Changes in Leptin Levels during Lactation: Implications for Lactational Hyperphagia and Anovulation

Positional cloning of the mouse obese gene and its human homologue

1994 • 12,975 citations

Weight-Reducing Effects of the Plasma Protein Encoded by the obese Gene

1995 • 4,457 citations

Effects of the obese Gene Product on Body Weight Regulation in ob / ob Mice

1995 • 4,057 citations

Recombinant Mouse OB Protein: Evidence for a Peripheral Signal Linking Adiposity and Central Neural Networks

1995 • 3,302 citations

Role of leptin in the neuroendocrine response to fasting

1996 • 3,106 citations

Leptin levels reflect body lipid content in mice: Evidence for diet-induced resistance to leptin action

1995 • 1,630 citations

The role of neuropeptide Y in the antiobesity action of the obese gene product

1995 • 1,521 citations

Transient increase in obese gene expression after food intake or insulin administration

1995 • 1,102 citations

Leptin is a metabolic signal to the reproductive system.

1996 • 1,037 citations

Early Onset of Reproductive Function in Normal Female Mice Treated with Leptin

1997 • 844 citations

Leptin Increases Hypothalamic Pro-opiomelanocortin mRNA Expression in the Rostral Arcuate Nucleus

1997 • 837 citations

Leptin Receptor Immunoreactivity in Chemically Defined Target Neurons of the Hypothalamus

1998 • 753 citations

Acute and Chronic Effect of Insulin on Leptin Production in Humans: Studies In Vivo and In Vitro

1996 • 716 citations

Relation between plasma leptin concentration and body fat, gender, diet, age, and metabolic covariates.

1996 • 641 citations

Leptin Is a Metabolic Gate for the Onset of Puberty in the Female Rat

1997 • 506 citations

Sexual Dimorphism in Plasma Leptin Concentration

1997 • 497 citations

Leptin Treatment Rescues the Sterility of Genetically Obese ob/ob Males*

1997 • 456 citations

Serum Prolactin Levels in Rats During Different Reproductive States

1970 • 403 citations

Activation of β3 Adrenergic Receptors Suppresses Leptin Expression and Mediates a Leptin-Independent Inhibition of Food Intake in Mice

1996 • 315 citations

Evidence for GnRH Regulation by Leptin: Leptin Administration Prevents Reduced Pulsatile LH Secretion during Fasting

1998 • 314 citations

Relation between plasma leptin concentration and body fat, gender, diet, age, and metabolic covariates

1996 • 305 citations

A Leptin Dose-Response Study in Obese (ob/ob) and Lean (+/?) Mice

1998 • 296 citations

The ob Gene and Insulin: A Relationship Leading to Clues to the Understanding of Obesity

1995 • 275 citations

Evidence Suggesting That Galanin (GAL), Melanin-Concentrating Hormone (MCH), Neurotensin (NT), Proopiomelanocortin (POMC) and Neuropeptide Y (NPY) Are Targets of Leptin Signaling in the Hypothalamus

1998 • 241 citations

Central Administration of Leptin to Ovariectomized Ewes Inhibits Food Intake without Affecting the Secretion of Hormones from the Pituitary Gland: Evidence for a Dissociation of Effects on Appetite and Neuroendocrine Function

1999 • 228 citations

Short-term dexamethasone treatment increases plasma leptin independently of changes in insulin sensitivity in healthy women.

1996 • 203 citations

Leptin Is Present in Human Milk and Is Related to Maternal Plasma Leptin Concentration and Adiposity

1997 • 201 citations

Lactation alters neuropeptide-Y and proopiomelanocortin gene expression in the arcuate nucleus of the rat.

