The polyol pathway and glucose 6-phosphate in human endothelial cells cultured in high glucose concentrations

Methods of Enzymatic Analysis

1975 • 20,446 citations

Nonenzymatic Glycosylation and the Pathogenesis of Diabetic Complications

1984 • 1,012 citations

Retinal Vascular Patterns

1961 • 785 citations

The Sorbitol Pathway and the Complications of Diabetes

1973 • 750 citations

Diabetic cataract formation: potential role of glycosylation of lens crystallins.

1978 • 411 citations

Glucose Toxicity for Human Endothelial Cells in Culture: Delayed Replication, Disturbed Cell Cycle, and Accelerated Death

1985 • 299 citations

High glucose induces DNA damage in cultured human endothelial cells.

1986 • 244 citations

Aldose reductase in diabetic complications of the eye

1979 • 237 citations

The autoxidation of glyceraldehyde and other simple monosaccharides under physiological conditions catalysed by buffer ions

1984 • 215 citations

Modification of DNA by reducing sugars: a possible mechanism for nucleic acid aging and age-related dysfunction in gene expression.

1984 • 211 citations

Action of Sorbinil in Diabetic Peripheral Nerve: Relationship of Polyol (Sorbitol) Pathway Inhibition to a myo-Inositol-mediated Defect in Sodium-Potassium ATPase Activity

1984 • 178 citations

Nonenzymatic glycosylation of hemoglobin.

1977 • 176 citations

The sorbitol pathway in the human lens: aldose reductase and polyol dehydrogenase.

1981 • 161 citations

Red Cell Sorbitol: An Indicator of Diabetic Control

1980 • 155 citations

The oxidative pentose phosphate cycle. II. Quantitative determination of intermediates and enzymes

1958 • 141 citations

Nonenzymatic Glycosylation Reduces the Susceptibility of Fibrin to Degradation by Plasmin

1983 • 126 citations

Metabolic alterations in the human erythrocyte produced by increases in glucose concentration

1971 • 122 citations

Localization of Aldose Reductase in the Human Eye

1984 • 109 citations

Increased microvascular permeability to plasma proteins in short- and long-term juvenile diabetics.

1976 • 101 citations

The Effect of an Aldose Reductase Inhibitor (Sorbinil) on the Level of Metabolites in Lenses of Diabetic Rats

1983 • 95 citations

The Effects of Acute and Chronic Diabetes on Myocardial Metabolism in Rats

1984 • 86 citations

Pericyte degeneration and acellular capillaries are increased in the feet of human diabetic patients

1985 • 75 citations

Activation of Aldose Reductase from Human Tissues

1985 • 67 citations

Treatment with aldose reductase inhibitor or with myo-inositol arrests deterioration of the electroretinogram of diabetic rats.

1985 • 63 citations

Renal Hypertrophy in Experimental Diabetes: Changes in Pentose Phosphate Pathway Activity

1985 • 61 citations

Studies on the Pathophysiology of Diabetic Retinopathy: The Blood-Retinal Barrier in Diabetes

1983 • 55 citations

Studies on the permeability of the blood-brain barrier in experimental diabetes

1986 • 53 citations

Interaction of human endothelial cells with elevated glucose concentrations and native and glycosylated low density lipoproteins

1984 • 52 citations

Increased microvascular permeability to plasma proteins in short- and long-term juvenile diabetics.

1976 • 50 citations

Analysis by high-performance liquid chromatography of radioactively labeled carbohydrate components of proteoglycans

1986 • 50 citations

Aortic endothelium of alloxan diabetic rabbits: A quantitative study using scanning electron microscopy

1982 • 39 citations

Effects of alloxan diabetes, anti-insulin serum diabetes, and non-diabetic dehydration on brain carbohydrate and energy metabolism in young mice.

1975 • 28 citations

High glucose concentrations partially release hexokinase from inhibition by glucose 6-phosphate.

1985 • 25 citations

Endothelial plasma membrane is a glucocorticoid-regulated barrier for the uptake of glucose into the cell

1985 • 22 citations

Sequence specific damage of DNA induced by reducing sugars

1985 • 17 citations

Myo-inositol enhances the proliferation of human endothelial cells in culture but fails to prevent the delay induced by high glucose

1986 • 11 citations