The multifaceted circulating endothelial cell in cancer: towards marker and target identification

Isolation of Putative Progenitor Endothelial Cells for Angiogenesis

1997 • 8,673 citations

VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche

2005 • 3,066 citations

Molecular regulation of vessel maturation

2003 • 2,446 citations

Expression of VEGFR-2 and AC133 by circulating human CD34+ cells identifies a population of functional endothelial precursors

2000 • 2,286 citations

Endothelial Cells in Physiology and in the Pathophysiology of Vascular Disorders

1998 • 2,263 citations

Circulating Endothelial Progenitor Cells and Cardiovascular Outcomes

2005 • 2,023 citations

Impaired recruitment of bone-marrow–derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth

2001 • 1,874 citations

Therapeutic angiogenesis for patients with limb ischaemia by autologous transplantation of bone-marrow cells: a pilot study and a randomised controlled trial

2002 • 1,724 citations

Evidence for Circulating Bone Marrow-Derived Endothelial Cells

1998 • 1,666 citations

Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions

2001 • 1,640 citations

Activity of SU11248, a Multitargeted Inhibitor of Vascular Endothelial Growth Factor Receptor and Platelet-Derived Growth Factor Receptor, in Patients With Metastatic Renal Cell Carcinoma

2005 • 1,630 citations

Tumor Response to Radiotherapy Regulated by Endothelial Cell Apoptosis

2003 • 1,538 citations

Origins of circulating endothelial cells and endothelial outgrowth from blood

2000 • 1,529 citations

Clinical translation of angiogenesis inhibitors

2002 • 1,518 citations

The anti-angiogenic basis of metronomic chemotherapy

2004 • 1,363 citations

Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells

2003 • 1,303 citations

Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors

2005 • 1,266 citations

VEGF-Induced Adult Neovascularization: Recruitment, Retention, and Role of Accessory Cells

2006 • 1,122 citations

Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction

2004 • 1,111 citations

Lessons from phase III clinical trials on anti-VEGF therapy for cancer

2006 • 1,044 citations

Intracoronary Bone Marrow Cell Transfer After Myocardial Infarction

2006 • 1,002 citations

Disrupting tumour blood vessels

2005 • 909 citations

Clinical Application of Antiangiogenic Therapy: Microvessel Density, What It Does and Doesn't Tell Us

2002 • 794 citations

Vascular and haematopoietic stem cells: novel targets for anti-angiogenesis therapy?

2002 • 685 citations

Antivascular endothelial growth factor receptor (fetal liver kinase 1) monoclonal antibody inhibits tumor angiogenesis and growth of several mouse and human tumors.

1999 • 660 citations

Circulating Activated Endothelial Cells in Sickle Cell Anemia

1997 • 653 citations

Dynamic Contrast-Enhanced Magnetic Resonance Imaging As a Biomarker for the Pharmacological Response of PTK787/ZK 222584, an Inhibitor of the Vascular Endothelial Growth Factor Receptor Tyrosine Kinases, in Patients With Advanced Colorectal Cancer and Liver Metastases: Results From Two Phase I Studies

2003 • 651 citations

Cytokine-mediated deployment of SDF-1 induces revascularization through recruitment of CXCR4+ hemangiocytes

2006 • 639 citations

Therapy-Induced Acute Recruitment of Circulating Endothelial Progenitor Cells to Tumors

2006 • 572 citations

Vessel wall–derived endothelial cells rapidly proliferate because they contain a complete hierarchy of endothelial progenitor cells

2004 • 571 citations

Targeting exogenous genes to tumor angiogenesis by transplantation of genetically modified hematopoietic stem cells

2003 • 557 citations

Low-dose oral methotrexate and cyclophosphamide in metastatic breast cancer: antitumor activity and correlation with vascular endothelial growth factor levels

2002 • 494 citations

Contribution of bone marrow–derived endothelial cells to human tumor vasculature

2005 • 490 citations

Vascular wall resident progenitor cells: a source for postnatal vasculogenesis

2006 • 468 citations

Antiangiogenic Therapy: A Universal Chemosensitization Strategy for Cancer?

2006 • 467 citations

Maximum tolerable dose and low-dose metronomic chemotherapy have opposite effects on the mobilization and viability of circulating endothelial progenitor cells.

2003 • 458 citations

Tumor-Associated Endothelial Cells with Cytogenetic Abnormalities

2004 • 455 citations

Inhibition of tumor angiogenesis as a strategy to circumvent acquired resistance to anti‐cancer therapeutic agents

1991 • 441 citations

Apoptotic bodies from endothelial cells enhance the number and initiate the differentiation of human endothelial progenitor cells in vitro

2004 • 432 citations

Tumor-infiltrating dendritic cell precursors recruited by a β-defensin contribute to vasculogenesis under the influence of Vegf-A

2004 • 430 citations

Resting and activated endothelial cells are increased in the peripheral blood of cancer patients

2001 • 426 citations

Platelets secrete stromal cell–derived factor 1α and recruit bone marrow–derived progenitor cells to arterial thrombi in vivo

2006 • 415 citations

Adult bone marrow-derived cells recruited during angiogenesis comprise precursors for periendothelial vascular mural cells

2004 • 395 citations

Circulating endothelial cells

2005 • 381 citations

Evidence from a leukaemia model for maintenance of vascular endothelium by bone-marrow-derived endothelial cells

2000 • 346 citations

Genetic heterogeneity of the vasculogenic phenotype parallels angiogenesis

2005 • 331 citations

Lymphoma-Specific Genetic Aberrations in Microvascular Endothelial Cells in B-Cell Lymphomas

