Glutathione deficiency in human disease

Glutathione metabolism and its selective modification.

1988 • 1,975 citations

Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine).

1979 • 1,680 citations

Selective Modification of Glutathione Metabolism

1983 • 1,272 citations

Regulation of cellular glutathione

1989 • 851 citations

SYSTEMIC GLUTATHIONE DEFICIENCY IN SYMPTOM-FREE HIV-SEROPOSITIVE INDIVIDUALS

1989 • 725 citations

Origin and turnover of mitochondrial glutathione.

1985 • 492 citations

Glutathione Deficiency in the Epithelial Lining Fluid of the Lower Respiratory Tract in Idiopathic Pulmonary Fibrosis

1989 • 472 citations

Status of the mitochondrial pool of glutathione in the isolated hepatocyte.

1982 • 440 citations

Glutathione deficiency leads to mitochondrial damage in brain.

1991 • 428 citations

Glutathione deficiency and human immunodeficiency virus infection

1992 • 409 citations

Cytokine-stimulated human immunodeficiency virus replication is inhibited by N-acetyl-L-cysteine.

1990 • 381 citations

Role of membrane transport in metabolism and function of glutathione in mammals

1986 • 376 citations

High-affinity transport of glutathione is part of a multicomponent system essential for mitochondrial function.

1990 • 283 citations

Glutathione is required for intestinal function.

1990 • 279 citations

Glutathione contents of tissues in the aging mouse

1980 • 268 citations

The systemic availability of oral glutathione

1992 • 263 citations

Inhibition of HIV-1 replication and NF-x B activity by cysteine and cysteine derivatives

1991 • 256 citations

Hepatic Glutathione Homeostasis in the Rat: Efflux Accounts for Glutathione Turnover

1984 • 256 citations

Deficiency of Alveolar Fluid Glutathione in Patients with Sepsis and the Adult Respiratory Distress Syndrome

1991 • 252 citations

Dynamic state of glutathione in blood plasma.

1980 • 249 citations

Impaired uptake of glutathione by hepatic mitochondria from chronic ethanol-fed rats. Tracer kinetic studies in vitro and in vivo and susceptibility to oxidant stress.

1991 • 247 citations

Glutathione and its function in the lens—An overview

1990 • 246 citations

Effect of N-acetylcysteine on plasma cysteine and glutathione following paracetamol administration

1989 • 234 citations

Promotion of cystine uptake and its utilization for glutathione biosynthesis induced by cysteamine and N-acetylcysteine

1988 • 234 citations

Hepatic mitochondrial glutathione depletion and progression of experimental alcoholic liver disease in rats

1992 • 228 citations

Mitochondrial damage in muscle occurs after marked depletion of glutathione and is prevented by giving glutathione monoester.

1989 • 206 citations

Low blood glutathione levels in healthy aging adults.

1992 • 206 citations

Plasma cysteine, cystine, and glutathione in cirrhosis

1984 • 183 citations

Cysteine and glutathione concentrations in plasma and bronchoalveolar lavage fluid after treatment with N-acetylcysteine.

1991 • 179 citations

Radioprotection by glutathione ester: transport of glutathione ester into human lymphoid cells and fibroblasts.

1984 • 179 citations

Exogenous glutathione protects intestinal epithelial cells from oxidative injury.

1986 • 173 citations

Direct evidence for inter-organ transport of glutathione and that the non-filtration renal mechanism for glutathione utilization involves γ-glutamyl transpeptidase

1980 • 164 citations

The role of glutathione in lymphocyte activation. I. Comparison of inhibitory effects of buthionine sulfoximine and 2-cyclohexene-1-one by nuclear size transformation.

1985 • 153 citations

Glutathione metabolism in the lung: inhibition of its synthesis leads to lamellar body and mitochondrial defects.

1989 • 153 citations

Glutathione Synthetase Deficiency, an Inborn Error of Metabolism Involving the γ-Glutamyl Cycle in Patients with 5-Oxoprolinuria (Pyroglutamic Aciduria)

1974 • 150 citations

γ-Glutamyl-Cysteine Synthetase Deficiency

1972 • 149 citations

Glutathione depletion in HIV-infected patients: role of cysteine deficiency and effect of oral N-acetylcysteine.

1992 • 148 citations

Protection against paraquat-induced injury by exogenous GSH in pulmonary alveolar type II cells

1986 • 146 citations

Cystine uptake and glutathione level in endothelial cells exposed to oxidative stress

1992 • 142 citations

Hepatic thiol and glutathione efflux under the influence of vasopressin, phenylephrine and adrenaline

1985 • 136 citations

Excretion of cysteine and gamma-glutamylcysteine moieties in human and experimental animal gamma-glutamyl transpeptidase deficiency.

