Calpain II activity and calpastatin content in brain regions of 3- and 24-month-old rats

A simplification of the protein assay method of Lowry et al. which is more generally applicable

1977 • 8,485 citations

Intracellular Ca2+-dependent protease (CALPAIN) and its high-molecular-weight endogenous inhibitor (CALPASTATIN)

1981 • 374 citations

Calpain and calpastatin

1983 • 304 citations

Brain fodrin: substrate for calpain I, an endogenous calcium-activated protease.

1984 • 294 citations

Dephosphorylation of neurofilament proteins enhances their susceptibility to degradation by calpain

1988 • 232 citations

Treatment Development Strategies for Alzheimer’s Disease

1987 • 198 citations

Micromolar Calcium Stimulates Proteolysis and Glutamate Binding in Rat Brain Synaptic Membranes

1981 • 180 citations

Characterization of a brain calcium-activated protease that degrades neurofilament proteins

1982 • 160 citations

Bulk Preparation of CNS Cytoskeleton and the Separation of Individual Neurofilament Proteins by Gel Filtration: Dye‐Binding Characteristics and Amino Acid Compositions

1982 • 154 citations

Regulation of activity of calcium activated neutral protease

1988 • 116 citations

Purification and characterization of two forms of Ca2+-activated neutral protease from calf brain.

1983 • 110 citations

Effect of Age on Brain Cortical Protein Kinase C and Its Mediation of 5‐Hydroxytryptamine Release

1989 • 93 citations

Distribution of calpain I, an enzyme associated with degenerative activity, in rat brain

1985 • 92 citations

Calcium-activated neutral protease (CANP) in brain and other tissues

1984 • 91 citations

Treatment development strategies for Alzheimer's disease

1986 • 84 citations

Calcium Regulation in Biological Systems

1985 • 82 citations

Activation of a calmodulin-dependent phosphatase by a calcium-dependent protease

1988 • 82 citations

Identification and partial purification of a factor that stimulates calcium-dependent proteases

1982 • 81 citations

EFFECTS OF AGEING ON LOCAL RATES OF CEREBRAL PROTEIN SYNTHESIS IN SPRAGUE-DAWLEY RATS

1985 • 81 citations

Transport systems for amphipathic compounds in normal and neoplastic hepatocytes

1988 • 74 citations

Calcium-mediated breakdown of glial filaments and neurofilaments in rat optic nerve and spinal cord

1981 • 72 citations

Multiple calcium-activated neutral proteinases (CANP) in mouse retinal ganglion cell neurons: specificities for endogenous neuronal substrates and comparison to purified brain CANP

1986 • 60 citations

Increase in cathepsin D activity in rat brain in aging

1989 • 58 citations

Regional distribution of soluble calcium activated proteinase activity in neonatal and adult rat brain

1985 • 57 citations

An endogenous activator of the Ca2+-dependent proteinase of human neutrophils that increases its affinity for Ca2+.

1988 • 57 citations

Age-dependent changes in brain protein synthesis in the rat

1980 • 53 citations

Calcium-Activated Neutral Proteinase of Human Brain: Subunit Structure and Enzymatic Properties of Multiple Molecular Forms

1986 • 49 citations

Limited proteolytic modification of a neurofilament protein involves a proteinase activated by endogenous levels of calcium

1983 • 46 citations

Age-related changes in protein synthesis

1983 • 44 citations

Differential effects of age on the pathways of calcium influx into nerve terminals

1987 • 41 citations

Metabolic studies in vitro of the CNS cytoskeletal proteins: Synthesis and degradation

1984 • 35 citations

Purified glial fibrillary acidic protein and desmin are distinct intermediate filament proteins exhibiting similar properties.

1981 • 32 citations

Developmental changes of calpain and calpastatin in rabbit brain

1989 • 29 citations

Protein synthesis rates in rat brain regions and subcellular fractions during aging

1988 • 26 citations

Isovalerylcarnitine is a specific activator of calpain of human neutrophils

1987 • 23 citations

Fractionation and quantification of calcium-dependent proteinase activity from small tissue samples

1986 • 20 citations

The presence of ATP + ubiquitin-dependent proteinase and multicatalytic proteinase complex in bovine brain

1989 • 15 citations

The pH dependence of breakdown of various purified brain proteins by cathepsin D preparations

1985 • 15 citations

Regional distribution of brain calpastatin and of calpain II. Activity with casein and with endogenous brain protein substrates

1989 • 14 citations

The role of calpain in the selective increased phosphorylation of the anion-transport protein in red cell of hypertensive subjects

1988 • 13 citations

A Simple Procedure for the Isolation of Brain Actin

1981 • 9 citations