Expression of Neuronal Traits in Pancreatic Beta Cells

Genomic sequencing.

1984 • 8,343 citations

Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.

1976 • 5,526 citations

A rapid micrqpreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells

1991 • 2,362 citations

Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase

1990 • 1,955 citations

High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor

1991 • 1,232 citations

Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines.

1992 • 1,128 citations

The Neuron-Restrictive Silencer Factor (NRSF): A Coordinate Repressor of Multiple Neuron-Specific Genes

1995 • 1,078 citations

REST: A mammalian silencer protein that restricts sodium channel gene expression to neurons

1995 • 1,078 citations

Conversion of Xenopus Ectoderm into Neurons by NeuroD, a Basic Helix-Loop-Helix Protein

1995 • 1,028 citations

Insulin gene enhancer binding protein Isl-1 is a member of a novel class of proteins containing both a homeo-and a Cys–His domain

1990 • 684 citations

Type-I Diabetes: A Chronic Autoimmune Disease of Human, Mouse, and Rat

1990 • 650 citations

Tissue-specific regulation of the insulin gene by a novel basic helix-loop-helix transcription factor.

1995 • 601 citations

Beta-cell lines derived from transgenic mice expressing a hybrid insulin gene-oncogene.

1988 • 523 citations

Continuous, clonal, insulin- and somatostatin-secreting cell lines established from a transplantable rat islet cell tumor.

1980 • 496 citations

Hybrid insulin genes reveal a developmental lineage for pancreatic endocrine cells and imply a relationship with neurons

1988 • 455 citations

Pathways to Regulated Exocytosis in Neurons

1990 • 454 citations

A common silencer element in the SCG10 and type II Na+ channel genes binds a factor present in nonneuronal cells but not in neuronal cells

1992 • 420 citations

The homeodomain LIM protein Isl-1 is expressed in subsets of neurons and endocrine cells in the adult rat

1991 • 338 citations

Silencing the type II sodium channel gene: A model for neural-specific gene regulation

1992 • 315 citations

Primary structure and expression of β2: A novel subunit of neuronal nicotinic acetylcholine receptors

1988 • 301 citations

On the origin of pancreatic endocrine cells

1988 • 195 citations

Glucagon gene regulatory region directs oncoprotein expression to neurons and pancreatic a cells

1988 • 161 citations

The induction of a neural-specific gene, SCG10, by nerve growth factor in PC12 cells is transcriptional, protein synthesis dependent, and glucocorticoid inhibitable

1988 • 148 citations

Neuron-specific Gene Expression of Synapsin I

1996 • 141 citations

Cell lineage analysis of pancreatic islet cell development: Glucagon and insulin cells arise from catecholaminergic precursors present in the pancreatic duct

1987 • 136 citations

Novel Insulin Promoter- and Enhancer-Binding Proteins That Discriminate between Pancreatic α- and β-Cells

1991 • 116 citations

Functional neuronal ionotropic glutamate receptors are expressed in the non-neuronal cell line MIN6.

1994 • 113 citations

Pax-QNR/Pax-6, a paired box- and homeobox-containing gene expressed in neurons, is also expressed in pancreatic endocrine cells.

1994 • 113 citations

Nerve growth factor induces neuron-like differentiation of an insulin-secreting pancreatic beta cell line.

1993 • 106 citations

Ontogenetic patterns of thyrotropin-releasing hormone-like material in rat hypothalamus, pancreas, and retina: selective effect of light deprivation.

1980 • 93 citations

Expression of p75^NGFR trkA, and trkB mRNA in rat C6 glioma and type I astrocyte cultures

1992 • 89 citations

A molecular inventory of human pancreatic islets: sequence analysis of 1000 cDNA clones

1993 • 74 citations

Expression of Functional Nerve Growth Factor Receptors in Pancreatic β-cell Lines and Fetal Rat Islets in Primary Culture

1993 • 56 citations

Insulin cells of pancreas extend neurites but do not arise from the neuroectoderm

1990 • 50 citations

Expression of the trans-active factors that stimulate insulin control element-mediated activity appear to precede insulin gene transcription.

1994 • 37 citations

Expression and regulation of growth hormone (GH) and prolactin (PRL) receptors in a rat insulin producing cell line (INS-1)

1995 • 37 citations

Neurotrophin-3 Increases Intracellular Calcium in a Rat Insulin-secreting Cell Line through Its Action on a Functional TrkC Receptor

1996 • 27 citations

Persistence of Peptidylglycine α-Amidating Monooxygenase Activity and Elevated Thyrotropin- Releasing Hormone Concentrations in Fetal Rat Islets in Culture*

1988 • 24 citations

Human, Rodent, and Canine Pancreatic β-cells Express a Sodium Channel α1-Subunit Related to a Fetal Brain Isoform

1993 • 24 citations

A Subtractive Cloning Approach to the Identification of mRNAs Specifically Expressed in Pancreatic β-cells

1996 • 22 citations

Immunohistochemical colocalization of insulin, aromatic L-amino acid decarboxylase and dopamine beta-hydroxylase in islet B cells of chicken pancreas

1991 • 17 citations

Molecular cloning of a group of mouse pancreatic islet beta-cell-related genes by random cDNA sequencing

1995 • 9 citations

Dexamethasone Regulates the Expression of Neuronal Properties of a Rat Insulinoma Cell Line

1995 • 9 citations