Transduction of cytotoxic signals in natural killer cells: a general model of fine tuning between activatory and inhibitory pathways in lymphocytes

Biologic basis for interleukin-1 in disease

1996 • 4,324 citations

Biology of Natural Killer Cells

1989 • 2,970 citations

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

1995 • 2,842 citations

Immunosuppression by Glucocorticoids: Inhibition of NF-κB Activity Through Induction of IκB Synthesis

1995 • 2,386 citations

Signal transduction by lymphocyte antigen receptors

1994 • 2,145 citations

Selective rejection of H–2-deficient lymphoma variants suggests alternative immune defence strategy

1986 • 2,102 citations

JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin

1993 • 1,223 citations

FcR γ chain deletion results in pleiotrophic effector cell defects

1994 • 967 citations

Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals

1995 • 956 citations

Catalytic specificity of protein-tyrosine kinases is critical for selective signalling

1995 • 929 citations

CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells.

1996 • 917 citations

RECEPTORS FOR HLA CLASS-I MOLECULES IN HUMAN NATURAL KILLER CELLS

1996 • 871 citations

MHC class I alloantigen specificity of Ly-49+ IL-2-activated natural killer cells

1992 • 805 citations

LAG-3, a novel lymphocyte activation gene closely related to CD4.

1990 • 802 citations

CTLA-4 ligation blocks CD28-dependent T cell activation.

1996 • 787 citations

The cytoplasmic domain of the T cell receptor ζ chain is sufficient to couple to receptor-associated signal transduction pathways

1991 • 782 citations

Role of the inositol phosphatase SHIP in negative regulation of the immune system by the receptor FeγRIIB

1996 • 770 citations

Cloning of Immunoglobulin-Superfamily Members Associated with HLA-C and HLA-B Recognition by Human Natural Killer Cells

1995 • 735 citations

The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase.

1996 • 636 citations

Recruitment of Tyrosine Phosphatase HCP by the Killer Cell Inhibitory Receptor

1996 • 625 citations

Partial T cell signaling: Altered phospho-? and lack of zap70 recruitment in APL-induced T cell anergy

1994 • 608 citations

DNAM-1, A Novel Adhesion Molecule Involved in the Cytolytic Function of T Lymphocytes

1996 • 599 citations

Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains

1995 • 575 citations

EGL-10 Regulates G Protein Signaling in the C. elegans Nervous System and Shares a Conserved Domain with Many Mammalian Proteins

1996 • 573 citations

A Role in B Cell Activation for CD22 and the Protein Tyrosine Phosphatase SHP

1995 • 551 citations

P58 molecules as putative receptors for major histocompatibility complex (MHC) class I molecules in human natural killer (NK) cells. Anti-p58 antibodies reconstitute lysis of MHC class I-protected cells in NK clones displaying different specificities.

1993 • 537 citations

Recruitment and Activation of PTP1C in Negative Regulation of Antigen Receptor Signaling by FcγRIIB1

1995 • 535 citations

New perspectives of C1328-137-mediated T cell costimulation

1995 • 526 citations

ζ Phosphorylation Without ZAP-70 Activation Induced by TCR Antagonists or Partial Agonists

1995 • 510 citations

Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family

1996 • 470 citations

Tyrosine phosphatase CD45 is essential for coupling T-cell antigen receptor to the phosphatidyl inositol pathway

1990 • 466 citations

The Ly-49 and NKR-P1 Gene Families Encoding Lectin-Like Receptors on Natural Killer Cells: The NK Gene Complex

1993 • 465 citations

Cytoplasmic Domain Heterogeneity and Functions of IgG Fc Receptors in B Lymphocytes

1992 • 462 citations

The same tyrosine-based inhibition motif, in the intra-cytoplasmic domain of FcγRIIB, regulates negatively BCR-, TCR-, and FcR-dependent cell activation

1995 • 448 citations

Existence of both inhibitory (p58) and activatory (p50) receptors for HLA-C molecules in human natural killer cells.

