FK-506: Profile of an important new immunosuppressant

A receptor for the immuno-suppressant FK506 is a cis–trans peptidyl-prolyl isomerase

1989 • 1,376 citations

FK-506, a novel immunosuppressant isolated from a Streptomyces. I. Fermentation, isolation, and physico-chemical and biological characteristics.

1987 • 1,216 citations

FK-506, a novel immunosuppressant isolated from a Streptomyces. II. Immunosuppressive effect of FK-506 in vitro.

1987 • 1,209 citations

FK 506 FOR LIVER, KIDNEY, AND PANCREAS TRANSPLANTATION

1989 • 1,043 citations

A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin

1989 • 1,010 citations

The immunosuppressant FK506 selectively inhibits expression of early T cell activation genes.

1989 • 667 citations

Medicine and the Law

1987 • 541 citations

Inhibition of the immune response by rapamycin, a new antifungal antibiotic

1977 • 444 citations

Novel immunosuppressive agent, FK506. In vitro effects on the cloned T cell activation.

1987 • 416 citations

South Africa

1985 • 333 citations

FK-506 — How much potential?

1989 • 181 citations

STUDIES OF THE INDUCTION AND MAINTENANCE OF LONG-TERM GRAFT ACCEPTANCE BY TREATMENT WITH FK506 IN HETEROTOPIC CARDIAC ALLOTRANSPLANTATION IN RATS

1987 • 169 citations

Immunosuppression of canine, monkey, and baboon allografts by FK 506: with special reference to synergism with other drugs and to tolerance induction.

1988 • 160 citations

A highly sensitive method to assay FK-506 levels in plasma.

1987 • 149 citations

STUDIES OF THE EFFECTS OF FK506 ON RENAL ALLOGRAFTING IN THE BEAGLE DOG

1987 • 137 citations

FK-506, a potent novel immunosuppressive agent, binds to a cytosolic protein which is distinct from the cyclosporin A-binding protein, cyclophilin.

1989 • 137 citations

Effect of a new immunosuppressive agent, FK 506, on heterotopic cardiac allotransplantation in the rat.

1987 • 136 citations

Pharmacokinetics of FK 506: preclinical and clinical studies.

1990 • 124 citations

EFFECT OF A NEW IMMUNOSUPPRESSIVE AGENT, FK506, ON HUMAN LYMPHOCYTE RESPONSES IN VITRO

1989 • 104 citations

PROLONGATION OF SKIN ALLOGRAFT SURVIVAL IN RATS BY A NOVEL IMMUNOSUPPRESSIVE AGENT, FK 506

1988 • 101 citations

Physicochemical properties of FK-506, a novel immunosuppressant isolated from Streptomyces tsukubaensis.

1987 • 89 citations

Effects of a new immunosuppressive agent, FK506, on experimental autoimmune uveoretinitis in rats.

1988 • 80 citations

Immunosuppressive effect of FK506 on collagen-induced arthritis in rats

1988 • 72 citations

Heterotopic heart transplantation in the rat receiving FK-506 alone or with cyclosporine.

1987 • 71 citations

Inhibition of T-lymphocyte activation by the immunosuppressive drug FK-506.

1989 • 69 citations

Effect of FK-506, a novel immunosuppressive drug on murine systemic lupus erythematosus

1989 • 69 citations

Renal transplantation in baboons under FK 506.

1990 • 64 citations

FK-506 enters the clinic

1990 • 64 citations

The side effects of FK 506 in humans.

1990 • 63 citations

Toxicology of FK-506 in the Lewis rat.

1987 • 63 citations

EFFECTS OF COMBINATION TREATMENT WITH FK506 AND CYCLOSPORINE ON SURVIVAL TIME AND VASCULAR CHANGES IN RENAL-ALLOGRAFT-RECIPIENT DOGS

1989 • 57 citations

Canine kidney transplantation with FK-506 alone or in combination with cyclosporine and steroids.

1987 • 56 citations

The oral dosage form of FK-506.

1987 • 51 citations

Biopharmaceutical aspects of FK-506.

1987 • 49 citations

IMMUNOSUPPRESSIVE ACTIVITY, LYMPHOCYTE SUBSET ANALYSIS, AND ACUTE TOXICITY OF FK-506 IN THE RAT. A COMPARATIVE AND COMBINATION STUDY WITH CYCLOSPORINE

1989 • 44 citations

FK-506 - A POTENTIAL BREAKTHROUGH IN IMMUNOSUPPRESSION

1987 • 40 citations

Kidney transplantation in the dog receiving FK-506.

1987 • 39 citations

The Influence of FK‐506 and Low‐Concentration Ciclosporin on Human Lymphocyte Activation Antigen Expression and Blastogenesis: a Flow Cytometric Analysis

1990 • 34 citations

Inhibition of murine B-lymphocyte proliferation by the novel immunosuppressive drug FK-506.

1989 • 33 citations

FK506

1988 • 32 citations

PROLONGATION OF CARDIAC XENOGRAFT SURVIVAL IN RATS TREATED WITH 15-DEOXYSPERGUALIN ALONE AND IN COMBINATION WITH FK506

1988 • 29 citations

Suppression of corneal graft rejection in rabbits by a new immunosuppressive agent, FK-506.

1989 • 29 citations

Effects of FK-506 on collagen arthritis in mice.

1989 • 25 citations

Observations about FK-506 in primates.

1987 • 23 citations

FK 506 inhibition of cyclosporine metabolism by human liver microsomes.

1991 • 21 citations

Heterotopic heart transplantation in the rat receiving FK-506.

1987 • 20 citations

Cyclosporin. Mode of Action and Clinical Application

1991 • 20 citations

Immunosuppressive activity of FK-506 in rats: flow cytometric analysis of lymphocyte populations in blood, spleen and thymus during treatment and following drug withdrawal

1990 • 19 citations

Histopathologic studies in renal transplant recipient dogs receiving treatment with FK-506.

1987 • 19 citations

A cost comparison of liver transplantation with FK 506 or CyA as the primary immunosuppressive agent.

1990 • 16 citations

Effect of FK-506 and cyclosporine on human lymphocyte responses in vitro.

1989 • 14 citations

Orthotopic liver transplantation in rats receiving FK506.

1989 • 13 citations

Effects of FK-506 on xenotransplantation of the heart and skin in a mouse-rat combination.

1987 • 12 citations

Toxicity of FK-506 in Human Fetal Pancreas

1989 • 11 citations

FK506—ITS INFLUENCE ON ANTI-CLASS 1 MHC ALLOANTIBODY RESPONSES TO BLOOD TRANSFUSIONS

1990 • 11 citations

Effect of a novel immunosuppressive agent, FK506, on mitogen-induced inositol phospholipid degradation in rat thymocytes.

1989 • 8 citations

Immunosuppressive activity, T-cell subset analysis, and acute toxicity of FK-506 in rats.

1989 • 7 citations

EFFECT OF A NOVEL IMMUNOSUPPRESSIVE AGENT, FK506, ON MITOGEN-INDUCED INOSITOL PHOSPHOLIPID DEGRADATION IN RAT THYMOCYTES

1989 • 6 citations

Effects of a novel immunosuppressive agent, FK-506, on islet allograft survival in the rat.

1989 • 5 citations

Pathological effects of cyclosporin A in clinical practice

1989 • 5 citations

Clinical transplantation : current practice and future prospects

1987 • 3 citations

Rejection, the Immune Response, and the Influence of Cyclosporin A

1987 • 1 citations