1993 • 174 citations

Influence of Endogenous Leptin Tone on the Estrous Cycle and Luteinizing Hormone Pulsatility in Female Rats

1997 • 158 citations

Inhibition of Gonadotropin Secretion During Lactation in the Rat: Relative Contribution of Suckling and Ovarian Steroids1

1977 • 157 citations

Central Administration of Leptin to Ovariectomized Ewes Inhibits Food Intake without Affecting the Secretion of Hormones from the Pituitary Gland: Evidence for a Dissociation of Effects on Appetite and Neuroendocrine Function*

1999 • 151 citations

Leptin Gene Expression Increases With Age Independent of Increasing Adiposity in Rats

1997 • 149 citations

Leptin Is Not Necessary for Gestation and Parturition But Regulates Maternal Nutrition via a Leptin Resistance State

1998 • 141 citations

Chronic Administration of Leptin into the Lateral Ventricle Induces Sexual Maturation in Severely Food‐restricted Female Rats

1998 • 139 citations

PLASMA PROGESTERONE CONCENTRATIONS DURING PREGNANCY AND LACTATION IN THE RAT

1967 • 131 citations

The utilization of protein and energy during lactation in the rat, with particular regard to the use of fat accumulated in pregnancy

1982 • 128 citations

Concentrations of leptin in the serum of pregnant, lactating, and cycling rats and of leptin messenger ribonucleic acid in rat placental tissue

1998 • 125 citations

Increase of Mouse Leptin Production by Adipose Tissue after Midpregnancy: Gestational Profile of Serum Leptin Concentration

1997 • 108 citations

Leptin Indirectly Affects Estrous Cycles by Increasing Metabolic Fuel Oxidation

1998 • 105 citations

Disruption of the Relationship between Fat Content and Leptin Levels with Aging in Humans¹

1998 • 102 citations

Influence of cycling, pregnancy, labor, and suckling on corticosterone-ACTH levels

1969 • 101 citations

Endocrine control of metabolic adaptation during lactation

1989 • 100 citations

The Suppression of Pulsatile Luteinizing Hormone Secretion during Lactation in the Rat*

1984 • 97 citations

THE CORPUS LUTEUM-PITUITARY RELATIONSHIP: THE ASSOCIATION BETWEEN THE CAUSE OF LUTEOTRO- PHIN SECRETION AND THE CAUSE OF FOLLICULAR QUIESCENCE DURING LACTATION; THE BASIS FOR A TENTATIVE THEORY OF THE CORPUS LUTEUM-PITUITARY RELATIONSHIP IN THE RAT¹

1960 • 95 citations

Regulation of circulating leptin in humans

1997 • 94 citations

Control of food intake in the lactating rat: Role of suckling and hormones

1976 • 89 citations

Disruption of the Relationship between Fat Content and Leptin Levels with Aging in Humans

1998 • 80 citations

Increased neuropeptide Y concentrations in specific hypothalamic regions of lactating rats: Possible relationship ot hyperphagia and adaptive changes in energy balance

1994 • 73 citations

Gonadotropin Levels in Lactating Rats: Effect of Ovariectomy12

1973 • 65 citations

Energetic limits on reproduction: Maternal food intake

1983 • 58 citations

THE INFLUENCE OF SUCKLING ON FOOD INTAKE AND GROWTH OF ADULT FEMALE RATS

1954 • 57 citations

Mechanisms of Suppression of Ovarian Follicular Development During Lactation in the Rat

1982 • 55 citations

REPRODUCTION DURING LACTATION

1978 • 50 citations

Prolactin in the Postpartum Rat: Synthesis and Release in the Absence of Suckling Stimulation

1969 • 49 citations

Serum Leptin Levels Do Not Rise during Pregnancy in Age-Matched Rats

1998 • 40 citations

Effect of acute food deprivation on lactational infertility in rats is reduced by leptin administration

1998 • 39 citations

Brown adipose tissue thermogenesis and the energetics of pregnancy and lactation in rodents

1985 • 39 citations

CONCERNING THE MECHANISM OF DIESTRUM DURING LACTATION IN THE ALBINO RAT

1947 • 30 citations

Suppression of LH secretion in food-restricted lactating females: effects of ovariectomy and bromocryptine treatment

1995 • 29 citations

The Contribution of Changes in Milk Delivery to the Prolongation of Lactational Infertility Induced by Food Restriction or Increased Litter Size

1998 • 21 citations

Factors influencing the self-selection of calcium in lactating rats

1989 • 15 citations

The Endogenous Opioids Do Not Mediate the Suckling-Induced Suppression of LH Secretion in Lactating Rats.

1992 • 9 citations