1995 • 446 citations

G protein—coupled receptor kinases

1993 • 434 citations

p150Ship, a signal transduction molecule with inositol polyphosphate-5-phosphatase activity.

1996 • 429 citations

Truncated erythropoietin receptor causes dominantly inherited benign human erythrocytosis.

1993 • 404 citations

A protein-tyrosine phosphatase with sequence similarity to the SH2 domain of the protein-tyrosine kinases

1991 • 401 citations

Cellular immunity to HIV activated by CD4 fused to T cell or Fc receptor polypeptides

1991 • 391 citations

Direct Regulation of ZAP-70 by SHP-1 in T Cell Antigen Receptor Signaling

1996 • 390 citations

Identification of four subsets of human CD3-CD16+ natural killer (NK) cells by the expression of clonally distributed functional surface molecules: correlation between subset assignment of NK clones and ability to mediate specific alloantigen recognition.

1990 • 388 citations

Interaction of Fc receptor (CD16) ligands induces transcription of interleukin 2 receptor (CD25) and lymphokine genes and expression of their products in human natural killer cells.

1988 • 373 citations

Characterization of the lymphocyte activation gene 3-encoded protein. A new ligand for human leukocyte antigen class II antigens.

1992 • 366 citations

Monoclonal antibody to a triggering structure expressed on rat natural killer cells and adherent lymphokine-activated killer cells.

1989 • 365 citations

Human and mouse killer-cell inhibitory receptors recruit PTP1C and PTP1D protein tyrosine phosphatases.

1996 • 362 citations

Regulation of high-affinity IgE receptor-mediated mast cell activation by murine low-affinity IgG receptors.

1995 • 359 citations

CD4/major histocompatibility complex class II interaction analyzed with CD4‐ and lymphocyte activation gene‐3 (LAG‐3)‐Ig fusion proteins

1995 • 352 citations

Interferon gamma production by natural killer (NK) cells and NK1.1+ T cells upon NKR-P1 cross-linking.

1996 • 349 citations

Protein tyrosine phosphatase containing SH2 domains: characterization, preferential expression in hematopoietic cells, and localization to human chromosome 12p12-p13.

1992 • 349 citations

A human killer inhibitory receptor specific for HLA-A1,2.

1996 • 347 citations

Hematopoietic Cell Phosphatase Associates with the Interleukin-3 (IL-3) Receptor β Chain and Down-Regulates IL-3-Induced Tyrosine Phosphorylation and Mitogenesis

1993 • 340 citations

The human leukocyte antigen (HLA)-C-specific "activatory" or "inhibitory" natural killer cell receptors display highly homologous extracellular domains but differ in their transmembrane and intracytoplasmic portions.

1996 • 337 citations

Antigen-dependent clonal expansion of a trace population of antigen-specific CD4+ T cells in vivo is dependent on CD28 costimulation and inhibited by CTLA-4.

1995 • 323 citations

I-type Lectins

1995 • 318 citations

Superantigen-Dependent, Cell-Mediated Cytotoxicity Inhibited by MHC Class I Receptors on T Lymphocytes

1995 • 316 citations

Natural killer cell receptors

1995 • 314 citations

Molecular cloning of NKB1. A natural killer cell receptor for HLA-B allotypes.

1995 • 309 citations

Inhibitory MHC class I receptors on NK cells and T cells

1996 • 288 citations

Negative regulation of T-cell receptor signalling by tyrosine protein kinase p50csk

1993 • 283 citations

Altered T cell activation and development in transgenic mice expressing the HIV-1 nef gene.

1993 • 282 citations

Association of hematopoietic cell phosphatase with c-Kit after stimulation with c-Kit ligand.

1993 • 267 citations

Ontogeny of human natural killer (NK) cells: fetal NK cells mediate cytolytic function and express cytoplasmic CD3 epsilon,delta proteins.

