FK506 and deoxyspergualin: experimental studies and clinical applications

Biology of Natural Killer Cells

1989 • 2,970 citations

Cyclophilin: A Specific Cytosolic Binding Protein for Cyclosporin A

1984 • 1,670 citations

A receptor for the immuno-suppressant FK506 is a cis–trans peptidyl-prolyl isomerase

1989 • 1,376 citations

FK-506, a novel immunosuppressant isolated from a Streptomyces. II. Immunosuppressive effect of FK-506 in vitro.

1987 • 1,209 citations

Peptidyl-prolyl cis-trans isomerase is the cyclosporin A-binding protein cyclophilin

1989 • 1,087 citations

FK 506 FOR LIVER, KIDNEY, AND PANCREAS TRANSPLANTATION

1989 • 1,043 citations

A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin

1989 • 1,010 citations

The immunosuppressant FK506 selectively inhibits expression of early T cell activation genes.

1989 • 667 citations

Novel immunosuppressive agent, FK506. In vitro effects on the cloned T cell activation.

1987 • 416 citations

Organ transplantation between widely disparate species.

1970 • 242 citations

Kidney Transplantation Under FK 506

1990 • 236 citations

Interaction of the Immunosuppressant Deoxyspergualin with a Member of the Hsp70 Family of Heat Shock Proteins

1992 • 232 citations

CADAVERIC SMALL BOWEL AND SMALL BOWEL-LIVER TRANSPLANTATION IN HUMANS 1,2

1992 • 173 citations

STUDIES OF THE INDUCTION AND MAINTENANCE OF LONG-TERM GRAFT ACCEPTANCE BY TREATMENT WITH FK506 IN HETEROTOPIC CARDIAC ALLOTRANSPLANTATION IN RATS

1987 • 169 citations

Immunosuppression of canine, monkey, and baboon allografts by FK 506: with special reference to synergism with other drugs and to tolerance induction.

1988 • 160 citations

STUDIES OF THE EFFECTS OF FK506 ON RENAL ALLOGRAFTING IN THE BEAGLE DOG

1987 • 137 citations

In vitro immunosuppressive effects of mycophenolic acid and an ester pro-drug, RS-61443.

1991 • 126 citations

A clinical trial of FK 506 as primary and rescue immunosuppression in cardiac transplantation.

1991 • 119 citations

THE USE OF FK-506 FOR SMALL INTESTINE ALLOTRANSPLANTATION INHIBITION OF ACUTE REJECTION AND PREVENTION OF FATAL GRAFT-VERSUS-HOST DISEASE

1990 • 118 citations

Randomized trial in primary liver transplantation under immunosuppression with FK 506 or cyclosporine.

1993 • 115 citations

EFFECT OF A NEW IMMUNOSUPPRESSIVE AGENT, FK506, ON HUMAN LYMPHOCYTE RESPONSES IN VITRO

1989 • 104 citations

PROLONGATION OF SKIN ALLOGRAFT SURVIVAL IN RATS BY A NOVEL IMMUNOSUPPRESSIVE AGENT, FK 506

1988 • 101 citations

MORPHOLOGICAL AND FUNCTIONAL CHANGES OF ISLETS OF LANGERHANS IN FK506-TREATED RATS

1992 • 100 citations

A NOVEL RESCUE DRUG, 15-DEOXYSPERGUALIN

1990 • 99 citations

AUGMENTATION OF RAT LIVER REGENERATION BY FK 506 COMPARED WITH CYCLOSPORIN

1989 • 97 citations

Selective suppression of an early step in human B cell activation by cyclosporin A.

1983 • 96 citations

STUDIES ON THE IMMUNOSUPPRESSIVE PROPERTIES OF CYCLOSPORIN A IN RATS RECEIVING RENAL ALLOGRAFTS

1980 • 93 citations

LIMB ALLOGRAFTS IN RATS IMMUNOSUPPRESSED WITH FK506

1989 • 89 citations

Cyclosporine: the agent and its actions.

1985 • 79 citations

SUPPRESSION OF ALLOGRAFT REJECTION WITH FK506

1990 • 79 citations

EVIDENCE THAT DEOXYSPERGUALIN PREVENTS SENSITIZATION AND FIRST-SET CARDIAC XENOGRAFT REJECTION IN RATS BY SUPPRESSION OF ANTIBODY FORMATION

1990 • 77 citations

THE PROTECTIVE EFFECT OF FK506 PRETREATMENT AGAINST RENAL ISCHEMIA/REPERFUSION INJURY IN RATS1

1992 • 77 citations

Effect of FK-506 on human mixed lymphocyte reaction in vitro.