1980 • 127 citations

Familial deficiency of glutathione reductase in human blood cells

1976 • 122 citations

Influence of mouse age and erythrocyte age on glutathione metabolism

1978 • 115 citations

Oral glutathione increases tissue glutathione in vivo

1991 • 107 citations

Augmentation of glutathione in the fluid lining the epithelium of the lower respiratory tract by directly administering glutathione aerosol.

1990 • 104 citations

Hormonal regulation of glutathione efflux.

1990 • 103 citations

Glutathione Synthetase Deficiency as a Cause of Hereditary Hemolytic Disease

1970 • 97 citations

Plasma concentrations of transsulfuration pathway products during nasoenteral and intravenous hyperalimentation of malnourished patients

1985 • 94 citations

Transport of cystine in isolated rat hepatocytes in primary culture.

1984 • 92 citations

Bioavailability of dietary glutathione: effect on plasma concentration

1990 • 88 citations

Glutathione monoethyl ester can selectively protect liver from high dose BCNU or cyclophosphamide

1988 • 84 citations

Glutathione deficiency increases organ dysfunction after hemorrhagic shock.

1992 • 82 citations

The role of glutathione in aging and cancer

1992 • 80 citations

Reversible Cardiomyopathy Due to Selenium Deficiency

1989 • 79 citations

L-2-oxothiazolidine-4-carboxylic acid, a cysteine prodrug: pharmacokinetics and effects on thiols in plasma and lymphocytes in human.

1991 • 74 citations

Increase in endothelial cell glutathione and precursor amino acid uptake by diethyl maleate and hyperoxia

1989 • 68 citations

Marked increase of cysteine levels in many regions of the brain after administration of 2‐oxothiazolidine‐4‐carboxylate

1989 • 65 citations

Elevation of Glutathione Levels in Bovine Pulmonary Artery Endothelial Cells by N-Acetylcysteine

1992 • 58 citations

Glutathione peroxidase and selenium deficiency in patients receiving home parenteral nutrition: time course for development of deficiency and repletion of enzyme activity in plasma and blood cells

1989 • 54 citations

Effect of hyperoxia on glutathione levels and glutamic acid uptake in endothelial cells

1987 • 53 citations

Effects of Low Protein Diets or Feed Restriction on Rat Lung Glutathione and Oxygen Toxicity

1985 • 52 citations

Effect of Dietary Protein Deficiency and L-2-Oxothiazolidine-4-Carboxylate on the Diurnal Rhythm of Hepatic Glutathione in the Rat

1988 • 46 citations

Hereditary high concentration of glutathione in canine erythrocytes associated with high accumulation of glutamate, glutamine, and aspartate

1982 • 45 citations

Reduction of Glutathione Is Associated with Growth Restriction and Enlargement of Bovine Pulmonary Artery Endothelial Cells Produced by Transforming Growth Factor-β₁

1992 • 44 citations

Induction of cystine transport activity in isolated rat hepatocytes by sulfobromophthalein and other electrophilic agents

1986 • 43 citations

Gamma-glutamylcysteine synthetase deficiency and hemolytic anemia

1990 • 43 citations

Elevated plasma glutamate concentrations in HIV-1-infected patients may contribute to loss of macrophage and lymphocyte functions

1989 • 41 citations

The effect of cysteine and N-acetyl cysteine on rat liver glutathione (GSH)

1983 • 40 citations

Glucose-6-phosphate dehydrogenase: new perspectives [see comments]

1989 • 37 citations

The Activity of Glutathione-S-Transferases in Various Organs of the Rat

1980 • 36 citations

Divergent effects of intravenous GSH and cysteine on renal and hepatic GSH

1992 • 35 citations

Prevention of sulfhydryl autoxidation by a polypeptide from red kidney beans, described to be a stimulator of RNA synthesis

1977 • 31 citations

Glutathione enhancement in various mouse organs and protection by glutathione isopropyl ester against liver injury

1990 • 28 citations

Intestinal glutathione transport system: a possible detoxication role

1991 • 25 citations

Parenteral Glutathione Monoester Enhances Tissue Antioxidant Stores

1992 • 21 citations

Availability of cysteine and of L‐2‐oxo‐thiazolidine‐4‐carboxylic acid as a source of cysteine in intravenous nutrition

1990 • 21 citations

Utilization of methionine and n-acetyl-l-cysteine during long-term parenteral nutrition in the growing rat

1986 • 19 citations

Potentiation of Acute Acetaminophen Lethality by Selenium and Vitamin E Deficiency in Mice

1992 • 16 citations

DIAGNOSIS AND TREATMENT OF POISONING

1957 • 12 citations