1992 • 263 citations

Identification of the tyrosine phosphatase PTP1C as a B cell antigen receptor-associated protein involved in the regulation of B cell signaling.

1995 • 260 citations

A novel surface antigen expressed by a subset of human CD3- CD16+ natural killer cells. Role in cell activation and regulation of cytolytic function.

1990 • 254 citations

The enigma of the natural killer cell

1995 • 236 citations

The Role of Ly49A and 5E6(Ly49C) Molecules in Hybrid Resistance Mediated by Murine Natural Killer Cells Against Normal T Cell Blasts

1996 • 234 citations

ICAM-2 redistributed by ezrin as a target for killer cells

1996 • 233 citations

Levels of Peripheral T Cell Tolerance Induced by Different Doses of Tolerogen

1994 • 229 citations

Protein-tyrosine phosphatases.

1994 • 223 citations

Cytolytic T lymphocytes displaying natural killer (NK)-like activity: expression of NK-related functional receptors for HLA class I molecules (p58 and CD94) and inhibitory effect on the TCR-mediated target cell lysis or lymphokine production

1995 • 221 citations

Phosphotyrosines in the killer cell inhibitory receptor motif of NKB1 are required for negative signaling and for association with protein tyrosine phosphatase 1C.

1996 • 213 citations

Cloning and functional characteristics of murine large granular lymphocyte-1: a member of the Ly-49 gene family (Ly-49G2)

1995 • 212 citations

Tyrosine phosphorylation of a human killer inhibitory receptor recruits protein tyrosine phosphatase 1C.

1996 • 210 citations

Molecular characterization of human CD94: A type II membrane glycoprotein related to the C‐type lectin superfamily

1995 • 207 citations

Hematopoietic cell phosphatase associates with the interleukin-3 (IL-3) receptor beta chain and down-regulates IL-3-induced tyrosine phosphorylation and mitogenesis.

1993 • 204 citations

CD22 associates with protein tyrosine phosphatase 1C, Syk, and phospholipase C-gamma(1) upon B cell activation.

1996 • 200 citations

Human natural killer cell receptors for HLA-class I molecules. Evidence that the Kp43 (CD94) molecule functions as receptor for HLA-B alleles.

1994 • 193 citations

Allelic exclusion of Ly49-family genes encoding class I MHC-specific receptors on NK cells

1995 • 188 citations

CD94 and a Novel Associated Protein (94AP) Form a NK Cell Receptor Involved in the Recognition of HLA-A, HLA-B, and HLA-C Allotypes

1996 • 187 citations

Hematopoietic cell phosphatase associates with erythropoietin (Epo) receptor after Epo-induced receptor tyrosine phosphorylation: identification of potential binding sites

1995 • 187 citations

Abnormal T cell development in CD3-zeta-/- mutant mice and identification of a novel T cell population in the intestine.

1993 • 186 citations

CD22 associates with the human surface IgM-B-cell antigen receptor complex.

1993 • 185 citations

Signal transduction by Fc gamma RIII (CD16) is mediated through the gamma chain.

1992 • 184 citations

GRB2 and Phospholipase C-7γ1 Associate with a 36- to 38-Kilodalton Phosphotyrosine Protein after T-Cell Receptor Stimulation

1994 • 181 citations

Fc gamma receptor type III (CD16) is included in the zeta NK receptor complex expressed by human natural killer cells.

1990 • 169 citations

Natural killer cell receptors: The offs and ons of NK cell recognition

1995 • 163 citations

Independent Modes of Natural Killing Distinguished in Mice Lacking Lag3

1996 • 163 citations

Mouse mast cell gp49B1 contains two immunoreceptor tyrosine-based inhibition motifs and suppresses mast cell activation when coligated with the high-affinity Fc receptor for IgE.

1996 • 160 citations

A natural killer cell receptor specific for a major histocompatibility complex class I molecule.

