Nuclear translocation of PKCζ during ischemia and its inhibition by wortmannin, an inhibitor of phosphatidylinositol 3‐kinase

Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C

1992 • 4,480 citations

The molecular heterogeneity of protein kinase C and its implications for cellular regulation

1988 • 4,243 citations

Oncogenes and signal transduction

1991 • 2,816 citations

Programmed Cell Death Induced by Ceramide

1993 • 1,779 citations

Reperfusion injury induces apoptosis in rabbit cardiomyocytes.

1994 • 1,431 citations

Activation of the zeta isozyme of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate.

1993 • 966 citations

Cloning and expression of multiple protein kinase C cDNAs

1986 • 683 citations

Mechanical stretch rapidly activates multiple signal transduction pathways in cardiac myocytes: potential involvement of an autocrine/paracrine mechanism.

1993 • 678 citations

Activation of protein kinase C family members by the novel polyphosphoinositides PtdIns-3,4-P2 and PtdIns-3,4,5-P3.

1994 • 553 citations

Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase

1995 • 520 citations

Protein kinase C zeta isoform is critical for kappa B-dependent promoter activation by sphingomyelinase.

1994 • 473 citations

Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathway.

1994 • 459 citations

Mechanical loading stimulates cell hypertrophy and specific gene expression in cultured rat cardiac myocytes. Possible role of protein kinase C activation.

1991 • 437 citations

Protein kinase C ζ isoform is critical for mitogenic signal transduction

1993 • 383 citations

Phosphoinositide kinases

1990 • 331 citations

Purification and characterization of the zeta isoform of protein kinase C from bovine kidney.

1992 • 283 citations

EGF or PDGF receptors activate atypical PKClambda through phosphatidylinositol 3-kinase.

1996 • 270 citations

Wortmannin and Its Structural Analogue Demethoxyviridin Inhibit Stimulated Phospholipase A2 Activity in Swiss 3T3 Cells

1995 • 252 citations

Protein kinase C isoform expression and regulation in the developing rat heart.

1994 • 245 citations

zeta PKC induces phosphorylation and inactivation of I kappa B-alpha in vitro.

1994 • 231 citations

Protection of the heart by ischaemic preconditioning: mechanisms and possibilities for pharmacological exploitation

1994 • 226 citations

Amiloride inhibits phorbol ester-stimulated Na+/H+ exchange and protein kinase C. An amiloride analog selectively inhibits Na+/H+ exchange.

1985 • 203 citations

Reperfusion of Rat Heart After Brief Ischemia Induces Proteolysis of Calspectin (Nonerythroid Spectrin or Fodrin) by Calpain

1995 • 170 citations

Transcriptional activation of the cardiac myosin light chain 2 and atrial natriuretic factor genes by protein kinase C in neonatal rat ventricular myocytes.

1992 • 170 citations

An enhancer core element mediates stimulation of the rat beta-myosin heavy chain promoter by an alpha 1-adrenergic agonist and activated beta-protein kinase C in hypertrophy of cardiac myocytes.

1994 • 146 citations

Structural and functional diversities of a family of signal transducing protein kinases, protein kinase C family; two distinct classes of PKC, conventional cPKC and novel nPKC

1991 • 134 citations

Protein kinase C phosphorylation of cardiac troponin I or troponin T inhibits Ca2(+)-stimulated actomyosin MgATPase activity.

1991 • 106 citations

Role of protein kinase C in the phosphorylation of cardiac myosin light chain 2

1993 • 94 citations

Myocardial structure in patients with exercise-induced ischemia.

1988 • 84 citations

Functional divergence of protein kinase C (PKC) family members. PKC gamma differs from PKC alpha and -beta II and nPKC epsilon in its competence to mediate-12-O-tetradecanoyl phorbol 13-acetate (TPA)-responsive transcriptional activation through a TPA-response element.

1993 • 76 citations

Dihydropyridine-sensitive calcium channels from skeletal muscle. II. Functional effects of differential phosphorylation of channel subunits.

1991 • 75 citations

Translocation of protein kinase C-α, δ and ϵ isoforms in ischemic rat heart

1996 • 75 citations

Modulation of cardiac Ca²⁺ channels in Xenopus oocytes by protein kinase C

1992 • 72 citations

Use of a PCR-based method to characterize protein kinase C isoform expression in cardiac cells

1993 • 70 citations

Effect of phorbol esters on contractile state and calcium flux in cultured chick heart cells

1987 • 69 citations

Calpain activity alters in rat myocardial subfractions after ischemia or reperfusion

1993 • 63 citations

Phorbol ester stimulates calcium sequestration in saponized human platelets.

1987 • 59 citations

Identification and characterization of protein kinase C zeta-immunoreactive proteins.

1994 • 51 citations

Protein kinase C activation aggravates hypoxic myocardial injury by stimulating Na+/H+ exchange

1988 • 39 citations

Comparison of the effects of phorbol 12-myristate 13-acetate and prostaglandin E1 on calcium regulation in human platelets

1988 • 23 citations

Rapid effects ofphorbol ester on platelet shape change, cytoskeleton and calcium transient

1986 • 22 citations

ω‐Oxidation of Lipoxin B₄ by Rat Liver

1994 • 14 citations

Protein kinase C phosphorylates a 15 kDa protein but not phospholamban in intact rat cardiac myocytes

1992 • 12 citations