Structure-function studies of human aromatase

High-resolution crystal structure of cytochrome P450cam

1987 • 1,396 citations

The 2.6-A crystal structure of Pseudomonas putida cytochrome P-450.

1985 • 815 citations

Utilization of Oxygen and Reduced Nicotinamide Adenine Dinucleotide Phosphate by Human Placental Microsomes during Aromatization of Androstenedione

1974 • 693 citations

Aromatization of Androstenedione by Human Adipose Tissue Stromal Cells in Monolayer Culture*

1981 • 395 citations

Uncoupling of the cytochrome P-450cam monooxygenase reaction by a single mutation, threonine-252 to alanine or valine: possible role of the hydroxy amino acid in oxygen activation.

1989 • 364 citations

Isolation of a full-length cDNA insert encoding human aromatase system cytochrome P-450 and its expression in nonsteroidogenic cells.

1988 • 302 citations

The importance of local synthesis of estrogen within the breast

1987 • 280 citations

A conserved residue of cytochrome P-450 is involved in heme-oxygen stability and activation

1989 • 274 citations

Aromatase Cytochrome P450 in Rat Ovarian Granulosa Cells before and after Luteinization: Adenosine 3′,5′-Monophosphate-Dependent and Independent Regulation. Cloning and sequencing of rat aromatase cDNA and 5′ genomic DNA

1990 • 257 citations

Human Aromatase: cDNA Cloning, Southern Blot Analysis, and Assignment of the Gene to Chromosome 15

1988 • 227 citations

Crystal structure of the cytochrome P-450CAM active site mutant Thr252Ala

1991 • 205 citations

Stable expression of human aromatase complementary DNA in mammalian cells: a useful system for aromatase inhibitor screening.

1990 • 205 citations

Cloning of a complete cDNA encoding human aromatase : Immunochemical identification and sequence analysis

1988 • 164 citations

Cloning and sequence analysis of the cDNA encoding P-450 aromatase (P450arom) from a rainbow trout (Oncorhynchus mykiss) ovary; relationship between the amount of P450arom mRNA and the production of oestradiol-17β in the ovary

1992 • 162 citations

The expression of a functional cDNA encoding the chicken cytochrome P-450arom (aromatase) that catalyzes the formation of estrogen from androgen.

1988 • 158 citations

Resistance of the Ovary to Blockade of Aromatization with Aminoglutethimide*

1980 • 129 citations

Isolation of a full-length cDNA encoding mouse aromatase P450

1991 • 121 citations

Structure-function relationships of human aromatase cytochrome P-450 using molecular modeling and site-directed mutagenesis

1991 • 113 citations

Inhibition of Aromatase With CGS 16949A in Postmenopausal Women*

1989 • 99 citations

Techniques in Protein Chemistry III

1993 • 90 citations

An Enzyme-Linked Immunosorbent Assay for Quantitation of Aromatase Cytochrome P-450*

1989 • 82 citations

4-Hydroxyandrostenedione treatment for postmenopausal patients with advanced breast cancer

1987 • 79 citations

A site-directed mutagenesis study of human placental aromatase.

1992 • 72 citations

Amino terminal sequence analysis of human placenta aromatase

1986 • 56 citations

Expression of Human Placental Aromatase inSaccharomyces cerevisiae

1989 • 55 citations

Kinetic properties of aromatase mutants Pro308Phe, Asp309Asn, and Asp309Ala and their interactions with aromatase inhibitors

1992 • 54 citations

Alternative usage of different poly(A) addition signals for two major species of mRNA encoding human aromatase P‐450

1989 • 52 citations

Structure-function studies of human aromatase by site-directed mutagenesis: kinetic properties of mutants Pro-308----Phe, Tyr-361----Phe, Tyr-361----Leu, and Phe-406----Arg.

1991 • 49 citations

Estrogen synthetase (aromatase). The cytochrome P-450 component of the human placental enzyme is a glycoprotein

1991 • 35 citations

Expression of rat liver NAD(P)H:quinone-acceptor oxidoreductase in Escherichia coli and mutagenesis in vitro at Arg-177

1992 • 27 citations

Catalytic efficiency of expressed aromatase following site-directed mutagenesis

1993 • 20 citations

Applications of Liquid Chromatography-Electrospray Mass Spectrometry (LC-ES/MS)

1992 • 7 citations

Electrospray Mass Spectral Analysis of the (N)-Arylazido-β-Alanyl NAD+ Modified Bovine Heart Mitochondrial NADH Dehydrogenase

1994 • 3 citations