1994 • 157 citations

Molecular cloning of the NK1.1 antigen, a member of the NKR-P1 family of natural killer cell activation molecules.

1992 • 155 citations

cDNA cloning of mouse NKR-P1 and genetic linkage with LY-49. Identification of a natural killer cell gene complex on mouse chromosome 6.

1991 • 153 citations

Endocytosis and Lysosomal Targeting of Epidermal Growth Factor Receptors Are Mediated by Distinct Sequences Independent of the Tyrosine Kinase Domain

1995 • 151 citations

Involvement of SH2-containing Phosphotyrosine Phosphatase Syp in Erythropoietin Receptor Signal Transduction Pathways

1995 • 147 citations

Differential functions of the two Src homology 2 domains in protein tyrosine phosphatase SH-PTP1.

1996 • 142 citations

A subunit common to an IgG Fc receptor and the T-cell receptor mediates assembly through different interactions.

1991 • 141 citations

Fc gamma receptor activation induces the tyrosine phosphorylation of both phospholipase C (PLC)-gamma 1 and PLC-gamma 2 in natural killer cells.

1992 • 138 citations

CD94 functions as a natural killer cell inhibitory receptor for different HLA class I alleles: identification of the inhibitory form of CD94 by the use of novel monoclonal antibodies

1996 • 133 citations

Tyrosine phosphorylation of the Fc gamma RIII(CD16): zeta complex in human natural killer cells. Induction by antibody-dependent cytotoxicity but not by natural killing.

1991 • 129 citations

NKR-P1A is a target-specific receptor that activates natural killer cell cytotoxicity.

1995 • 125 citations

NKR-P1, an activating molecule on rat natural killer cells, stimulates phosphoinositide turnover and a rise in intracellular calcium.

1991 • 124 citations

Functional ambivalence of the Kp43 (CD94) NK cell-associated surface antigen.

1995 • 124 citations

Association of the Interferon-dependent Tyrosine Kinase Tyk-2 with the Hematopoietic Cell Phosphatase

1995 • 121 citations

Mouse NKR-P1. A family of genes selectively coexpressed in adherent lymphokine-activated killer cells.

1991 • 121 citations

Phosphotyrosine‐dependent association between CD22 and protein tyrosine phosphatase 1C

1995 • 120 citations

Host MHC class I molecules modulate in vivo expression of a NK cell receptor.

1994 • 119 citations

Cross-linking of IgG receptors inhibits membrane immunoglobulin-stimulated calcium influx in B lymphocytes.

1993 • 117 citations

Cloning of the gp49B gene of the immunoglobulin superfamily and demonstration that one of its two products is an early-expressed mast cell surface protein originally described as gp49.

1994 • 114 citations

Physical and functional association of p56lck with Fc gamma RIIIA (CD16) in natural killer cells.

1993 • 113 citations

Natural T cells. Cells that co-express NKRP-1 and TCR.

1995 • 111 citations

Stimulation of Fc gamma RIIIA results in phospholipase C-gamma 1 tyrosine phosphorylation and p56lck activation.

1992 • 108 citations

GRB2 and phospholipase C-gamma 1 associate with a 36- to 38-kilodalton phosphotyrosine protein after T-cell receptor stimulation.

1994 • 103 citations

Tyrosine 425 within the activated erythropoietin receptor binds Syp, reduces the erythropoietin required for Syp tyrosine phosphorylation, and promotes mitogenesis

1996 • 100 citations

Phosphatidylinositol-3 kinase activation induced upon Fc gamma RIIIA-ligand interaction.

1994 • 99 citations

Transmembrane signalling through the T-cell-receptor-CD3 complex

1993 • 98 citations

Mutations in mice that influence natural killer (NK) cell activity

1981 • 95 citations

CD3-negative lymphokine-activated cytotoxic cells express the CD3 epsilon gene.

1988 • 94 citations

Tyrosine phosphorylation provides an early and requisite signal for the activation of natural killer cell cytotoxic function.