1987 • 72 citations

Renal transplantation in baboons under FK 506.

1990 • 64 citations

Deoxyspergualin directly suppresses antibody formation in vivo and in vitro.

1990 • 63 citations

EFFECT OF A NEW IMMUNOSUPPRESSANT, 15-DEOXYSPERGUALIN, ON HETEROTOPIC RAT HEART TRANSPLANTATION, IN COMPARISON WITH CYCLOSPORINE

1987 • 61 citations

Mechanism of action of 15-deoxyspergualin. I. Suppressive effect on the induction of alloreactive secondary cytotoxic T lymphocytes in vivo and in vitro.

1989 • 58 citations

FK-506: Profile of an important new immunosuppressant

1990 • 58 citations

EFFECTS OF COMBINATION TREATMENT WITH FK506 AND CYCLOSPORINE ON SURVIVAL TIME AND VASCULAR CHANGES IN RENAL-ALLOGRAFT-RECIPIENT DOGS

1989 • 57 citations

Kidney transplantation under FK 506

1990 • 50 citations

Pathological studies in canine and baboon renal allograft recipients immunosuppressed with FK-506.

1987 • 49 citations

Blastogenic responses and the release of interleukins 1 and 2 by spleen cells obtained from rat skin allograft recipients administered with 15-deoxyspergualin.

1987 • 46 citations

IMMUNOSUPPRESSIVE ACTIVITY, LYMPHOCYTE SUBSET ANALYSIS, AND ACUTE TOXICITY OF FK-506 IN THE RAT. A COMPARATIVE AND COMBINATION STUDY WITH CYCLOSPORINE

1989 • 44 citations

THERAPEUTIC EFFECT OF 15-DEOXYSPERGUALIN ON ACUTE GRAFT REJECTION DETECTED BY P NUCLEAR MAGNETIC RESONANCE SPECTROGRAPHY, AND ITS EFFECT ON RAT HEART TRANSPLANTATION

1988 • 42 citations

15-DEOXYSPERGUALIN FOR INDUCTION OF GRAFT NONREACTIVITY AFTER CARDIAC AND RENAL ALLOTRANSPLANTATION IN PRIMATES

1990 • 42 citations

Induction of liver, heart, and multivisceral graft acceptance with a short course of FK 506.

1990 • 40 citations

Effects of a novel immunosuppressive agent, FK506, on human B cell activation

1990 • 39 citations

THE SALUTARY EFFECT OF FK506 IN ISCHEMIA-REPERFUSION INJURY OF THE CANINE LIVER

1992 • 38 citations

THE DISTINCT EFFECTS OF FK506 ON THE ACTIVATION, PROLIFERATION, AND DIFFERENTIATION OF HUMAN B LYMPHOCYTES

1992 • 33 citations

THE EFFECTS OF DEOXYSPERGUALIN ON LYMPHOCYTES AND MONOCYTES IN VIVO AND IN VITRO

1989 • 33 citations

FK506-INDUCED IMPAIRMENT OF GLUCOSE METABOLISM IN THE PRIMATE—STUDIES IN PANCREATIC TRANSPLANT RECIPIENTS AND IN NONTRANSPLANTED ANIMALS

1992 • 32 citations

EFFECT OF FK506 VERSUS CYCLOSPORINE ON HUMAN NATURAL AND ANTIBODY-DEPENDENT CYTOTOXICITY REACTIONS IN VITRO

1991 • 28 citations

THE IMMUNOSUPPRESSIVE ACTION OF FK 506

1990 • 24 citations

Deoxyspergualin induces tolerance in allogeneic kidney transplantation.

1987 • 24 citations

Reversal of acute rejection episodes by deoxyspergualin (NKT-01) in dogs receiving renal allografts.

1988 • 24 citations

Suppression of humoral immunity in dogs by 15-deoxyspergualin.

1987 • 23 citations

FK 506 rescue therapy in liver transplant recipients with drug-resistant rejection.

1991 • 23 citations

THE EFFECTS OF IMMUNOSUPPRESSIVE AGENTS ON IN VITRO PRODUCTION OF HUMAN IMMUNOGLOBULINS

1991 • 23 citations

FK-506 in experimental renal allografts.

1987 • 22 citations

THE USE OF FK-506 FOR SMALL INTESTINE ALLOTRANSPLANTATION

1990 • 22 citations

Spleen lymphocyte populations and expression of activation markers in rats treated with the potent new immunosuppressive agent FK-506.

1988 • 22 citations

Transplantation tolerance after short-term administration of 15-deoxyspergualin in orthotopic rat liver transplantation.

