body Weight Regulation in ob / ob Mice

1995 • 4,057 citations

Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects

1995 • 3,730 citations

Identification and expression cloning of a leptin receptor, OB-R

1995 • 3,498 citations

Recombinant Mouse OB Protein: Evidence for a Peripheral Signal Linking Adiposity and Central Neural Networks

1995 • 3,302 citations

Abnormal splicing of the leptin receptor in diabetic mice

1996 • 2,361 citations

Body Weight and Mortality among Women

1995 • 2,018 citations

The role of neuropeptide Y in the antiobesity action of the obese gene product

1995 • 1,521 citations

An Adoption Study of Human Obesity

1986 • 1,308 citations

Obese and diabetes: Two mutant genes causing diabetes-obesity syndromes in mice

1978 • 1,274 citations

Phenotypes of Mouse diabetes and Rat fatty Due to Mutations in the OB (Leptin) Receptor

1996 • 1,074 citations

Overexpression of the obese (ob) gene in adipose tissue of human obese subjects

1995 • 716 citations

Increased obese mRNA expression in omental fat cells from massively obese humans

1995 • 527 citations

Increased expression in adipocytes of ob RNA in mice with lesions of the hypothalamus and with mutations at the db locus.

1995 • 466 citations

Genetic and Nongenetic Determinants of Regional Fat Distribution

1993 • 464 citations

Human Obese Gene Expression: Adipocyte-Specific Expression and Regional Differences in the Adipose Tissue

1995 • 434 citations

Evidence against either a premature stop codon or the absence of obese gene mRNA in human obesity.

1995 • 367 citations

Morbidity of severely obese subjects

1992 • 324 citations

The adipocyte: Storage depot or node on the energy information superhighway?

1995 • 298 citations

Mortality of severely obese subjects

1992 • 203 citations

The Regulation of Body Weight

1986 • 131 citations

Growth hormone-receptor messenger RNA in the rat ovary: regulation and localization

1993 • 56 citations

The metabolic syndrome of human obesity.

1996 • 7 citations