1991 • 93 citations

Inhibition of selective signaling events in natural killer cells recognizing major histocompatibility complex class I.

1995 • 84 citations

Rat natural killer cell antigen, NKR-P1, related to C-type animal lectins is a carbohydrate-binding protein

1994 • 84 citations

Involvement of p72syk kinase, p53/561yn kinase and phosphatidyl inositol‐3 kinase in signal transduction via the human B lymphocyte antigen CD22

1996 • 82 citations

The Staphylococcus aureus Enterotoxin B Superantigen Induces Specific T Cell Receptor Down-regulation by Increasing Its Internalization

1995 • 80 citations

Molecular cloning of gp49, a cell-surface antigen that is preferentially expressed by mouse mast cell progenitors and is a new member of the immunoglobulin superfamily

1991 • 79 citations

Structural similarity between Fc receptors and T cell receptors. Expression of the gamma-subunit of Fc epsilon RI in human T cells, natural killer cells and thymocytes.

1991 • 76 citations

Alternatively spliced forms of human killer inhibitory receptors

1996 • 73 citations

Genomic structure and strain-specific expression of the natural killer cell receptor NKR-P1.

1992 • 70 citations

Surface Molecules Involved in the Activation and Regulation of T or Natural Killer Lymphocytes in Humans

1989 • 67 citations

Phenotypic and Functional Effects of the Motheaten Gene on Murine B and T Lymphocytes

1979 • 63 citations

Biochemical and serologic evidence for the existence of functionally distinct forms of the CD94 NK cell receptor.

1996 • 59 citations

Block of T lymphocyte differentiation by activation of the cAMP-dependent signal transduction pathway.

1996 • 58 citations

Pleiotropic Effects of Deleterious Alleles at the “Motheaten” Locus

1988 • 57 citations

Down-regulation of CD8 on mature antigen-reactive T cells as a mechanism of peripheral tolerance.

1995 • 54 citations

CD16-mediated p21ras activation is associated with Shc and p36 tyrosine phosphorylation and their binding with Grb2 in human natural killer cells.

1996 • 53 citations

Arresting G-protein coupled receptor activity

1993 • 53 citations

Direct Determination of the Sequence Recognition Requirements of the SH2 Domains of SH-PTP2

1995 • 48 citations

Down-regulation of Drosophila Egf-r mRNA levels following hyperactivated receptor signaling

1994 • 46 citations

The regulation of B- and T-lymphocyte activation by the transmembrane protein tyrosine phosphatase CD45

1994 • 41 citations

Receptors for HLA class I molecules in human NK cells

1995 • 32 citations

Normal development and function of natural killer cells in CD3 epsilon delta 5/delta 5 mutant mice.

1995 • 30 citations

The natural killer-related receptor for HLA-C expressed on T cells from CD3+ lymphoproliferative disease of granular lymphocytes displays either inhibitory or stimulatory function

1996 • 30 citations

Hematopoiesis and models of immunodeficiency.

1991 • 28 citations

Intracellular Signalling: Switching off signals

1995 • 20 citations

Cross-linking of CD45 on NK cells stimulates p56lck-mediated tyrosine phosphorylation and IFN-gamma production.

1995 • 19 citations

Thymic Involution in Viable Motheaten (me^υ) Mice is Associated with a Loss of Intrathymic Precursor Activity

1992 • 11 citations

Evidence for a Glycoprotein IIb-IIIa- and Aggregation-independent Mechanism of Phosphatidylinositol 3′,4′-Bisphosphate Synthesis in Human Platelets

1995 • 10 citations

Inate immunity: Turning off natural killers

1996 • 6 citations

CD3 down‐regulating factor in sera and culture supernatants of leukaemic cells from patients with adult T cell leukaemia

1993 • 6 citations

Sensitization of T‐cell receptor‐αβ⁺ T cells recovered from long‐term T‐cell receptor downmodulation

1996 • 3 citations