Hepatocyte injury resulting from the inhibition of mitochondrial respiration at low oxygen concentrations involves reductive stress and oxygen activation

Methods of Enzymatic Analysis

1975 • 20,446 citations

Involvement of the Superoxide Anion Radical in the Autoxidation of Pyrogallol and a Convenient Assay for Superoxide Dismutase

1974 • 9,660 citations

Oxygen-Derived Free Radicals in Postischemic Tissue Injury

1985 • 5,488 citations

Methods of enzymatic analysis

1966 • 4,073 citations

The redox state of free nicotinamide-adenine dinucleotide in the cytoplasm and mitochondria of rat liver

1967 • 1,821 citations

Flavonoids are scavengers of superoxide anions

1988 • 1,596 citations

[4] Isolation and use of liver cells

1978 • 1,230 citations

Superoxide radicals in feline intestinal ischemia

1981 • 1,213 citations

Role of ubiquinone in the mitochondrial generation of hydrogen peroxide

1976 • 656 citations

Oxidation of ascorbic acid with superoxide anion generated by the xanthine-xanthine oxidase system

1975 • 565 citations

Uric acid-iron ion complexes. A new aspect of the antioxidant functions of uric acid

1986 • 538 citations

l-(+)-Lactate

1965 • 507 citations

Simultaneous extraction and reverse-phase high-performance liquid chromatographic determination of adenine and pyridine nucleotides in human red blood cells

1985 • 348 citations

Mitochondria as a source of reactive oxygen species during reductive stress in rat hepatocytes

1993 • 337 citations

Reactive oxygen and ischemia/reperfusion injury of the liver

1991 • 325 citations

The mitochondrial site of superoxide formation

1986 • 208 citations

Effect of anoxia on intracellular ATP, Na+i, Ca2+i, Mg2+i, and cytotoxicity in rat hepatocytes.

1992 • 193 citations

Role of xanthine oxidase in ethanol-induced lipid peroxidation in rats

1990 • 188 citations

Cardiac reperfusion damage prevented by a nitroxide free radical.

1991 • 176 citations

[73] Determination of nonheme iron, total iron, and copper

1967 • 173 citations

Hypoxia, reactive oxygen, and cell injury

1989 • 171 citations

ATP depletion rather than mitochondrial depolarization mediates hepatocyte killing after metabolic inhibition

1994 • 147 citations

Reduced glutathione in combination with superoxide dismutase as an important biological antioxidant defence mechanism

1989 • 139 citations

Treatment with deferoxamine during ischemia improves functional and metabolic recovery and reduces reperfusion-induced oxygen radical generation in rabbit hearts.

1991 • 124 citations

Increase in bleomycin-detectable iron in ischaemia/reperfusion injury to rat kidneys

1993 • 122 citations

1-Bromoalkanes as new potent nontoxic glutathione depletors in isolated rat hepatocytes

1991 • 111 citations

The catecholic metal sequestering agent 1,2-dihydroxybenzene-3, 5-disulfonate confers protection against oxidative cell damage

1992 • 109 citations

Trolox protects rat hepatocytes against oxyradical damage and the ischemic rat liver from reperfusion injury

1991 • 107 citations

Impaired oxygen utilization. A new mechanism for the hepatotoxicity of ethanol in sub-human primates.

1989 • 107 citations

Cytosolic‐free Ca ²⁺ and cell killing in hepatoma 1c1c7 cells exposed to chemical anoxia

1989 • 102 citations

Oxygen dependence of oxidative stress

1990 • 99 citations

SIGNIFICANCE OF ARTERIAL KETONE BODY RATIO MEASUREMENT IN HUMAN LIVER TRANSPLANTATION

1990 • 88 citations

Calcium and pH in Anoxic and Toxic Injury

1990 • 82 citations

Oxypurinol as an inhibitor of xanthine oxidase-catalyzed production of superoxide radical

1988 • 74 citations

Homeostasis of Oxygen Supply in Liver and Kidney

1973 • 69 citations

Mitochondrial poisons cause depletion of reduced glutathione in isolated hepatocytes

1992 • 68 citations

Purine and pyrimidine metabolism in man

1993 • 68 citations

Release of reactive oxygen by hepatocytes on reoxygenation: three phases and role of mitochondria

1992 • 67 citations

NADH-Dependent reductive stress and ferritin-bound iron in allyl alcohol-induced lipid peroxidation in vivo: The protective effect of vitamin E

1992 • 63 citations

Prevention of Cyanide-Induced Cytotoxicity by Nutrients in Isolated Rat Hepatocytes

1994 • 54 citations

The involvement of reactive oxygen species in hypoxic injury to rat liver.

1988 • 52 citations

Effects of hypoxia and ethanol on xanthine oxidase of isolated rat hepatocytes: Conversion from D to O form and leakage from cells

1992 • 47 citations

Regulation of gluconeogenesis during exposure of young rats to hypoxic conditions

1971 • 45 citations

Oxygen radical production during ischemia-reperfusion in the isolated perfused rat liver as monitored by Luminol enhanced chemiluminescence

1991 • 44 citations

Enhancement of hypoxic liver damage by ethanol

1987 • 42 citations

Dependence of ethanol-induced redox shift on hepatic oxygen tensions prevailing in vivo

1985 • 40 citations

Late steady increase in cytosolic Ca2+ preceding hypoxic injury in hepatocytes

1992 • 33 citations

ATP synthase activity is required for fructose to protect cultured hepatocytes from the toxicity of cyanide

1993 • 33 citations

Enhancement of acute ethanol hepatotoxicity under conditions of low oxygen supply and ischemia/reperfusion

1989 • 31 citations

Cyanide‐Induced Injury to the Isolated Perfused Rat Liver

1988 • 28 citations

Effect of propylthiouracil on the ethanol-induced increase in liver oxygen consumption in awake rats

1993 • 28 citations

Effect of Antioxidants on Hypoxia/Reoxygenation‐Induced Injury in Isolated Perfused Rat Liver

1992 • 26 citations

Oxygen gradients: the problem of hypoxia

1987 • 25 citations

Protection by exogenous glutathione against hypoxic and cyanide-induced damage to isolated perfused rat livers

1990 • 13 citations

The effect of ethanol and cyanide on NAD/NADH2 ratios in rat liver

1969 • 11 citations

Cyanide-induced cytotoxicity to isolated hepatocytes

1990 • 8 citations

Respective Roles of Free Radicals and Energy Supply in Hypoxic Rat Liver Injury After Reoxygenation

1991 • 8 citations

Mechanisms of Protection of Hepatocytes at Anoxia and Reoxygenation by the Xanthine Oxidase Inhibitor Oxypurinol

1991 • 5 citations