2004 • 317 citations

Genetically tagging endothelial cells in vivo: bone marrow-derived cells do not contribute to tumor endothelium

2004 • 284 citations

Transplanted adult hematopoietic stems cells differentiate into functional endothelial cells

2003 • 271 citations

Identification of the hemangioblast in postnatal life

2002 • 266 citations

Tumor angiogenesis and accessibility: Role of vascular endothelial growth factor

2002 • 262 citations

Optimal biologic dose of metronomic chemotherapy regimens is associated with maximum antiangiogenic activity

2005 • 256 citations

Circulating endothelial-cell kinetics and viability predict survival in breast cancer patients receiving metronomic chemotherapy

2006 • 253 citations

Endothelial cell apoptosis in systemic lupus erythematosus: a common pathway for abnormal vascular function and thrombosis propensity

2004 • 250 citations

Effect of angiogenesis inhibition by Id loss and the contribution of bone-marrow-derived endothelial cells in spontaneous murine tumors

2003 • 245 citations

Tumor angiogenesis and accessibility: Role of vascular endothelial growth factor

2002 • 239 citations

Chemokines direct endothelial progenitors into tumor neovessels

2005 • 238 citations

A homing mechanism for bone marrow-derived progenitor cell recruitment to the neovasculature

2006 • 222 citations

Circulating Endothelial Cells, Endothelial Progenitor Cells, and Endothelial Microparticles in Cancer

2006 • 213 citations

Circulating endothelial cells and angiogenic serum factors during neoadjuvant chemotherapy of primary breast cancer

2006 • 207 citations

Circulating endothelial cells in vascular disorders: new insights into an old concept

2000 • 202 citations

Circulating endothelial progenitor cells in multiple myeloma: implications and significance

2004 • 200 citations

Isolation and enumeration of circulating endothelial cells by immunomagnetic isolation: proposal of a definition and a consensus protocol

2006 • 192 citations

Metronomic low-dose oral cyclophosphamide and methotrexate plus or minus thalidomide in metastatic breast cancer: antitumor activity and biological effects

2005 • 183 citations

Magnetic Resonance Imaging and Confocal Microscopy Studies of Magnetically Labeled Endothelial Progenitor Cells Trafficking to Sites of Tumor Angiogenesis

2005 • 168 citations

Kinetics and viability of circulating endothelial cells as surrogate angiogenesis marker in an animal model of human lymphoma.

2001 • 163 citations

Differential Effects of Vascular Endothelial Growth Factor Receptor-2 Inhibitor ZD6474 on Circulating Endothelial Progenitors and Mature Circulating Endothelial Cells: Implications for Use as a Surrogate Marker of Antiangiogenic Activity

2005 • 160 citations

Evidence for incorporation of bone marrow–derived endothelial cells into perfused blood vessels in tumors

2005 • 145 citations

Differential CD146 Expression on Circulating Versus Tissue Endothelial Cells in Rectal Cancer Patients: Implications for Circulating Endothelial and Progenitor Cells As Biomarkers for Antiangiogenic Therapy

2006 • 131 citations

Inhibition of tumor growth by systemic treatment with thrombospondin‐1 peptide mimetics

2002 • 130 citations

Therapeutic Efficacy of Endostatin Exhibits a Biphasic Dose-Response Curve

2005 • 125 citations

Continuous infusion of endostatin inhibits differentiation, mobilization, and clonogenic potential of endothelial cell progenitors.

2003 • 124 citations

CD146 (Mel-CAM), an adhesion marker of endothelial cells, is a novel marker of lymphocyte subset activation in normal peripheral blood

2005 • 119 citations

A mathematical model of the contribution of endothelial progenitor cells to angiogenesis in tumors: implications for antiangiogenic therapy

2003 • 118 citations

Phase I Clinical Evaluation of Weekly Administration of the Novel Vascular-Targeting Agent, ZD6126, in Patients With Solid Tumors

2006 • 117 citations

Endostatin inhibits the vascular endothelial growth factor-induced mobilization of endothelial progenitor cells.

2003 • 113 citations

Neoplastic circulating endothelial cells in multiple myeloma with 13q14 deletion

2005 • 111 citations

CD144 (VE-cadherin) is transiently expressed by fetal liver hematopoietic stem cells

2005 • 107 citations

Circulating endothelial cells isolated together with platelets and the experimental modification of their counts in rats

1973 • 98 citations

Rapamycin inhibits proliferation and differentiation of human endothelial progenitor cells in vitro

2004 • 96 citations

Identification and functional assessment of endothelial P1H12

2001 • 93 citations

Bone marrow-derived, endothelial progenitor-like cells as angiogenesis-selective gene-targeting vectors

2003 • 89 citations

Assessing Tumor Angiogenesis

2004 • 84 citations

Phase 1 Study of ABT-751, a Novel Microtubule Inhibitor, in Patients with Refractory Hematologic Malignancies

2005 • 78 citations

Analysis of tumor‐associated stromal cells using SCID GFP transgenic mice: contribution of local and bone marrow‐derived host cells

2006 • 69 citations

Levels of circulating endothelial cells (CECs) and monocytes as pharmacodynamic markers of SU11248 activity in patients (pts) with metastatic imatinib-resistant GIST

2005 • 16 citations

Binding of vascular anticoagulant alpha (annexin V) to the aortic intima of the hypercholesterolemic rabbit. An autoradiographic study

1994 • 13 citations

Accrual Delayed in Adjuvant Bevacizumab Trial

2006 • 2 citations