Active site comparisons highlight structural similarities between myosin and other P-loop proteins

Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold.

1982 • 5,284 citations

The GTPase superfamily: conserved structure and molecular mechanism

1991 • 3,365 citations

Structure at 2.8 Â resolution of F1-ATPase from bovine heart mitochondria

1994 • 2,954 citations

The P-loop — a common motif in ATP- and GTP-binding proteins

1990 • 2,029 citations

Three-dimensional structure of myosin subfragment-1: a molecular motor

1993 • 2,027 citations

Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis.

1990 • 1,077 citations

Molecular Switch for Signal Transduction: Structural Differences Between Active and Inactive Forms of Protooncogenic ras Proteins

1990 • 1,037 citations

Structure of the guanine-nucleotide-binding domain of the Ha-ras oncogene product p21 in the triphosphate conformation

1989 • 881 citations

Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis

1994 • 823 citations

The 2.2 Å crystal structure of transducin-α complexed with GTPγS

1993 • 788 citations

The structure of the E. coli recA protein monomer and polymer

1992 • 738 citations

The Protein Data Bank

1977 • 716 citations

Structural determinants for activation of the α-subunit of a heterotrimeric G protein

1994 • 636 citations

Structure of the recA protein–ADP complex

1992 • 617 citations

X-ray Structures of the Myosin Motor Domain of Dictyostelium discoideum Complexed with MgADP.cntdot.BeFx and MgADP.cntdot.AlF4-

1995 • 610 citations

GTPase mechanism of Gproteins from the 1.7-Å crystal structure of transducin α - GDP AIF−4

1994 • 564 citations

ATP-binding site of adenylate kinase: mechanistic implications of its homology with ras-encoded p21, F1-ATPase, and other nucleotide-binding proteins.

1986 • 538 citations

Crystal structure of active elongation factor Tu reveals major domain rearrangements

1993 • 533 citations

Structure of the complex between adenylate kinase from Escherichia coli and the inhibitor Ap5A refined at 1.9 Å resolution

1992 • 502 citations

The crystal structure of elongation factor EF-Tu from Thermus aquaticus in the GTP conformation

1993 • 399 citations

The crystal structure of elongation factor G complexed with GDP, at 2.7 A resolution.

1994 • 377 citations

Three-dimensional structure of the ribosomal translocase: elongation factor G from Thermus thermophilus.

1994 • 367 citations

Sequence and structure of yeast phosphoglycerate kinase.

1982 • 364 citations

Tertiary and Quaternary Structural Changes in G _iα1 Induced by GTP Hydrolysis

1995 • 294 citations

Substrate-assisted catalysis as a mechanism for GTP hydrolysis of p21ras and other GTP-binding proteins

1995 • 273 citations

Mutational and kinetic analyses of the GTPase-activating protein (GAP)-p21 interaction: the C-terminal domain of GAP is not sufficient for full activity.

1992 • 268 citations

Refined structure of porcine cytosolic adenylate kinase at 2.1 Å resolution

1988 • 243 citations

The limited tryptic cleavage of chymotryptic S-1 : An approach to the characterization of the actin site in myosin heads

1979 • 206 citations

The closed conformation of a highly flexible protein: The structure of E. coli adenylate kinase with bound AMP and AMPPNP

1994 • 141 citations

Probing the Structure and Mechanism of Ras Protein with an Expanded Genetic Code

1993 • 130 citations

Refined structure of the complex between guanylate kinase and its substrate GMP at 2·0 Å resolution

1992 • 123 citations

Why have mutagenesis studies not located the general base in ras p21

1994 • 122 citations

The substructure of heavy meromyosin. The effect of Ca2+ and Mg2+ on the tryptic fragmentation of heavy meromyosin.

1975 • 119 citations

Transient phase of adenosine triphosphate hydrolysis by myosin, heavy meromyosin, and subfragment 1

1977 • 102 citations

Structural studies of myosin:nucleotide complexes: a revised model for the molecular basis of muscle contraction.

1995 • 95 citations

The Mechanism of Guanosine Nucleotide Hydrolysis by p21 c-Ha-ras

1989 • 91 citations

X-ray Structure of the Magnesium(II)-Pyrophosphate Complex of the Truncated Head of Dictyostelium discoideum Myosin to 2.7 .ANG. Resolution

1995 • 85 citations

The Structure of Uridylate Kinase with Its Substrates, Showing the Transition State Geometry

1994 • 79 citations

Nucleotide sequence of Acinetobacter baumannii aphA‐6 gene: evolutionary and functional implications of sequence homologies with nucleotide‐binding proteins, kinases and other aminoglycoside‐modifying enzymes

1988 • 78 citations

Formation of the stable myosin-ADP-aluminum fluoride and myosin-ADP-beryllium fluoride complexes and their analysis using 19F NMR.

1993 • 74 citations

Structure of the ADP complex of the 3-phosphoglycerate kinase from Bacillus stearothermophilus at 1.65 Å

1994 • 70 citations

The mechanism of ATP hydrolysis catalyzed by myosin and actomyosin, using rapid reaction techniques to study oxygen exchange.

1981 • 69 citations

The use of differing nucleotides to investigate cross-bridge kinetics

1993 • 62 citations

The equivalence of phosphate oxygens for exchange and the hydrolysis characteristics revealed by the distribution of [18O]Pi species formed by myosin and actomyosin ATPase.

1980 • 61 citations

Three-dimensional structure of the complex between the mitochondrial matrix adenylate kinase and its substrate AMP

1990 • 51 citations

Observation of multiple myosin subfragment 1-ADP-fluoroberyllate complexes by fluorine-19 NMR spectroscopy

1993 • 35 citations

Primary structural constraints of P-loop of mitochondrial F1-ATPase from yeast

1994 • 32 citations

Analysis of phosphorus-31 NMR spectra of enzyme-bound reactants and products of adenylate kinase using density matrix theory of chemical exchange

1984 • 18 citations

Investigating the Structural Determinants of the p21-like Triphosphate and Mg2+Binding Site

1995 • 17 citations

Analysis of positional isotope exchange in ATP by cleavage of the .beta.P-O.gamma.P bond. Demonstration of negligible positional isotope exchange by myosin

1987 • 16 citations

Amino acid substitutions within the analogous nucleotide binding loop (P-loop) of aminoglycoside 3'-phosphotransferase-II

1994 • 11 citations

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