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Primer3 on the WWW for General Users and for Biologist Programmers

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Integrin αvβ3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels

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Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor

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2000 • 1,430 citations

Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

1992 • 1,146 citations

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Isolation of a Protein Target of the FKBP12-Rapamycin Complex in Mammalian Cells

1995 • 859 citations

N-Methylated Cyclic RGD Peptides as Highly Active and Selective α_Vβ₃Integrin Antagonists

1999 • 803 citations

Rapamune® (RAPA, rapamycin, sirolimus): mechanism of action immunosuppressive effect results from blockade of signal transduction and inhibition of cell cycle progression

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Distinct mechanisms of suppression of murine T cell activation by the related macrolides FK-506 and rapamycin.

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Resting and activated endothelial cells are increased in the peripheral blood of cancer patients

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VEGFR-3 and CD133 identify a population of CD34+ lymphatic/vascular endothelial precursor cells

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2002 • 304 citations

Platelet-derived Growth Factor Receptor β and Vascular Endothelial Growth Factor Receptor 2 Bind to the β3Integrin through Its Extracellular Domain

2000 • 289 citations

Distinct signal transduction pathways are utilized during the tube formation and survival phases of in vitro angiogenesis

1998 • 266 citations

Identification of the hemangioblast in postnatal life

2002 • 266 citations

Novel Vascular Endothelial Growth Factor Binding Domains of Fibronectin Enhance Vascular Endothelial Growth Factor Biological Activity

2002 • 241 citations

Rapamycin is an effective inhibitor of human renal cancer metastasis11See Editorial by Sukhatme and Strom, p. 1160.

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v 3 and αvβ5 integrin antagonists inhibit angiogenesis in vitro

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αv‐Integrin antagonist EMD 121974 induces apoptosis in brain tumor cells growing on vitronectin and tenascin

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Integrin-mediated Signaling Events in Human Endothelial Cells

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Alphavbeta3 integrin antagonist S247 decreases colon cancer metastasis and angiogenesis and improves survival in mice.

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Rapamycin specifically interferes with GM-CSF signaling in human dendritic cells, leading to apoptosis via increased p27KIP1 expression

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Identification of the Adult Human Hemangioblast

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Cilengitide (EMD 121974) arrests the growth of a heavily pretreated highly vascularised head and neck tumour

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Integrin cytoplasmic domains as connectors to the cell's signal transduction apparatus

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Pretreatment vascular endothelial growth factor (VEGF) and matrix metalloproteinase-9 (MMP-9) serum levels in patients with metastatic non-small cell lung cancer (NSCLC)

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The predictive value of angiogenesis for adjuvant therapy in Breast Cancer

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