1987 • 22 citations

Prolongation of graft survival in allogeneic islet transplantation by (−) 15-deoxyspergualin in the rat

1987 • 21 citations

THE EFFECTS OF FK506 AND CYCLOSPORINE ON THE EXOCRINE FUNCTION OF THE RAT PANCREAS

1992 • 19 citations

15-Deoxyspergualin as an immunosuppressive agent in dogs.

1988 • 19 citations

FK 506 rescue therapy for resistant rejection episodes in liver transplant recipients.

1991 • 17 citations

Effect of splenectomy in combination with FK 506 and 15-deoxyspergualin on cardiac xenograft survival.

1991 • 16 citations

In vitro immunosuppressive effect of deoxymethylspergualin.

1990 • 16 citations

Prolongation of Graft Survival in Allogeneic Pancreas and Liver Transplantation by (–)15-Deoxyspergualin

1987 • 16 citations

FK 506 for rescue treatment of acute and chronic rejection in liver allograft recipients.

1991 • 16 citations

Effects of 15-deoxyspergualin on the induction of cytotoxic T lymphocytes and bone marrow suppression.

1989 • 14 citations

Use of FK 506 for treatment of chronic rejection after liver transplantation.

1991 • 14 citations

A new immunosuppressive agent, 15-deoxyspergualin, in dog renal allografting.

1989 • 13 citations

Experience with FK 506 in living related donor liver transplantation.

1991 • 13 citations

Deoxyspergualin

1993 • 12 citations

In vivo effects of deoxyspergualin (NKT-01) on lymphocyte activation in response to alloantigens.

1988 • 12 citations

Xenogeneic heart transplantation with 15-deoxyspergualin. Prolongation of graft survival.

1987 • 12 citations

Effect of 15-deoxyspergualin on graft-v-host disease in mice.

1987 • 11 citations

Effect of splenectomy and mono- or combination therapy with rapamycin, the morpholinoethyl ester of mycophenolic acid and deoxyspergualin on cardiac xenograft survival.

1991 • 11 citations

FK 506 rescue therapy for refractory acute rejection in five liver recipients.

1991 • 10 citations

In vivo31P nuclear magnetic resonance findings on heterotopically allografted hearts in rats treated with a novel immunosuppressant, FK 506

1990 • 10 citations

Effects of spergualin and 15-deoxyspergualin on the development of graft-versus-host disease in mice.

1987 • 10 citations

Deoxyspergualin, a potent antitumor agent: Further studies on the cytobiological mode of action.

1987 • 9 citations

Prominent prolongation of islet xenograft survival in combination therapy with FK 506 and 15-deoxyspergualin.

1991 • 8 citations

Prolongation Of Cardiac Xenograft Survival In A Hamster-To-Rat Combination By Recipient Treatment With Deoxymethylspergualin

1993 • 8 citations

Effect of FK 506 on B-cell responses.

1991 • 8 citations

Prolonged survival of cardiac allografts and xenografts in rat-to-rat and hamster-to-rat transplantation by treatment with deoxyspergualin.

1992 • 7 citations

15-Deoxyspergualin: a powerful rescue drug for rejection in canine kidney grafting.

1989 • 7 citations

Prolongation of cardiac xenograft survival in a hamster-to-rat combination by recipient treatment with deoxymethylspergualin.

1993 • 6 citations

Effective use of 15-deoxyspergualin in kidney transplantation.

1989 • 6 citations

EFFECT OF FK506 TREATMENT ON ALLOCYTOLYTIC T LYMPHOCYTE INDUCTION IN VIVO

1990 • 6 citations

Immunosuppressive effect of deoxyspergualin on acute renal allograft rejection in dogs.

1989 • 6 citations

Inhibition by deoxyspergualin of allo-reactive cytotoxic activity in mouse graft-versus-host disease.

1989 • 6 citations

PROLONGATION OF CARDIAC ALLOGRAFT SURVIVAL IN RATS BY RECIPIENT PRETREATMENT WITH DONOR SPLEEN CELLS AND 15-DEOXYSPERGUALIN

1989 • 5 citations

Effect of pharmacologic immunosuppression on donor heart survival in a closely related nonhuman primate xenograft model.

1990 • 5 citations

Remarkable recovery from rejection by treatment with deoxyspergualin and methylprednisolone on canine kidney allografts.

1991 • 3 citations

Suppression of humoral immunity in mice by spergualin.

1987 • 3 citations

15-Deoxyspergualin and primate heart transplantation.

1990 • 3 citations

The combined effect of deoxyspergualin and a donor-specific blood transfusion on canine kidney transplantation.

1990 • 2 citations